Hondo yaWu: Kutambura nemultiple myeloma

Murwere Wu, murume ane makore makumi manomwe nerimwe ekuberekwa, akaonekwa aine chirwere chemultiple myeloma.

Akatsvaga kurapwa kuBioocus International Medical Center muna 2022 uye akagutsikana zvikuru nerubatsiro rwake. Pathology yekutanga yakaratidza kuwanikwa kweMRI yemuchiuno neT5T scan, kusanganisira T10, T11, uye L1 cone breakages ne bone marrow edema. Pamusoro pezvo, zviratidzo zvidiki zvisina kujairika zvakaonekwa mumuviri weL2 vertebral. Biopsy ye vertebral puncture yakaratidza plasma cell myeloma. Ongororo dzakatevera dzakaratidza prokaryotic plasma ine 46% ye bone marrow biopsy, nemasero asina kujairika akasungirirwa ari 14% mu flow cytometry. Bone junction biopsy yakaratidza 70% problastoma. Kuongorora kweFISH kwakaratidza kurasikirwa kwemajini mu lq21 (CKSIB) ne 1m32 (CDKN2C), nepo FTSH test yaive yakanaka ye p53 gene deletion, uye ICH yaive negative muFISH test. Kuongororwa kwekupedzisira kwaive multiple osteoblastic follipoma (L light chain type), neDS staging muchikamu B group, ISS staging III, uye RISS staging muchikamu II. Murwere Wu akaratidza kutenda nekurapwa kwakazara uye kwakagadzirirwa munhu kwakapihwa nechipatara.

Nhoroondo yekurapwa kwakamboitwa:

Zviratidzo zve multiple myeloma zvakasiyana-siyana, zvinosanganisira kupererwa neropa, kurwadziwa kwemapfupa, kusashanda zvakanaka kweitsvo, hutachiona, kubuda ropa, zviratidzo zvetsinga, hypercalcemia, uye tsvina yeamyloid. Chipatara chakarapa zvakasimba hutachiona uye chakagadzirisa kupererwa neropa uye maplatelet akaderera. Mwedzi miviri mushure mekuiswa kweBCMA CAR-T cell, zviratidzo zvemurwere zvakadzokera kune zvakajairika zvishoma nezvishoma, uye mamiriro ake akanga adzorwa. Bioocus International Medical Center yagara ichitarisa murwere kuti ive nechokwadi chekuti mhedzisiro yekurapa yagara iripo.