Ngā Pātai Auau-Maimoatanga

P.
He aha te whakawhitinga toto me te hinu wheua (BMT)?

A.

Ko te whakawhitinga toto me te wheua he momo maimoatanga motuhake mō te hunga whai mate pukupuku, mate wheua rānei. I roto i te whakawhitinga toto me te wheua, ka tangohia ngā pūtau e kitea ana i roto i te wheua, ka whakaritea, ka whakahokia ki te tūroro, ki tētahi atu tangata rānei. Ko te whāinga o te whakawhitinga toto me te wheua he hoatu ki te tangata he pūtau wheua hauora i muri i te tangohanga o ō rātou ake wheua kino.

Kua whakamahia angitu ngā whakawhitinga toto me te hinu wheua mai i te tau 1968 hei rongoā i ngā mate pēnei i te leukemia, te lymphoma, te anemia aplastic, ngā mate ārai mate me ētahi mate pukupuku pūtau totoka.
P.
Kia pēhea te roa o te noho hōhipera mō te BMT?

A.
Mō te whakawhitinga wheua, e kiia ana ko te roa o te noho hōhipera he 4-6 wiki pea. Heoi, me noho koe ki roto i te tāone mō te iti rawa o te 6 marama nā te mea me whai tonu koe i te tirotiro ā-tinana i muri i te BMT.
P.
Ko wai ka whai hua mai i te whakawhitinga toto me te hinu wheua (BMT)?

A.
Ko ngā mate e whai ake nei te mea tino kitea ka whai hua mai i te whakawhitinga toto, wheua rānei:

- Ngā mate toto toto

- Te mate toto aplastic kino

- Ngā mate pukupuku lymphoid

- Myeloma maha

- Ngā mate ngoikore o te pūnaha ārai mate
P.
He aha te rongoā CAR-T?

A.
He maimoatanga hou te whakaora pūtau T kaiwhakawhiwhi antigen chimeric (CAR-T) mō ngā momo mate pukupuku. Ko te whakaaro he tango i ngā pūtau T o te tūroro, ka hanga ira i a rātou kia whakaatu i tētahi kaiwhakawhiwhi antigen chimeric (CAR) e mōhio ana ki tētahi antigen e pā ana ki te pukupuku (TAA). Nō reira, ina whakahokia mai ngā pūtau-T e whakaatu ana i te CAR ki te tinana o te tūroro, ka arotahi rātou, ka whakakore hoki i ngā pūtau pukupuku e whakaatu ana i te TAA.
P.
Ko ēhea ngā tūroro e whai hua ana i te CAR-T?

A.
Ko te whakamātautau haumanu CAR-T e pā ana ki ngā tūroro e pangia ana e te mate pukupuku toto nui (B-ALL), te mate pukupuku pūtau-B me te mate myeloma maha kua hoki mai anō te mate, kua kore rānei e kaha ki te rongoā matū.
P.
Kia pēhea te roa me noho tātou ki te hōhipera mō te CAR-T?

A.

E ono ki te waru wiki te roa o te whakamātautau haumanu CAR-T, kei te āhua o ia tūroro.
P.
He aha te tukanga maimoatanga mō te CAR-T?

A.
P.
E hia ngā CAR-T kua oti i a koe?

A.
Mai i te tau 2015, kua oti i a mātou te 300 ngā whakamātautau haumanu CAR-T mō te B-ALL kua hoki whakamuri, te lymphoma pūtau-B me te myeloma maha, ā, he tino pai ngā hua. I whakarapopototia e mātou ngā kēhi tuatahi e 51, ā, i whakaputaina ki te Journal of Leukemia i te tau 2017.
P.
He aha tō ōrau angitu mō te CAR-T?

A.
Neke atu i te 90% te ōrau murunga katoa.
P.
He aha ngā painga o te whai i tētahi whakawhitinga wheua (BMT) i muri i te CAR-T?

A.
Ahakoa he teitei te tere o te murunga katoa (CR) o te maimoatanga CAR-T, kei te tūpono tonu te hokinga mai o te mate. Kua whakaatuhia e ngā rangahau ko te hono i te BMT i muri i te CAR-T mō te B-ALL ka taea te whakanui ake i te tere o te whakaora.
P.
Me pēhea taku tiki i tētahi wā hui?

A.
Ka taea e koe te whakarite i tētahi wā hui mā roto i ā mātou māngai tari o te ao.
P.
Ko ēhea ngā tuhinga me mauria mai e au?

A.
He mea tino nui kia mauria mai e koe ngā tuhinga katoa e tika ana i a koe e haereere ana, tae atu ki ngā kape pepa o ngā pūrongo hauora katoa, ngā pūrongo pathology tae atu ki ngā kiriata karāhe me ngā poraka paraffin e hiahiatia ana mō te arotake, ngā hua whakaahua o te CT, MRI, PET-CT scan, te mahi toto, te histochemistry ārai mate, te whakamātautau ira, me ngā hua chromosome mēnā e wātea ana.
P.
Mā wai e whakahaere aku wā whakarite me te whakarite i aku wā i te hōhipera?

A.
Mā tā mātou tīma o te ao whānui koe e whakarite i ngā wā hui me te whakarite i ngā tirotiro whai muri i a koe i te hōhipera.
P.
He aha te tukanga e tika ana mā ngā tūroro ki te rapu tohutohu hauora?

A.
Ko tā mātou kaimahi o te Pokapū Ao he whakarato i te urunga māmā me te tiaki whaiaro mō ā mātou tūroro o tāwāhi. Ka wātea ā mātou kaimahi ki te āwhina i ngā tūroro katoa i ngā wāhanga katoa o tā rātou tiaki.
P.
Ka taea e au te tiki i taku pūrongo take i muri i te maimoatanga?

A.
Āe, i muri i te maimoatanga, ka whakamāoritia e mātou tō pūrongo take, ka tukuna atu hoki he pūrongo take ki a koe i te reo Pākehā me te reo Hainamana kia taea ai e koe te kawe mai ki tō whenua.
P.
Ka āwhina mai tetahi i ahau ki te haere ki te taunga rererangi ina hoki ahau ki te kāinga i muri i te maimoatanga?

A.
Āe, mā ngā kaimahi o te International Center koe e rāhui te waka, ā, mā rātou anō koe e āwhina ki te whakatakoto i ō tueke ki roto i te waka, me te kawe i a koe ki te taunga rererangi.