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Te Whakaora i te Huaketo Oncolytic: Te Maimoatanga Matepukupuku Matatau
He pēhea te mahi a te rongoā huaketo oncolytic?
Ko tēnei rongoā e hangai ana i tētahi adenovirus momo 5 kua whakarerekētia kua hangaia ira hei:
- Whakaputa uri whiriwhiri i roto i ngā pūtau pukupukuKa aro nui te huaketo ki ngā pūtau matepukupuku, engari ka waiho ngā pūtau hauora, noa iho, kia kore e whara.
- Whakangaro tika i ngā pūtau matepukupukuI te whakaputa uri o te huaketo i roto i ngā pūtau pukupuku, ka pakaru, ka mate
- Whakahohehia tō pūnaha ārai mateMā te whakangaromanga o ngā pūtau matepukupuku ka tukuna ngā antigens pukupuku e whakaoho ana, e whakaohooho ana hoki i ngā parepare ā-tinana o tō tinana ki te whawhai ki te matepukupuku.
- Waihangahia he urupare ārai mate pumauKo tēnei tikanga rua—te whakamate tika i te huaketo me te whakahohenga ārai mate—e whakarato ana i te kaha kotahi-rua ki te whawhai ki te mate pukupuku
Ko wai ka whai hua mai i te rongoā huaketo oncolytic?
Tērā pea he pai te rongoā huaketo oncolytic mō ngā tūroro e whai ake nei:
Ngā Tohu kua Whakaaetia i nāianei:
- Matepukupuku tōngāmimi kore-uaua (NMIBC)kua rahua, kāore rānei e aro ki te maimoatanga BCG (Bacillus Calmette-Guérin)
- Ko ngā tūroro mate pukupuku tōngāmimi mōrearea-waenga ki te mōrearea-nui e rapu ana i ētahi atu huarahi hei whakakapi i te pokanga
Kei raro i te Tirotiro Hauora:
- Ngā momo pukupuku totoka kāore anō kia aro ki ngā maimoatanga paerewa
- Ngā mate pukupuku wahine e mau tonu ana, e hokihoki ana, e horapa ana rānei, tae atu ki:
- Matepukupuku o te kōpū
- Matepukupuku ovarian
- Matepukupuku tara
- Matepukupuku vulvar
- Ngā mate pukupuku o te puku
- Ētahi atu pukupuku totoka kua whanake
Te Whakahaere Maimoatanga
Te Tikanga mō te Matepukupuku Pūngāwerewere:
- Tikanga tukuTe whakaurunga tika o te pūkahukahu (te whakauru ki roto i te pūkahukahu)
- Horomanga75 mL o te otinga huaketo oncolytic (1×10¹⁰ IFU/mL)
- Te hōtaka maimoatanga:
-
- Wāhanga Whakataki: Ngā maimoatanga ia wiki mō te 1-6 wiki, i runga i te rōpū maimoatanga
- Wāhanga tiaki: Ngā maimoatanga ā-wā hei pupuri i te mana whakahaere o te mate
- Te roanga o te maimoatanga: Tae atu ki te 2 tau i runga i te urupare a te tangata takitahi
Ētahi atu Puku Totoka:
- Tikanga tukuWerohanga tika ki roto i te puku ki ngā pukupuku e taea te uru atu
- Inenga ritengaI runga i te rahi me te taunga o te pukupuku
- Ngā huringa maimoatangaE rima ngā rā karapīpiti mō ia huringa, me ngā huringa e whakahokia ana i runga i te urupare
Ngā mea hei tumanakohia i te wā e rongoatia ana
Te Whakarite i mua i te Maimoatanga:
Mō ngā tūroro matepukupuku tōngāmimi, ka whakauruhia he catheter, ā, ka whakaritea te tōngāmimi ki tētahi wai horoi ngawari i mua i te whakahaerenga o te huaketo oncolytic.
I te wā e Maimoatia ana:
- Ka whakahaerehia te tukanga katoa hei haerenga tūroro
- E tata ana ki te 1-2 hāora te roa o te whakaurunga o te pūkahukahu
- Me huri ngā tūnga o ngā tūroro i ia 15 meneti kia kitea katoatia ai te pakitara o te tōngāmimi.
- I muri i te wā pupuri, ka tukuna maoritia te otinga
Ngā Pānga Taha Noa:
Ko te rongoā huaketo oncolytic he pai te manawanui ki te nuinga. Ko ngā pānga taha tino kitea ko:
- Kirika(70% o ngā tūroro)—he ngawari noa iho, ā, ka taea te whakahaere mā te whakamahi i ngā rongoā paerewa
- Ngenge
- Ngā tohumate rite ki te rewharewha
- Te mamae ā-rohe i te wāhi werohanga, i te wāhi whakauru rānei
- Ngā tohu mimi rangitahi (mō ngā tūroro mate pukupuku pūkahukahu)
He mea nuiKo te nuinga o ngā pānga taha he taumata 1-2 (ngāwari ki te whakaōrite) ā, he rangitahi. He onge ngā pānga kino nui (iti iho i te 10% o ngā tūroro).
Ngā Taunakitanga Hauora
Ngā Hua o te Matepukupuku Pūkahukahu:
Kei roto tēnei rongoā huaketo oncolytic i ngā whakamātautau haumanu Wāhanga II mō te mate pukupuku pūkahukahu kāore e aro ki te BCG, me:
- 180 ngā tūroro kua whakaritea kia whakaurua
- He maha ngā pokapū maimoatanga puta noa i Haina
- Te aro turuki pakari i te haumaru me te whai huatanga
Ngā mate pukupuku wahine:
I whakaatuhia i roto i tētahi rangahau whakamuri o ngā tūroro 29 e pāngia ana e te mate pukupuku wahine pumau, e hokihoki mai ana, e horapa ana rānei:
- 40% te auau urupare katoa
- 80% te mana whakahaere ā-rohe katoa i te 3 marama
- Ngā urupare i kitea puta noa i ngā mate pukupuku o te kaki, te whatukuhu, te tara, me te vulvar
- Ko te roanga o te aroturukitanga waenga mō te 6.3 marama me te whakahaere tonu i te mate
- Neke atu i te 90% o ngā pānga taha he ngawari (Taumata 1-2)
Ngā Maimoatanga Huaketo Oncolytic rite tonu:
Kua whakaatuhia e ngā maimoatanga adenovirus oncolytic e pā ana (pēnei i te H101):
- Te whakaaetanga me te whakamahinga angitu i roto i ngā mate pukupuku o te upoko me te kaki i Haina mai i te tau 2005
- He hua pai ina honoa ki te chemotherapy me te radiation
- Te kaha ki te huri i ngā pukupuku kore e taea te mahi hei mate ka taea te tango mā te pokanga
Te urunga atu ki te Rongoā Huaketo Oncolytic i Haina i BIOOCUS
He tohunga mātou ki te hono i ngā tūroro o te ao ki ngā maimoatanga matatau e wātea ana i Haina, tae atu ki te rongoā huaketo oncolytic. Ka whakaratohia e mātou:
- Aromatawai whānuiAromatawai i tō tika mō tēnei maimoatanga
- Te whakarite hauoraTe hononga ki ngā pokapū mate pukupuku matua e whakahaere ana i ngā whakamātautau haumanu mō te huaketo oncolytic
- Te whakamahere maimoatangaTautoko katoa mō tō haerenga maimoatanga
- Tautoko reoNgā kaiwhakahaere hauora e kōrero Ingarihi ana puta noa i tō tiaki
- Te aroturuki tonuTe whakarite i te tiaki whai muri me ō tākuta kāinga
Ngā Mōhiotanga Haumaru Hira
Ko wai kāore e tika kia whiwhi i te rongoā huaketo oncolytic:
- Ngā tūroro e pāngia ana e te mate hepatitis B hohe, te HIV, te mate kohi rānei
- Ngā tūroro e hiahia ana ki ngā rongoā ārai mate
- Ngā wāhine hapu, ngā wāhine whāngai u rānei
- Ngā tūroro he nui te ngoikore o te ārai mate
Ngā Whakatūpato Motuhake:
- Ka whai ngā kaiwhakarato hauora me ngā mema o te whānau i ngā mahi ārai mate paerewa
- Kua hangaia te huaketo kia whakaputa uri noa i roto i ngā pūtau pukupuku, ā, kāore e horapa i waenga i te tangata
- Me whakamōhio ngā tūroro ki ngā kaiwhakarato hauora katoa mō tā rātou maimoatanga huaketo oncolytic.
Ngā Hipanga e Whai Ake Nei
Mena kua tāpaetia koe, tō whanaunga rānei, kei te mate pukupuku tōngāmimi, ā, kāore e aro ki te BCG, ki ētahi atu pukupuku totoka rānei e uaua ana ki te rongoā, tera pea ka puta he tumanako hou mā te rongoā huaketo oncolytic.
Hei mōhio mēnā kei te tika koe mō tēnei maimoatanga:
- Whakapā atu ki tā mātou tīma ratonga tūroro me ō pūkete hauora
- Whiwhi aromatawai whai mana tuatahi
- Whakaritea he hui kōrero ki ā mātou tohunga hauora
- Te whakawhanake i tētahi mahere maimoatanga whaiaro
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