Indoda ezimiseleyo evela eIndiya ilwa nomhlaza wesisu

Kukho indoda enesibindi egama linguThirandas Shiva Prasad. Ineminyaka engama-32 ubudala, kwaye ivela eIndiya. Kutheni sigxininisa ukuzimisela kwayo? Nasi ibali layo elimangalisayo.

UThirandas wafunyaniswa enomhlaza wesisu ngo-2023, ebonakala enentlungu esiswini kwaye waqinisekiswa njenge-adenocarcinoma yeseli ye-signet ring ekumgangatho ophantsi. Wenziwa i-chemotherapy ye-neoadjuvant nge-FLOT regimen, elandelwa lutyando oluquka i-subtotal gastrectomy. Nangona unyango lwasemva kotyando, umhlaza waphinda wavela kunye ne-metastases kwi-pelvis, nto leyo eyabangela iingxaki ezifana ne-hydronephrosis, amathumba, kunye nokuthintelwa. Wanyamezela ukungenelela okuninzi, kuquka i-dialysis, i-stenting, kunye ne-chemo eyongezelelweyo nge-nab-paclitaxel, i-nivolumab, i-irinotecan, kunye nezinye. Ngo-2025, ii-PET-CT scans zabonisa ukuqhubela phambili kunye nokwanda kwezilonda zesisu kunye ne-ascites, nto leyo eyamshiya efuna iindlela ezintsha.

Efuna unyango olusemgangathweni, uThirandas waphendukela kwi-BIOOCUS. Iqela lethu leengcali linike uvavanyo lokuqala lwasimahla, liphonononga imbali yakhe ebanzi kwaye licebisa unyango lweeseli ze-CLDN18.2 CAR-T, olulungiselelwe ukubonakala kwethumba lakhe. Emva kokulungiswa kwangaphambili, utyando lwenziwa kakuhle kwiziko lethu eliphambili. Nangona imingeni yokuqala efana nomkhuhlane kunye nosulelo olunokubakho, iqela lethu lezifundo ezahlukeneyo lalawula iimpawu ngokufanelekileyo ngamayeza okubulala iintsholongwane kunye nonyango oluxhasayo, ukuqinisekisa ukuba akukho CRS inzima. Iinkqubo ezifana nokuphuma kwamanzi esiswini kunye nokulungiswa kwe-stent ziphathwe ngokuchanekileyo, nto leyo ekhokelele ekunciphiseni iimpawu kunye neziphumo ezilungileyo zesifo emva konyango.

I-BIOOCUS ibalasele ngenkonzo yayo egqwesileyo kunye neemveliso ezintsha. Unyango lwethu lwe-CAR-T, olujolise kwi-CLDN18.2, lubonelela ngohlaselo olujoliswe kwiiseli zomhlaza, luhlala luphumelela apho unyango oluqhelekileyo lungaphumeleli khona. Iinkonzo zesigulana zigqwesile ekuququzeleleni uhambo lwamazwe ngamazwe, ukubonelela ngolwazelelelo lwenkcubeko, kunye nokubonelela ngolandelelwano olupheleleyo, konke ngaphandle komthwalo owongezelelweyo. I-Thirandas iyabaxabisa abasebenzi abanovelwano kunye neenkqubo ezisebenzayo eziguqule amava anzima abe lithemba.