Kukunda Diffuse Large B-Cell Lymphoma neBioocus Dual CAR-T Therapy

Nhoroondo yeMurwere

Rodney, munhu ane simba kubva kunze kwenyika, akaonekwa aine chirwere cheDiffuse Large B-Cell Lymphoma (DLBCL), rudzi rwakasimba rwe non-Hodgkin lymphoma. Ava nemakore makumi matanhatu nemasere ekuberekwa, akatsvaga nzira dzekurapa dzepamusoro mushure mekunge kurapwa kwakajairika kwaratidza kusakwana. Paakatumirwa kuchipatara cheTianjin Cancer Hospital, Rodney akanyoresa muBioocus's dual CAR-T therapy protocol pasi penhamba yekurapa P1549. Kurapa uku kunonangana nemaantigen eCD19 neCD20 pamasero ekenza, zvichipa kurwisa kwakasimba kuti kuwedzere kushanda zvakanaka uye kuderedza njodzi yekudzokera kuchirwere.

Rwendo rweKurapwa

Kurapwa kwaRodney kwakatanga munaGunyana 2025 nekushandiswa kwemasero eCAR-T akagadzirwa kuti abudise chimeric antigen receptors yeCD19 neCD20. Maitiro acho aisanganisira kutora sample yake yeropa (PB), kuigadzira kuti igadzire masero eCAR-T akagadzirirwa iye, uye kuisa dose yaaida. Mushure mekuiswa mushonga, kufambira mberi kwake kwakanyatsotariswa kuburikidza nekuongororwa kweropa mumazuva akakosha ekutevera: Zuva rechina (D4), Zuva rechi7 (D7), uye Zuva rechigumi (D10).

• D4 (Gunyana 12, 2025):Kuonekwa kwekutanga kwakaratidza kuvapo kwemaseru eCAR-T zvishoma, nemasero eCD19+ CAR-T ari pa0.50% yemasero eCD3+ T (kukosha kwakakwana: 6.04 × 10^6/L) uye masero eCD20+ CAR-T ari pa0.41% (kukosha kwakakwana: 4.96 × 10^6/L). Danho rekutanga iri rakaratidza kubudirira kwekuiswa kwemasero aya.
• D7 (Gunyana 15, 2025):Kukura kwakakurumidza, masero eCD19+ CAR-T achikwira kusvika pa1.68% (kukosha kwakakwana: 1.40 × 10^7/L) uye masero eCD20+ CAR-T kusvika pa1.63% (kukosha kwakakwana: 1.36 × 10^7/L), zvichiratidza kuwanda kwakasimba.
• D10 (Gunyana 18, 2025):Kukura kukuru kwakaonekwa, nemasero eCD19+ CAR-T achisvika 31.43% emasero eCD3+ T (kukosha kwakakwana: 3.13 × 10^8/L) uye masero eCD20+ CAR-T pa32.74% (kukosha kwakakwana: 3.26 × 10^8/L). Kuongororwa kwezvikamu zvakati wandei kwakaratidza kupararira kwakaringana pakati pemasero eCD4+ neCD8+ T, nehuwandu hwemasero eT pa2.9 × 10^9/L, kusanganisira masero eCD3+ T 34.35%.

Mukati mekuongorora, chimiro chemuviri waRodney chekudzivirira chirwere chakaratidza shanduko dzakanaka, dzakadai sekuwedzera kwemasero eT ane chepfu (CD3+CD8+ pa69.56%), zvichiratidza kugona kwekurapa uku kusimudzira masoja ake ekudzivirira chirwere ichi kurwisa lymphoma.

Migumisiro Yakanaka

Pakazosvika D10, kukura kwakanyanya mumasero eCAR-T—kuwedzera kwe500 muzana yehuwandu hwemasero kubva kuD4—kwakaratidza kushanda kwakasimba kwekurapa uku kurwisa bundu. Kuwedzera uku nekukurumidza chiratidzo chekubudirira kwekurapa kweCAR-T, kazhinji kunoenderana nekurerutswa kwakadzama uye kwenguva refu muvarwere veDLBCL. Rodney akatsungirira kurapwa zvakanaka, pasina matambudziko makuru akataurwa muchikamu chekutarisa. Nyaya yake inoratidza nzira yeBioocus yeCAR-T mbiri, iyo yakawana mhinduro yakakwana (CR) uye huwandu hwemhinduro (ORR) muboka redu revarwere pasi rose.