Te Whakaora CAR-T mō te Mate Pukupuku o te Kōpū

Ko Claudin18.2 (CLDN18.2) he isoform pūmua hononga piripono e whakaatuhia ana i roto i te epithelium puku, ā, he nui rawa te whakaaturanga i runga i te mata o ngā pūtau matepukupuku puku. Ko CT041 (waehere whanaketanga CG4006) he hua CAR-T autologous e aro ana ki te CLDN18.2. E whakaatu ana ngā raraunga Wāhanga I i te kaha ārai-pukupuku i roto i ngā tūroro matepukupuku puku kua tino rongoatia, he CLDN18.2-pai.

Ka kitea anō hoki te nui rawa o te HER2 i roto i tētahi rōpū iti o ngā tūroro matepukupuku puku. Kua whakaatuhia e ngā maimoatanga CAR-T e aro ana ki te HER2 te kaha ārai-pukupuku i roto i ngā rangahau haumanu-mua me ngā rangahau haumanu tōmua. Kei roto i ngā whakamātautau haumanu Wāhanga II te TAC01-HER2 a Triumvira Immunologics i tēnei wā.

• Te Whāinga Tino MotuhakeMā te tuku i ngā pūtau CAR-T ki te CLDN18.2, ki te HER2 rānei, ka taea te tautuhi tika me te whakakore i ngā pūtau matepukupuku o te puku, ka whakaitihia ngā pānga mai i waho o te pukupuku.

• Te wikitoria i te ātete ki te maimoatanga maha-rainaI roto i ngā whakamātautau CT041, i eke te rōpū matepukupuku puku ki te reiti urupare whāinga (ORR) o te 57.1%, te reiti whakahaere mate (DCR) o te 75.0%, me te oranga whānui (OS) o te 6-marama o te 81.2% i roto i ngā tūroro i rahua i ngā raina rongoā maha o mua.

• Ngā Urupare PūmauKo te roanga o te urupare mō te 6 marama i puta mai i te maimoatanga CLDN18.2-CAR-T he 44.8%, e whakaatu ana i te kaha ki te whai hua haumanu mō te wā roa.

• Te Whakaora WhaiaroMā te whakamahi i ngā pūtau-T o te tūroro ka whakaiti i te mōrearea o te whakakorenga, ā, ka whakarei ake i te haumaru me te whai huatanga.

• Kohinga Pūtau-T Toto Āpiti
  Ka wehea ngā pūtau-T i te toto ā-taha o te tūroro mā te leukapheresis.

• Te Hangarau Ira
  I roto i tētahi taiwhanga e tutuki ana i ngā whakaritenga GMP, ka whakawhitihia ngā pūtau-T hei whakaatu i tētahi CAR e aro ana ki te CLDN18.2, ki te HER2 rānei, kātahi ka whakawhanuitia ex vivo.

• Te Whakahauora i te Lymphodepleting
  Ka tukuna he rongoā whakarite o te cyclophosphamide me te fludarabine hei whakaiti i ngā lymphocytes taketake me te waihanga i tētahi āputa pai mō te whakawhānui i ngā pūtau CAR-T.

• Te Werohanga Pūtau CAR-T
  Ka werohia anō ngā pūtau CAR-T kua hangaia ki roto i te tūroro mā te uaua.

• Aroturuki me te Whakahaere
  Whai muri i te werohanga, ka tirotirohia tatatia ngā tūroro mō te mate tukunga cytokine (CRS) me te paitini roro, me te wawaotanga i te wā tika ina hiahiatia.

• Tātaritanga Wāhanga Tuatahi CT041 (CLDN18.2-CAR-T)
  I roto i ngā tūroro 37 i mua i te maimoatanga nui, i eke te rōpū matepukupuku puku ki te ORR 57.1%, DCR 75.0%; 94.6% i pāngia e te CRS Tau 1–2 anake, kāore he CRS Tau 3, teitei ake rānei, he paitini roro rānei; ko te roanga o te urupare e 6-marama ko te 44.8%.

• Ngā Hua Whakamutunga o te Wāhanga Tuatahi o Satri-cel (e aro ana hoki ki te CLDN18.2)
  I roto i te 98 o ngā tūroro matepukupuku puku he CLDN18.2-pai, ko te ORR he 38.8%, ko te DCR he 91.8%; ko te oranga kore-haere-ake toharite (mPFS) he 4.4 marama (95% CI 3.7–6.6), ko te oranga whānui toharite (mOS) he 8.8 marama (95% CI 7.1–10.2); 96.9% i pāngia e te CRS Taumata 1–2 anake, kāore he CRS Taumata 3+, he mate rānei e pā ana.

• Ngā Raraunga Hauora Moata HER2-CAR-T
  I whakaatuhia e te rangahau Wāhanga Tuatahi tuatahi i roto i te tangata he kōtaha haumaru ka taea te whakahaere; kei te haere tonu te whakamātautau rēhitatanga Wāhanga Tuarua.

• Pūhara Hangarau Ārahi
  Kei te whakahaerehia e BIOOCUS tētahi whare hanga rongoā pūtau taumata GMP o te ao, hei whakarite kia pai, kia pumau hoki te hanga pūtau CAR-T.

• Te Rōpū Tohunga Maha-mātauranga
  Kei roto i tā mātou tīma ngā tohunga mātau ki te rongoā ārai mate, te mate pukupuku, me te whakaora pūtau, e whakarato ana i te whakahaere whaiaro katoa.

• Wheako Hauora o te Ao
  Kua rongoatia e mātou ngā tūroro o te ao katoa, me te kohikohi i ngā raraunga whānui mō te haumaru me te whai huatanga.

• Ratonga Whānui mai i te Mutunga ki te Mutunga
  Mai i te hoahoa tikanga me te whakaritenga maimoatanga ki tāwāhi ki te whai i te maimoatanga roa i muri i te werohanga, ka tukuna e BIOOCUS te tautoko kotahi-mutunga.