NGĀ TĀTAI TAKE O NĀIANEI
CAR-T mō te Glioblastoma
Ko te Glioblastoma tētahi o ngā pukupuku roro tuatahi e kitea whānuitia ana, e werohia ana hoki i roto i ngā pakeke. Ka ahu mai i ngā pūtau glial i roto i te roro, ā, e mōhiotia ana mō tōna tipu tere me te āhua ki te uru ki roto i ngā kiko e karapoti ana, e uaua ai te tango katoa. Ko ngā tohu ka uru atu ki te ānini, te haurangi, ngā huringa hinengaro, me ngā ngoikoretanga pūnaha io, i runga i te wāhi o te pukupuku. Ahakoa ka taea e ngā maimoatanga paerewa te āwhina i te whakahaere i te mate, he maha ngā tūroro e rapu ana i ngā maimoatanga kua tohua hei whakapai ake i ngā putanga me te kounga o te oranga.
Te Whakaora CAR-T mō te Mate Pukupuku o te Kōpū
Ko te rongoā pūtau CAR-T he rongoā ārai mate whaiaro hou e whakamahia ana mō te rongoā i te mate pukupuku puku. Kua whakawhanakehia e BIOOCUS ngā hua CAR-T e aro ana ki ngā antigens motuhake ki te mate pukupuku puku pērā i a Claudin18.2 me HER2, e whakaatu ana i te whai huatanga nui i roto i ngā tūroro kua rahua i ngā maimoatanga maha o mua—hei tauira, i eke a CT041 ki te ORR o te 57.1%, DCR o te 75%, me te reiti oranga whānui 6-marama o te 81.2%. Mā te whakamahi i tētahi tūāpapa GMP-grade o te ao, he rōpū tohunga maha-mātauranga, me te wheako haumanu whānui o te ao, ka whakaratohia e BIOOCUS he otinga rongoā CAR-T haumaru, whai hua, me te whānui mō ngā tūroro mate pukupuku puku.
CAR-T mō te Lupus Erythematosus Pūnaha (SLE)
Ko te whakaora pūtau CAR-T (Chimeric Antigen Receptor T) he whakaora ārai mate hou kua whakaatu i te kaha ki te rongoā i te SLE mā te aro ki ngā pūtau B, he mea nui ki te pathogenesis o te mate. I roto i te SLE, ka whakaputa ngā pūtau B i ngā autoantibodies e whakaeke ana i ngā kiko o te tinana, ka arahi ki te mumura mau tonu me te kino o ngā okana. Ka mahi te whakaora CAR-T mā te hanga i ngā pūtau T hei whakaatu i tētahi kaiwhakawhiwhi (CAR) e aro ana ki te CD19, he tohu i runga i ngā pūtau B, ka arahi ki te whakangaromanga o ēnei pūtau B kino.
Ko ngā pūtau CAR-T e aro ana ki ngā pūtau CD19+ B ka whakarato i te whakahekenga pai ake me te pumau o ngā pūtau B ki te whakataurite ki ētahi atu maimoatanga, e aro ana ki te CD20 engari kāore e taea te whakakore i ngā pūtau plasma roa te ora. Ka taea e tēnei whakahekenga nui o ngā pūtau-B te arahi ki te murunga o ngā tohu SLE mā te whakakore i ngā pūtau e kawenga ana mō te hanga autoantibody. Ka tūhuratia hoki e ngā rangahau te CAR-Treg (ngā pūtau CAR-T i hangaia hei whakahaere i ngā urupare ārai mate) hei whakaora i te manawanui ārai mate me te whakaiti i te mahi auto-immune.
FUCASO: Te Whakaora BCMA CAR-T Tangata Katoa Hou me te Whai Huatanga me te Haumaru Kore e Taea te Whakakotahi
He rongoā CAR-T hou a FUCASO e aro ana ki te BCMA nā IASO BIO, e tuku ana i te whai huatanga me te haumaru tino pai mō te myeloma maha kua hoki mai, kua uaua rānei te whakatika. Me ngā reiti urupare teitei, te murunga roa, me te kōtaha haumaru pakari, ka whakaratohia e FUCASO he tumanako hou mō ngā tūroro, ā, ka whakatakoto i tētahi paerewa hou i roto i te rongoā CAR-T.
He Tirohanga Whānui mō te Maimoatanga Hou mō te Leukemia
Ko te CAR-T Therapy, he whakarāpopototanga mō te Chimeric Antigen Receptor T-Cell Immunotherapy, he tikanga whakaora ira matatau e uru ana ki te whakarerekē ira i ngā pūtau-T o te tūroro hei arotahi me te whakangaro i ngā pūtau matepukupuku. He rerekē ki ngā rongoā tuku iho, he mea whakarite te whakaora CAR-T ki ia tūroro, ā, me kohi ngā pūtau-T mai i te toto o te tūroro i mua i te whakahokinga mai ki roto i te tinana i muri i te hangarau ira.