Imfazwe kaWu: Ukubandezeleka yi-multiple myeloma

Isigulana uWu, indoda eneminyaka engama-71 ubudala, ufunyaniswe ene-multiple myeloma.

Ufune unyango kwiBioocus International Medical Center ngo-2022 kwaye wonelisekile kakhulu yinkathalo yakhe. I-pathology yokuqala yatyhila iziphumo ze-lumbar MRI kunye ne-T5T scan, kuquka ukwaphuka kwe-T10, T11, kunye ne-L1 cone kunye ne-bone marrow edema. Ukongeza, imiqondiso emincinci engaqhelekanga yabonwa emzimbeni we-L2 vertebral. I-vertebral puncture biopsy yaqinisekisa i-plasma cell myeloma. Uvavanyo olongezelelweyo lubonise i-prokaryotic plasma equka i-46% ye-bone marrow biopsy, kunye neeseli ezingaqhelekanga ezifakwe kwi-14% kwi-flow cytometry. I-bone junction biopsy yabonisa i-70% problastoma. Uhlalutyo lwe-FISH lwatyhila ukulahleka kwe-gene kwi-lq21 (CKSIB) kunye ne-1m32 (CDKN2C), ngelixa uvavanyo lwe-FTSH lwalubonisa ukususwa kwe-gene ye-p53, kwaye i-ICH yayine-negative kuvavanyo lwe-FISH. Ukuxilongwa kokugqibela yayiyi-multiple osteoblastic follipoma (uhlobo lwe-L light chain), kunye ne-DS staging kwiqela le-B, i-ISS staging III, kunye ne-RISS staging kwiSigaba sesi-2. Isigulana uWu sivakalise umbulelo ngonyango olupheleleyo nolwenzelwe wena olubonelelwe yiziko lezonyango.

Imbali yonyango yangaphambili:

Iimpawu zeklinikhi ze-multiple myeloma zahlukile, ikakhulu kubandakanya i-anemia, iintlungu zamathambo, ukungasebenzi kakuhle kwezintso, usulelo, ukopha, iimpawu zemithambo-luvo, i-hypercalcemia, kunye ne-amyloid stool. Isibhedlele senze unyango olunamandla lokulwa nosulelo kwaye salungisa i-anemia kunye neeplatelets ezisezantsi. Malunga neenyanga ezi-2 emva kokufakwa kwe-BCMA CAR-T cell, izalathisi zesigulana zabuyela kwisiqhelo kancinci kancinci, kwaye imeko yaso yayilawulwa. I-Bioocus International Medical Center ibisoloko ijonga isigulana ukuqinisekisa uzinzo oluqhubekayo lweziphumo zonyango.