Umfana oselula okwaziyo ukunyamezela ovela eRashiya ulwa ne-neuroblastoma

Kukho umloli omncinci onzima ogama linguKuvatov Emin. Uneminyaka esi-8 ubudala, kwaye uvela eRashiya. Kutheni siyithanda indlela anyamezela ngayo? Nasi ibali lakhe elinamandla.

U-Emin wafunyaniswa ene-neuroblastoma kwiminyaka emihlanu eyadlulayo, ebekwe kwinqanaba le-IV ene-bone marrow metastasis kunye ne-MYCN gain. Wenziwa i-induction chemotherapy enzulu, utyando, ukufakelwa kweeseli ze-stem ze-autologous, kunye nonyango lokwahlulahlula, efumana ukuxolelwa kokuqala. Nangona kunjalo, ukuphinda-phinda kwenzeke, kubandakanya amathambo kunye nama-lymph nodes, nangona iindlela zodidi lwesibini ezifana ne-bevacizumab, irinotecan, temozolomide, kwanokufakelwa kwe-allogeneic. Ngo-2025, ii-MIBG scans zabonisa ukuqhubela phambili kwezilonda ezintsha, nto leyo eyabangela ukuba usapho lwakhe luhlolisise iindlela zehlabathi.

Kwi-BIOOCUS, ityala lika-Emin lahlolwa simahla ziingcali zethu, ezathi zafumanisa i-GD2 CAR-T njengonyango oluthembisayo lokusindisa. Emva kokulungiswa kwangaphambili nge-fludarabine kunye ne-cyclophosphamide, iiseli ze-CAR-T zafakwa ngaphandle kweengxaki. Ukwanda kwaqina, kwaye amaxabiso apheleleyo anyuka kakhulu ngomhla wesi-7. Ukubeka esweni okucokisekileyo kweqela lethu kuthintele iziganeko ezimbi, kwaye i-pathology yaqinisekisa impembelelo yonyango kwithumba lakhe elalingahlukanga kakuhle.

Iingenelo ze-BIOOCUS zikwindlela yethu esemgangathweni, egxile kwizigulane kunye neemveliso ze-CAR-T ezibalaseleyo. Sinikezela ngamayeza achanekileyo kwindawo enika inkxaso, kunye neenkonzo eziquka ukulungelelaniswa kwamazwe ngamazwe okungenamthungo, iingcebiso zosapho, kunye nokulandelela emva konyango. Abazali baka-Emin bayayincoma inyameko yobubele eyanciphisa iinkxalabo zabo ngeli xesha linzima.