Kev Kov Yeej Diffuse Large B-Cell Lymphoma nrog Bioocus Dual CAR-T Therapy

Keeb Kwm ntawm Tus Neeg Mob

Rodney, ib tug neeg uas muaj zog los ntawm txawv teb chaws, tau kuaj pom tias muaj Diffuse Large B-Cell Lymphoma (DLBCL), uas yog ib hom mob non-Hodgkin lymphoma uas ua rau mob hnyav heev. Thaum muaj hnub nyoog 68 xyoo, nws tau nrhiav kev kho mob siab dua tom qab kev kho mob ib txwm tsis txaus. Thaum nws raug xa mus rau peb lub chaw kho mob ntawm Tianjin Cancer Hospital, Rodney tau koom nrog Bioocus's dual CAR-T therapy protocol raws li tus lej kho mob P1549. Kev kho mob no tsom mus rau ob qho tib si CD19 thiab CD20 antigens ntawm cov hlwb qog noj ntshav, muab kev tawm tsam ob qho tib si los txhim kho kev ua haujlwm thiab txo qhov kev pheej hmoo ntawm kev rov qab los.

Txoj Kev Kho Mob

Kev kho mob ntawm Rodney tau pib thaum lub Cuaj Hli 2025 nrog kev txhaj tshuaj ntawm cov qe ntshav CAR-T uas tau tsim los qhia txog cov cim xeeb chimeric antigen receptors rau CD19 thiab CD20. Cov txheej txheem no suav nrog kev sau nws cov ntshav peripheral (PB) qauv, ua nws los tsim cov qe ntshav CAR-T uas haum rau nws tus kheej, thiab txhaj tshuaj raws li nws xav tau. Tom qab txhaj tshuaj, nws txoj kev vam meej tau raug saib xyuas ze los ntawm kev kuaj ntshav ntau zaus rau hnub tseem ceeb: Hnub 4 (D4), Hnub 7 (D7), thiab Hnub 10 (D10).

• D4 (Cuaj Hlis 12, 2025):Thaum xub thawj pom tias muaj cov hlwb CAR-T me me xwb, nrog rau cov hlwb CD19+ CAR-T ntawm 0.50% ntawm cov hlwb CD3+ T (tus nqi tag nrho: 6.04 × 10^6/L) thiab cov hlwb CD20+ CAR-T ntawm 0.41% (tus nqi tag nrho: 4.96 × 10^6/L). Lub sijhawm thaum ntxov no qhia tau tias tau cog rau hauv cov hlwb zoo.
• D7 (Cuaj Hlis 15, 2025):Kev nthuav dav tau nrawm dua, nrog rau CD19+ CAR-T hlwb nce mus txog 1.68% (tus nqi tag nrho: 1.40 × 10^7/L) thiab CD20+ CAR-T hlwb mus txog 1.63% (tus nqi tag nrho: 1.36 × 10^7/L), qhia tau tias muaj kev loj hlob sai.
• D10 (Cuaj Hlis 18, 2025):Tau pom tias muaj kev nthuav dav siab tshaj plaws, nrog rau CD19+ CAR-T hlwb ncav cuag 31.43% ntawm CD3+ T hlwb (tus nqi tag nrho: 3.13 × 10^8/L) thiab CD20+ CAR-T hlwb ntawm 32.74% (tus nqi tag nrho: 3.26 × 10^8/L). Kev tshuaj xyuas subset qhia tau tias muaj kev faib tawm sib npaug thoob plaws CD4+ thiab CD8+ T hlwb, nrog rau tag nrho cov suav T-cell ntawm 2.9 × 10^9/L, suav nrog 34.35% CD3+ T hlwb.

Thoob plaws hauv kev soj ntsuam, Rodney tus qauv tiv thaiv kab mob tau qhia txog kev hloov pauv zoo, xws li cov qe ntshav dawb cytotoxic T siab (CD3 + CD8 + ntawm 69.56%), qhia txog kev kho mob lub peev xwm los txhawb nws lub cev tiv thaiv kab mob tawm tsam tus kab mob lymphoma.

Cov Txiaj Ntsig Zoo Tshaj Plaws

Los ntawm D10, qhov kev loj hlob sai heev hauv CAR-T hlwb - ntau dua 500 npaug ntawm cov lej los ntawm D4 - qhia txog kev kho mob lub zog tiv thaiv qog. Qhov kev nthuav dav sai no yog lub cim ntawm kev kho mob CAR-T ua tiav, feem ntau cuam tshuam nrog kev zam txim tob thiab ruaj khov hauv cov neeg mob DLBCL. Rodney zam kev kho mob zoo, tsis muaj teeb meem loj tau tshaj tawm hauv theem saib xyuas. Nws cov ntaub ntawv piv txwv txog Bioocus txoj hauv kev CAR-T ob chav, uas tau ua tiav cov lus teb tiav (CR) thiab cov nqi teb tag nrho (ORR) thoob plaws peb cov neeg mob thoob ntiaj teb.