Kev Kho Mob CAR-T Rau Mob Cancer Hauv Plab

Claudin18.2 (CLDN18.2) yog ib qho protein isoform uas sib txuas lus zoo heev uas qhia tawm hauv cov epithelium ntawm lub plab thiab muaj ntau dhau ntawm qhov chaw ntawm cov hlwb qog nqaij hlav hauv lub plab. CT041 (tus lej tsim kho CG4006) yog ib yam khoom CAR-T uas tsom mus rau CLDN18.2. Cov ntaub ntawv theem I qhia tau tias muaj kev ua haujlwm tiv thaiv qog nqaij hlav zoo rau cov neeg mob qog nqaij hlav hauv lub plab uas tau kho mob hnyav, CLDN18.2-zoo.

HER2 overexpression kuj pom muaj nyob rau hauv ib pawg neeg mob qog noj ntshav hauv plab. Kev kho mob CAR-T uas siv HER2 tau ua pov thawj tias muaj peev xwm tiv thaiv qog noj ntshav hauv kev tshawb fawb ua ntej thiab thaum ntxov. Triumvira Immunologics' TAC01-HER2 tam sim no nyob rau hauv theem II kev sim tshuaj.

• Kev Targeting Tshwj XeebLos ntawm kev coj cov hlwb CAR-T tawm tsam CLDN18.2 lossis HER2, cov hlwb mob qog noj ntshav hauv plab tuaj yeem txheeb xyuas thiab tshem tawm tau meej, txo cov teebmeem ntawm cov qog noj ntshav.

• Kev kov yeej Kev Tiv Thaiv Kev Kho Mob Ntau KabHauv kev sim CT041, cov neeg mob qog noj ntshav hauv plab tau txais tus nqi teb rov qab (ORR) ntawm 57.1%, tus nqi tswj kab mob (DCR) ntawm 75.0%, thiab 6-lub hlis tag nrho muaj sia nyob (OS) ntawm 81.2% rau cov neeg mob uas tsis tau ua tiav ntau txoj kev kho mob yav dhau los.

• Cov Lus Teb Uas Ruaj KhovKev kho mob CLDN18.2-CAR-T tau ua rau muaj kev teb sai rau 6 lub hlis ntawm 44.8%, qhia txog qhov muaj peev xwm rau kev pab kho mob mus sij hawm ntev.

• Kev Kho Mob Rau Tus KheejSiv cov qe ntshav T ntawm tus neeg mob txo qhov kev pheej hmoo ntawm kev tsis lees txais thiab ua kom muaj kev nyab xeeb thiab kev ua haujlwm zoo dua.

• Kev Sau Cov Ntshav T-Cell Peripheral
  Cov qe ntshav T raug rho tawm ntawm tus neeg mob cov ntshav ntawm sab nraud los ntawm kev siv leukapheresis.

• Kev Tsim Kho Genetic
  Hauv chav kuaj mob uas ua raws li GMP, cov T cell raug hloov mus rau qhov qhia tawm CAR uas tsom mus rau CLDN18.2 lossis HER2, tom qab ntawd nthuav dav ex vivo.

• Kev Kho Mob Lymphodepleting
  Ib qho kev npaj kho mob ntawm cyclophosphamide thiab fludarabine yog siv los ua kom cov lymphocytes endogenous ploj mus thiab tsim kom muaj qhov chaw zoo rau kev nthuav dav ntawm CAR-T cell.

• Kev txhaj tshuaj CAR-T Cell
  Cov hlwb CAR-T uas tau tsim kho dua tshiab raug txhaj rov qab rau hauv tus neeg mob cov hlab ntsha.

• Kev Saib Xyuas thiab Kev Tswj Xyuas
  Tom qab txhaj tshuaj rau hauv lub cev lawm, cov neeg mob raug saib xyuas ze rau qhov cytokine release syndrome (CRS) thiab neurotoxicity, nrog rau kev kho mob raws sijhawm yog tias xav tau.

• CT041 (CLDN18.2-CAR-T) Kev Tshuaj Xyuas Ib Nrab Theem I
  Ntawm 37 tus neeg mob uas tau kho mob hnyav, pawg mob qog noj ntshav hauv plab tau ua tiav ORR 57.1%, DCR 75.0%; 94.6% tsuas yog muaj Qib 1-2 CRS xwb, tsis muaj Qib 3 lossis siab dua CRS lossis neurotoxicity; 6-lub hlis ntev ntawm kev teb yog 44.8%.

• Satri-cel (tseem tsom mus rau CLDN18.2) Cov Txiaj Ntsig Zaum Kawg ntawm Theem I
  Hauv 98 tus neeg mob qog noj ntshav hauv plab uas muaj CLDN18.2-zoo, ORR yog 38.8%, DCR 91.8%; lub neej nruab nrab tsis muaj mob hnyav (mPFS) yog 4.4 lub hlis (95% CI 3.7–6.6), lub neej nruab nrab tag nrho (mOS) 8.8 lub hlis (95% CI 7.1–10.2); 96.9% tsuas muaj Qib 1–2 CRS xwb, tsis muaj Qib 3+ CRS lossis kev tuag ntsig txog.

• Cov Ntaub Ntawv Kho Mob Thaum Ntxov ntawm HER2-CAR-T
  Kev tshawb fawb theem I thawj zaug hauv tib neeg tau qhia txog qhov kev nyab xeeb uas tswj tau; kev sim sau npe theem II tseem tab tom ua mus.

• Lub Platform Technology Ua Tus Thawj Coj
  BIOOCUS ua haujlwm rau lub chaw tsim khoom kho mob hlwb GMP-qib thoob ntiaj teb, ua kom muaj kev tsim khoom ntawm CAR-T cell zoo thiab sib xws.

• Pab Pawg Kws Tshaj Lij Ntau Yam Kev Kawm
  Peb pab neeg muaj cov kws tshwj xeeb hauv kev tiv thaiv kab mob, oncology, thiab kev kho mob hlwb, xa kev tswj hwm tus kheej tag nrho.

• Kev Paub Txog Kev Kho Mob Thoob Ntiaj Teb
  Peb tau kho cov neeg mob thoob plaws ntiaj teb, sau cov ntaub ntawv kev nyab xeeb thiab kev ua tau zoo.

• Kev Pabcuam Txhua Yam Thaum Kawg
  Txij li kev tsim cov txheej txheem thiab kev sib koom tes kho mob txawv teb chaws mus rau kev saib xyuas tom qab kev txhaj tshuaj mus sij hawm ntev, BIOOCUS muab kev txhawb nqa ib zaug xwb.