Bjørn Simensen----Multiple Myeloma (IgG lambda) ISS-II

Makorokoto! Murwere wekuNorway, Bjørn Simensen, ane makore maviri ekuzorora kwenguva refu.

Murume ane makore makumi matanhatu nemanomwe ekuberekwa Bjørn Simensen akauya kuchipatara munaGunyana 2017 achinyunyuta nezvekukosora nekurwadziwa pachipfuva. Paaiongororwa, akawanikwa aine multiple myeloma (IgG lambda) ISS-II. Murwere akapihwa bortezomib, lenalidomide uye dexamethasone chemotherapy ka4. Mushure memwedzi mina, protein yake yeM yaive pasi pe1g/l. Murwere akabva abuda muchipatara chelenalidomide (10mg qdx3 weeks pamwedzi m) chaakaramba achiita kwemakore maviri akatevera. Akaramba asina chirwere kusvika muzhizha ra2021 apo panguva yekuongorora akawanikwa aine M protein yakawedzera (5g/l). Lenalidomide akamiswa uye akatanga kurapwa carfilzomib uye daratumumab chemotherapy kubva muna Gumiguru kusvika Zvita 2021. Zvisinei, chemotherapy haina kushanda uye post-chemo BM MRD yakanga yakanaka.

VaBjørn Simensen vakaonekwa kekutanga panzvimbo yedu yeCGT musi wa14 Kukadzi 2022. BM MRD yavo yakaratidza 0.25 muzana yemasero eplasma asina kujairika. IEF yakaratidza kuti IgG neprotein yeM yaive 3 g/l. PET-CT Scan yakaratidza kuwedzera kwekutora mutestis kunyanya kurudyi iyo yakazowedzerwawo pakuongororwa. Biopsy yematesticular yakaitwa yakaratidza masero eplasma ane malignant. Murwere akasarudzwa kuti apihwe CART cell therapy. Kugadziriswa kwakaitwa ne fludarabine ne cyclophosphamide kwemazuva matatu. CAR-T Cells dzakaiswa pazuva re0 (4/3/2222). Dose yakapihwa yaive 0.5X10^6 /kg. Mushure mekuisirwa, murwere aive neutropenia fever iyo yakadzorwa nemishonga inorwisa mabhakitiriya. Kuzvimba kwematesticular ekurudyi kwakadzikira zvishoma nezvishoma kusvika pahukuru hwakajairika. Pazuva rechi28 kuongororwa kweBM kwaive kusina masero eplasma. Murwere akaburitswa kuLu Daopei nekuongororwa nguva dzose munzvimbo yeropa muguta rake.