Pawg Kev Kho Mob

Cov Kev Kho Mob Tshwj Xeeb

Kev Kho Mob Cancer: Kev Kho Mob Cancer Siab Tshaj Plaws

CAR-T rau Glioblastoma

Nusinersen Sodium Txhaj Tshuaj: Kev Cia Siab rau Kev Mob Pob Txha

Kev Kho Mob CAR-T Rau Mob Cancer Hauv Plab

$Kev Kho Mob CAR-T rau Kev Rov Qab Los/Refractory Neuroblastoma$

Kev Kho Mob CAR-T rau Kev Rov Qab Los/Refractory Neuroblastoma

CAR-T rau Systemic Lupus Erythematosus (SLE)

Kab mob Sickle Cell thiab Thalassemia

Kev Kho Mob Gene Tshiab Muab Kev Cia Siab Tshiab rau Cov Neeg Mob Sickle Cell thiab Thalassemia

FUCASO: Kev Kho Mob BCMA CAR-T Uas Hloov Pauv Tag Nrho Rau Tib Neeg Nrog Kev Ua Haujlwm Zoo Thiab Kev Nyab Xeeb Tsis Sib Xws

Siv NK Cells: Txhim Kho Kev Kho Mob Cancer Dhau Ntawm Cov Ciam Teb

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Kev Txheeb Xyuas Txog Kev Kho Mob Leukemia Tshiab

CAR-T Therapy, luv rau Chimeric Antigen Receptor T-Cell Immunotherapy, yog ib txoj kev kho mob gene siab heev uas cuam tshuam txog kev hloov kho tus neeg mob cov T cell kom tsom mus rau thiab rhuav tshem cov cell mob qog noj ntshav. Tsis zoo li cov tshuaj ib txwm muaj, CAR-T therapy yog tsim rau txhua tus neeg mob thiab yuav tsum tau sau cov T cell los ntawm tus neeg mob cov ntshav ua ntej rov muab lawv rov qab rau hauv lub cev tom qab kev kho genetic engineering.

Tiv tauj peb

Cov cim qhia ntawm CAR-T

● B-cell mob qog ntshav lymphoblastic mob hnyav

●ntau yam mob myeloma

●Kab mob leukemia lymphocytic ntev

●Cov kab mob lymphoma uas tsis yog Hodgkin

●Diffuse loj B-cell lymphoma

●Kab mob SLE (Systemic Lupus Erythematosus)

●Myasthenia gravis

●Lwm cov kab mob autoimmune

Kev ua haujlwm zoo heev ntawm CAR-T hauv kev kho mob

Cov cim qhia rau CD19 + 20CAR-T: Cov neeg mob uas muaj B-cell non Hodgkin's lymphoma

Tus nqi CR ib hlis	Tus nqi PR ib hlis	Tus nqi ib hlis LOS YOG	CRS≥3	CRES≥3
71.95% (59/82)	25.6 (21/82)	97.55 (80/82)	12.19% (10/82)	0

Cov cim qhia rau CD19 + 22CAR-T: Kev kho mob ntawm cov neeg mob CD19 uas rov qab mob dua thiab tsis kho tau kab mob B-lymphocytic leukemia

Tus nqi CR ib hlis	Tus nqi PR ib hlis	Tus nqi ib hlis LOS YOG	CRS≥3	CRES≥3
92.1% (35/38)	7.9% (3/38)	100% (38/38)	15.79% (6/38)	0

Cov cim qhia rau BCMACAR-T: Kev kho mob ntawm cov mob multiple myeloma uas rov tshwm sim thiab tsis kho tau

Tus nqi CR ib hlis	Tus nqi PR ib hlis	Tus nqi ib hlis LOS YOG	CRS≥3	CRES≥3
72.41% (21/29)	27.59% (8/29)	100% (29/29)	6.9% (2/29)	0

Kev Txheeb Xyuas Txog Kev Kho Mob CAR-T (2)tch

Peb Qhov Zoo

● Kev Kho Mob Tus KheejTxhua txoj kev kho mob CAR-T yog kho kom haum rau tus neeg mob, kom ntseeg tau tias muaj txiaj ntsig zoo thiab muaj txiaj ntsig zoo.

● Kev Xaiv Ntau Hom PhiajNrog ntau yam antigens, suav nrog CD7, CD19, CD20, CD22, thiab BCMA, peb cov khoom CAR-T muaj kev hloov pauv zoo tshaj plaws hauv kev kho ntau yam kab mob hematological thiab cov kab mob autoimmune.

● Kev vam meej hauv kev kho mob uas tau lees paubPeb cov kev kho mob CAR-T tau ua pov thawj tias muaj txiaj ntsig zoo heev rau ntau qhov teeb meem kev kho mob, nrog rau cov nqi zam txim zoo kawg thiab cov ntaub ntawv kev nyab xeeb, ua rau peb txoj haujlwm ua tus thawj coj hauv kev kho mob tiv thaiv kab mob.

● Kev Siv Nyiaj ZooPeb muab kev sib tw zoo dua nrog kev kho mob zoo tshaj plaws ntawm tus nqi pheej yig dua piv rau lwm cov khoom CAR-T hauv khw.

● Kev Siv Tshuab TshiabSiv cov kev nce qib tshiab kawg hauv kev tsim kho caj ces, peb cov kev kho mob CAR-T suav nrog yav tom ntej ntawm kev kho mob qog noj ntshav thiab kab mob autoimmune.

● Kev Txhawb Nqa Hauv Chaw Kho Mob Los Ntawm Kws Tshaj LijPeb pab neeg kws kho mob thiab cov kws tshawb fawb uas muaj kev paub dhau los muab kev saib xyuas zoo txij li thaum pib sab laj mus txog rau kev tswj hwm kev kho mob thiab kev saib xyuas tom qab.

Cov qe ntshav CAR-T tam sim no tau lees paub dav dav rau lawv cov txiaj ntsig zoo rau cov neeg mob uas tsis tau teb rau cov kev kho mob ib txwm muaj xws li chemotherapy lossis hloov pob txha. Lub zej zog kho mob thoob ntiaj teb lees paub lub peev xwm tshiab ntawm CAR-T kev kho mob hauv kev hloov pauv cov txiaj ntsig ntawm tus neeg mob.

Cov kev tshawb fawb thiab cov rooj plaub ntsig txog kev kho mob CAR-T

1. Kev Kho Mob CAR-T rau Systemic Lupus Erythematosus: Kev Ua Haujlwm Zoo Kawg Nkaus Hauv Cov Menyuam Yaus

Ib qho teeb meem tseem ceeb ntawm Erlangen University Hospital tau qhia txog kev ua haujlwm ntawm CAR-T cell therapy hauv kev kho tus ntxhais hnub nyoog 15 xyoo uas muaj mob systemic lupus erythematosus (SLE). Tom qab ntau yam kev kho mob tsis ua tiav, Uresa tau txais kev kho mob tshiab no thaum Lub Rau Hli 2023. Peb lub lis piam tom qab kev kho mob, nws cov tsos mob tau zoo dua qub, ua rau nws rov zoo thiab rov qab ua haujlwm ntawm lub raum. Qhov kev vam meej no yog thawj zaug siv CAR-T therapy rau cov kab mob autoimmune hauv menyuam yaus, qhia txog nws lub peev xwm los ua kom rov zoo mus sij hawm ntev thiab hloov pauv cov txiaj ntsig ntawm tus neeg mob. Kev tshawb fawb ntxiv tab tom ua los tshawb nrhiav nws cov ntawv thov hauv cov xwm txheej zoo sib xws.

https://www.bioocus.com/news/breakthrough-in-pediatric-autoimmune-disease-car-t-cell-therapy-cures-lupus-patient/

2. Kev Kho Mob CAR-T rau Multiple Myeloma: Kev Zam Txim Zoo Tau Tiav Lawm

Bjørn Simensen, ib tug neeg mob hnub nyoog 67 xyoo los ntawm Norway, tau muaj kev hloov pauv zoo kawg nkaus hauv nws txoj kev sib ntaus sib tua tiv thaiv ntau yam myeloma (IgG lambda, ISS-II) tom qab tau txais kev kho mob CAR-T cell. Thaum xub thawj nws tau kuaj pom tias muaj mob hauv xyoo 2017, nws tau txais ntau yam kev kho mob chemotherapy, tab sis rov qab mob dua hauv xyoo 2021. Tom qab kev kho mob tsis zoo, nws tau raug xa mus rau Tsev Kho Mob Lu Daopei thaum Lub Ob Hlis 2022, qhov chaw uas nws tau raug xaiv los kho mob CAR-T. Tom qab kev kho mob ua ntej, nws cov CAR-T cell tau raug txhaj rau hauv. Thaum txog hnub 28, kev kuaj mob tom qab tsis pom muaj cov plasma cell txawv txav hauv nws cov pob txha, uas yog ib qho kev ua tiav tseem ceeb hauv nws txoj kev kho mob.

https://www.bioocus.com/bj-rn-simensen-multiple-myeloma-igg-lambda-iss-ii-product/

3. CD7 CAR-T Kev Kho Mob rau Cov T-ALL thiab LBL Rov Qab Los: Kev Ua Haujlwm Zoo thiab Cov Txiaj Ntsig Zoo

Cov kev tshawb fawb tsis ntev los no qhia txog kev ua haujlwm ntawm CD7 chimeric antigen receptor T-cell (CAR-T) kev kho mob ua ke nrog kev hloov pauv hlwb allogeneic hematopoietic stem cell thib ob (HSCT) rau cov neeg mob uas rov qab mob T-cell acute lymphoblastic leukemia (T-ALL) thiab lymphoblastic lymphoma (LBL). Kev tshawb fawb no tau ua nyob rau hauv Hebei Yanda Lu Daopei Tsev Kho Mob, uas muaj 16 tus neeg mob uas tau txais kev zam txim tag nrho 100% tom qab kev kho mob. Nrog rau 75% kev zam txim tag nrho rau cov qhov txhab extramedullary thiab ib xyoos tag nrho kev ciaj sia thiab cov nqi ciaj sia tsis muaj leukemia ntawm 58.5% thiab 51.4%, raws li, txoj hauv kev tshiab no muab kev cia siab tshiab rau kev zam txim mus sij hawm ntev hauv cov mob qog nqaij hlav no.

https://www.bioocus.com/news/promising-outcomes-of-cd7-car-t-therapy-combined-with-second-transplant-in-relapsed-t-all-lbl-patien/

4. Kev Kho Mob CAR-T rau B-Cell Acute Lymphoblastic Leukemia: Kev Ua Haujlwm Zoo Tshaj Plaws

Tsis ntev los no, kev tshawb fawb tau qhia txog qhov ua tau zoo ntawm kev kho mob chimeric antigen receptor-T cell (CAR-T) hauv kev kho mob B-cell acute lymphoblastic leukemia (B-ALL). Kev tshawb fawb tau ua ke nrog BIOOCUS thiab Lu Daopei Tsev Kho Mob, qhia tau tias muaj ntau tus neeg mob tau zoo tag nrho, thiab lawv tau muab CAR-T therapy ua ib txoj kev kho mob tseem ceeb rau tus kab mob leukemia no. Cov txiaj ntsig zoo no qhia txog kev hloov pauv ntawm CAR-T therapy hauv oncology, ua rau cov neeg mob thiab tsev neeg uas ntsib B-ALL muaj kev cia siab. Thaum kev tshawb fawb mus ntxiv, CAR-T therapy yuav ua lub luag haujlwm tseem ceeb rau yav tom ntej ntawm kev kho mob qog noj ntshav.

https://www.bioocus.com/news/pioneering-car-t-therapy-in-b-cell-acute-lymphoblastic-leukemia-shows-unprecedented-efficacy/

Cov Txheej Txheem Kho Mob CAR-T

1. Kev Sau Cov T-Cell:

Thaum xub thawj, cov kws kho mob yuav sau cov qe ntshav T los ntawm cov ntshav ntawm tus neeg mob siv txoj kev kho mob hu ua leukapheresis. Cov txheej txheem no feem ntau siv sijhawm li 4 teev, thaum lub sijhawm ntawd lub tshuab cais cov qe ntshav dawb uas xav tau thiab xa cov khoom seem rov qab rau tus neeg mob lub cev.

2. Kev Hloov Kho thiab Kev Nthuav Dav ntawm Genetic:

Cov T cell uas tau sau los lawm raug xa mus rau chav kuaj mob kom hloov kho caj ces. Hauv kauj ruam no, T cell raug tsim los tsom thiab rhuav tshem cov cell mob qog noj ntshav. Cov txheej txheem no siv sijhawm li 2-3 lub lis piam. Thaum lub sijhawm no, cov T cell raug qhib thiab nthuav dav hauv chav kuaj mob kom ntseeg tau tias lawv ua haujlwm tau zoo tiv thaiv mob qog noj ntshav.

3. Kev txhaj tshuaj rau hauv lub hlwb:

Tom qab cov qe ntshav T uas tau tsim kho tiav lawm, lawv yuav rov qab muab tso rau hauv tus neeg mob lub cev los ntawm kev txhaj tshuaj rau hauv cov hlab ntsha. Cov kauj ruam no tso cai rau cov qe ntshav tiv thaiv kab mob uas tau hloov kho kom paub thiab tshem tawm cov qe ntshav qog nqaij hlav tau zoo.

Cov neeg mob yuav muaj kev phiv tshuaj thaum lub sijhawm kho mob, qhov feem ntau yog cytokine release syndrome (CRS), uas yog los ntawm kev tiv thaiv kab mob thaum lub sijhawm ua rau cov qog nqaij hlav puas tsuaj. Txawm hais tias CRS tuaj yeem hnyav heev, kev nce qib hauv kev kho mob tau txo nws cov kev pheej hmoo.

Tag nrho lub voj voog kev kho mob, txij li kev sau cov cell mus rau kev txhaj tshuaj, feem ntau siv sijhawm 4-6 lub lis piam, txawm hais tias lub sijhawm tseeb yog nyob ntawm tus neeg mob tus mob tshwj xeeb.

Kev Txhawb Nqa Rau Cov Neeg Mob Thoob Ntiaj Teb Mus Rau BIOOCUS Rau Kev Kho Mob CAR-T

Ntawm BIOOCUS, peb mob siab rau kev muab kev saib xyuas zoo tshaj plaws thiab kev txhawb nqa rau cov neeg mob thoob ntiaj teb uas tab tom nrhiav kev kho mob CAR-T. Peb cov kev pabcuam dav dav npog txhua kauj ruam ntawm txoj kev taug kev, txij li kev npaj ua ntej mus ncig mus rau kev saib xyuas tom qab kev kho mob.

1. Kev Npaj Ua Ntej Mus Ncig Tebchaws

Ua ntej mus rau BIOOCUS, cov neeg mob yuav raug soj ntsuam ua ntej ntawm lawv lub chaw kho mob hauv zos. Qhov no suav nrog kev tshuaj xyuas keeb kwm kev kho mob, kev kuaj lub cev, thiab kev kuaj mob xws li kev ua haujlwm ntshav, kev tshawb fawb duab, thiab kev kuaj mob tshwj xeeb rau hom mob qog noj ntshav uas tau kho (xws li leukemia, lymphoma, lossis lwm yam mob qog ntshav). Peb xyuas kom meej tias txhua cov ntaub ntawv kho mob, suav nrog kev kho mob ua ntej, cov txiaj ntsig ntawm kev kuaj mob, thiab kev lees paub kev kuaj mob, raug xa mus rau peb pab neeg kom tshuaj xyuas thiab npaj.

2. Kev Mus Ncig Tebchaws thiab Kev Nyob Hauv Tsev Kho Mob

Peb pab txhua yam ntawm kev mus ncig, suav nrog kev npaj chaw nyob thiab kev tseg chaw pw hauv BIOOCUS International Medical Center. Thaum tuaj txog, cov neeg mob raug coj los ntawm cov txheej txheem nkag mus, kom ntseeg tau tias kev hloov pauv mus rau qhov chaw kho mob zoo.

3. Txheej Txheem Kho Mob

Thaum nkag mus rau hauv tsev kho mob, cov neeg mob yuav raug kuaj mob ua ntej ntau zaus, suav nrog kev ntsuam xyuas kom paub tseeb tias tsim nyog rau kev kho mob CAR-T. Qhov no yuav suav nrog kev tshuaj xyuas tus neeg mob tus mob qog noj ntshav thiab kev noj qab haus huv tag nrho, nrog rau kev sau ntshav rau kev rho tawm T-cell. Cov T-cells uas tau sau los tom qab ntawd raug xa mus rau peb lub chaw kuaj mob GMP rau kev hloov pauv caj ces. Cov txheej txheem no tuaj yeem siv sijhawm li 2-3 lub lis piam.

4. Kev Muab Cell Infusion Thiab Kev Saib Xyuas Tom Qab Kev Kho Mob

Thaum cov hlwb CAR-T uas tau hloov kho tiav lawm, cov neeg mob yuav rov qab mus rau peb lub tsev kho mob rau cov txheej txheem infusion. Qhov no yog kev kho mob ib zaug xwb uas cov hlwb T uas tau tsim kho tshiab raug muab tso rau hauv cov hlab ntsha. Tom qab infusion, cov neeg mob yuav nyob twj ywm saib xyuas ze li ob peb hnub kom saib xyuas cov kev mob tshwm sim, xws li cytokine release syndrome, uas yog qhov tshwm sim ntawm kev kho mob. Peb pab neeg kho mob muab kev txhawb nqa thiab kev saib xyuas tas mus li thaum lub sijhawm tseem ceeb no.

Tom qab tawm hauv tsev kho mob lawm, BIOOCUS yuav saib xyuas cov neeg mob tas li, suav nrog kev kuaj mob hauv chaw kuaj mob thiab kev tshawb nrhiav duab, los saib xyuas qhov kev kho mob zoo thiab taug qab tus neeg mob txoj kev zoo rov qab los. Cov neeg mob yuav raug saib xyuas ze rau txhua qhov teebmeem lig ntawm kev kho mob, thiab peb pab neeg yuav sib txuas lus kom muab kev taw qhia thiab kev txhawb nqa tas mus li.

Ntawm BIOOCUS, peb muab qhov tseem ceeb rau kev noj qab haus huv, kev nyab xeeb, thiab kev nplij siab ntawm peb cov neeg mob thoob ntiaj teb. Peb lub hom phiaj yog muab kev saib xyuas kom zoo thiab xyuas kom muaj kev txhawb nqa, kev paub tsis muaj teeb meem thoob plaws hauv kev kho mob CAR-T.

Yog xav paub ntxiv txog peb cov kev pabcuam thiab peb yuav pab tau koj li cas rau kev kho mob, thov hu rau peb ncaj qha.

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