Impendulo Ephawulekayo kwi-Refractory Multiple Myeloma Emva koNyango lweeSeli zeCAR-T

Iprofayili yesigulanaUMnu. Mohamed H., indoda eneminyaka engama-70 ubudala evela eJiphutha

Ukuxilongwa kokuqalaI-myeloma enininzi edibene nomzimba. I-PET/CT yangaphambi konyango (Julayi 2024) ibonise izilonda zamathambo ezininzi ezingasebenzi kakuhle kulo lonke ulusu lwe-axial kunye ne-appendicular, kunye nezilonda ezininzi ezitshabalalisayo kunye ne-SUV ephezulu ye-17.9, nto leyo ebonisa ukuba isifo sisebenza kakhulu.

UnyangoEmva kokuqhubela phambili kwi-chemotherapy eqhelekileyo, uMnu. Mohamed wafuna iindlela eziphambili waza wakhetha i-Bioocus kwi-immunotherapy yeeseli ze-CAR-T ekujoliswe kuzo.

Iziphumo Zokulandelela (ngoSeptemba 2024 – ziinyanga ezi-2 kuphela emva konyango)I-PET/CT ephindaphindwayo yomzimba wonke ibonakalisiwe:

• Ukuncipha okukhulu komsebenzi we-metabolic phantse kuzo zonke izilonda ebezisebenza ngaphambili
• Izilonda ezininzi ziphelile ngokupheleleyo (akukho ukuthathwa kwe-FDG okungaqhelekanga)
• I-SUV ephezulu yehle ukusuka kwi-17.9 ukuya kwi-5.16
• Kusele kuphela ukufunxwa komongo okuncinci, okuhambelana notshintsho oluvela emva konyango.
• Akukho foci intsha ye-hypermetabolic kwithambo okanye kwizicubu ezithambileyo

UMnu. Mohamed akazange abonakalise iimpawu emva nje kokufakwa inaliti. Uthi amandla akhe abuyele esiqhelweni, akukho ntlungu emathanjeni, kwaye ubuyele kubomi bakhe bemihla ngemihla obuqhelekileyo - iziphumo azichaza njenge "thuba lesibini."

“Ngaphambi kokuba intlungu ibe kuyo yonke indawo, kwaye bendicinga ukuba esi sisiphelo. Emva konyango lwe-CAR-T eBioocus, ndiziva njengomntu omtsha. Iskeni yamva nje ibonisa ukuba umhlaza sele uphelile. Ndinombulelo kakhulu.” — Mnu. Mohamed H.

Eli tyala libonisa amandla anamandla onyango lwe-CAR-T ekufezekiseni iimpendulo ezikhawulezayo nezinzulu, kwanakwizigulane ezindala ezine-multiple myeloma esele iphucukile, esele inyangwe kakhulu.