Ho Hlōla Lymphoma e Kholo ea Lisele tsa B tse Fapaneng ka Kalafo ea Bioocus Dual CAR-T

Semelo sa Mokuli

Rodney, motho ea nang le mamello ea tsoang linaheng tse ling, o ile a fumanoa a e-na le Diffuse Large B-Cell Lymphoma (DLBCL), mofuta o matla oa non-Hodgkin lymphoma. Ha a le lilemo li 68, o ile a batla mekhoa e tsoetseng pele ea phekolo ka mor'a hore mekhoa ea phekolo e tloaelehileng e se ke ea lekana. Ha a romeloa setsing sa rona sa balekane Sepetleleng sa Kankere sa Tianjin, Rodney o ile a ingolisa ho Bioocus's dual CAR-T therapy protocol tlas'a nomoro ea kalafo P1549. Kalafo ena e shebane le li-antigen tsa CD19 le CD20 liseleng tsa kankere, e fana ka tlhaselo e nang le mahlakore a mabeli ho ntlafatsa katleho le ho fokotsa kotsi ea ho khutlela morao.

Leeto la Kalafo

Kalafo ea Rodney e qalile ka Loetse 2025 ka ho kenngoa ha lisele tsa CAR-T tsa autologous tse entsoeng ho hlahisa li-receptor tsa chimeric antigen bakeng sa CD19 le CD20. Ts'ebetso ena e ne e kenyelletsa ho bokella sampole ea hae ea mali a kantle (PB), ho e sebetsana ho etsa lisele tsa CAR-T tse ikhethileng, le ho kenya tekanyo e etselitsoeng litlhoko tsa hae. Kamora ho kenngoa, tsoelo-pele ea hae e ile ea beoa leihlo haufi-ufi ka liteko tsa mali tse latellanang matsatsing a bohlokoa a ho latela: Letsatsi la 4 (D4), Letsatsi la 7 (D7), le Letsatsi la 10 (D10).

• D4 (La 12 Loetse, 2025):Ho lemoha qalong ho bontshitse boteng bo itekanetseng ba disele tsa CAR-T, ka disele tsa CD19+ CAR-T ho 0.50% ya disele tsa CD3+ T (boleng bo feletseng: 6.04 × 10^6/L) le disele tsa CD20+ CAR-T ho 0.41% (boleng bo feletseng: 4.96 × 10^6/L). Mokgahlelo ona wa pele o bontshitse ho kenngwa ha disele ka katleho.
• D7 (La 15 Loetse, 2025):Katoloso e potlakile, ka disele tsa CD19+ CAR-T tse nyolohelang ho 1.68% (boleng bo felletseng: 1.40 × 10^7/L) le disele tsa CD20+ CAR-T ho 1.63% (boleng bo felletseng: 1.36 × 10^7/L), tse bontshang keketseho e matla.
• D10 (La 18 Loetse, 2025):Katoloso e tsotehang e bonoe, ka lisele tsa CD19+ CAR-T tse fihlang ho 31.43% ea lisele tsa CD3+ T (boleng bo felletseng: 3.13 × 10^8/L) le lisele tsa CD20+ CAR-T ho 32.74% (boleng bo felletseng: 3.26 × 10^8/L). Tlhahlobo ea subset e senotse kabo e leka-lekaneng ho pholletsa le lisele tsa CD4+ le CD8+ T, ka palo ea lisele tsa T ka kakaretso ho 2.9 × 10^9/L, ho kenyeletsoa le lisele tsa CD3+ T tse 34.35%.

Nakong eohle ea tlhokomelo, boemo ba 'mele oa Rodney ba ho itšireletsa mafung bo bontšitse liphetoho tse ntle, tse kang lisele tse phahameng tsa T tse nang le chefo (CD3+CD8+ ho 69.56%), e leng se totobatsang bokhoni ba phekolo ea ho hlohlelletsa sesole sa hae sa 'mele khahlanong le lymphoma.

Liphetho tse Ikhethang

Ho fihlela ka D10, kgolo e phatlohang ya disele tsa CAR-T—e leng keketseho e fetang makgetlo a 500 ya dipalo tse feletseng ho tloha ho D4—e ile ya totobatsa tshebetso e matla ya kalafo ya ho lwantsha hlahala. Katoloso ena e potlakileng ke letshwao la kalafo e atlehileng ya CAR-T, hangata e amanang le phokotso e tebileng le e tshwarellang ho bakudi ba DLBCL. Rodney o ile a mamella kalafo hantle, ntle le mathata a maholo a tlalehilweng mohatong wa tlhokomelo. Nyeoe ya hae e bontsha mohlala wa mokgwa wa Bioocus wa CAR-T o nang le di-double, o fihletseng karabelo e phahameng e felletseng (CR) le sekgahla sa karabelo ka kakaretso (ORR) ho pholletsa le sehlopha sa rona sa bakudi ba lefatshe.