Imibuzo Ebuzwa Rhoqo-Unyango

Umbuzo.
Yintoni ukufakelwa igazi kunye nomongo wethambo (BMT)?

A.

Ukufakelwa igazi nomongo wethambo luhlobo olukhethekileyo lonyango kubantu abaneentlobo ezithile zomhlaza okanye ezinye iingxaki zomongo wethambo. Kukufakelwa igazi nomongo wethambo, iiseli ezifumaneka rhoqo kumongo wethambo ziyathathwa, zilungiswe kwaye zibuyiselwe kwisigulana okanye komnye umntu. Injongo yokufakelwa igazi nomongo wethambo kukunika umntu iiseli zomongo wethambo eziphilileyo emva kokuba umongo wethambo wakhe ongaphiliyo ususiwe.

Ukufakelwa igazi kunye nomongo wethambo kuye kwasetyenziswa ngempumelelo ukususela ngo-1968 ukunyanga izifo ezifana ne-leukaemia, i-lymphoma, i-aplastic anemia, iingxaki zokungasebenzi kakuhle kwamasosha omzimba kunye neminye imidlaza ye-tumor eqinileyo.
Umbuzo.
Ingakanani ixesha eliqikelelweyo lokuhlala esibhedlele kwi-BMT?

A.
Ukufakelwa umongo wethambo kuqikelelwa ukuba ukuhlala esibhedlele kuthatha malunga neeveki ezi-4-6. Nangona kunjalo, kuya kufuneka uhlale kwisixeko ubuncinane iinyanga ezi-6 njengoko kufuneka ulandelelwano rhoqo emva kwe-BMT.
Umbuzo.
Ngubani onokungenelwa kukufakelwa igazi kunye nomongo wethambo (BMT)?

A.
Ezi zifo zilandelayo zezona zixhaphakileyo ekuzuzeni ngokufakelwa igazi okanye umongo wethambo:

- I-Leukaemias

- I-anemia enzulu ye-aplastic

- Iilymphomas

- I-myeloma emininzi

- Izifo zokunqongophala komzimba
Umbuzo.
Yintoni unyango lwe-CAR-T?

A.
Unyango lweeseli ze-Chimeric antigen receptor T (CAR-T) lunyango olutsha kwiintlobo ngeentlobo zomhlaza. Ingcinga kukususa iiseli ze-T zesigulane kunye nokuziyila ngokwezakhi zofuzo ukuze kuveliswe i-chimeric antigen receptor (CAR) eqonda i-antigen ethile enxulumene ne-tumor (TAA). Ngenxa yoko, xa iiseli ze-T eziveza i-CAR zibuyiselwa emzimbeni wesigulane, ziya kujolisa kwaye zisuse iiseli ze-tumor eziveza i-TAA.
Umbuzo.
Zeziphi izigulana ezixhamla kwi-CAR-T?

A.
Uvavanyo lweklinikhi lwe-CAR-T lujoliswe kwizigulane ezine-B-cell acute lymphoblastic leukaemia (B-ALL), i-B-cell lymphoma kunye ne-multiple myeloma eziye zabuyela okanye zayeka ukusebenzisa i-chemotherapy.
Umbuzo.
Sifanele sihlale ixesha elingakanani esibhedlele ukuze sifumane unyango lwe-CAR-T?

A.

Uvavanyo lweklinikhi lwe-CAR-T luthatha malunga neeveki ezi-6-8, oko kuxhomekeke kwimeko yesigulana ngasinye.
Umbuzo.
Iyintoni inkqubo yonyango lwe-CAR-T?

A.
Umbuzo.
Zingaphi iiCAR-T ozenzileyo?

A.
Ukususela ngo-2015, sigqibe malunga nama-300 eemvavanyo zeklinikhi ze-CAR-T ze-B-ALL ephinde yagula, i-B-cell lymphoma kunye ne-multiple myeloma eneziphumo ezibalaseleyo. Sishwankathele amatyala okuqala angama-51 saza sawapapasha kwiJournal of Leukemia ngo-2017.
Umbuzo.
Ingakanani izinga lempumelelo yakho kwi-CAR-T?

A.
Izinga lokuxolelwa ngokupheleleyo lilonke lalingaphezulu kwama-90%.
Umbuzo.
Iyintoni inzuzo yokufakelwa umongo wethambo (BMT) emva kweCAR-T?

A.
Nangona izinga lokuxolelwa ngokupheleleyo (CR) lonyango lwe-CAR-T liphezulu, kusekho umngcipheko wokubuyela umva. Izifundo zibonise ukuba ukuvala i-BMT emva kwe-CAR-T kwi-B-ALL kunokunyusa izinga lokunyanga elinokubakho.
Umbuzo.
Ndingayifumana njani idinga?

A.
Ungafumana idinga ngokusebenzisa abameli bamasebe ethu aphesheya.
Umbuzo.
Ngawaphi amaxwebhu endifanele ndiwaphathe?

A.
Kubaluleke kakhulu ukuba xa useluhambeni ube nawo onke amaxwebhu afanelekileyo akhoyo kuquka ikopi eprintiweyo yazo zonke iingxelo zonyango, iingxelo zezifo kuquka izilayidi zeglasi kunye neebhloko zeparafini eziya kufuneka ukuze kuhlolwe, iziphumo zomfanekiso we-CT, i-MRI, i-PET-CT scan, inkqubo yegazi, i-immune histochemistry, uvavanyo lwemfuza, iziphumo ze-chromosome ukuba ziyafumaneka.
Umbuzo.
Ngubani oza kujongana namadinga am kunye neshedyuli yam ngelixa ndisesibhedlele?

A.
Iqela lethu lamazwe ngamazwe liza kubhukisha ama-aphoyintimenti kwaye licwangcise ukulandelelwa kwakho ngelixa usesibhedlele.
Umbuzo.
Ithini inkqubo yokuba izigulane zifune iingcebiso zonyango?

A.
Abasebenzi bethu beZiko leHlabathi bajolise ekuboneleleni ngokufikelela okulula kunye nonyango olulungiselelwe wena kwizigulane zethu zamazwe ngamazwe. Abasebenzi bethu baya kufumaneka ukunceda bonke abaguli kuzo zonke izigaba zokhathalelo lwabo.
Umbuzo.
Ndingayifumana ingxelo yetyala lam emva konyango?

A.
Ewe, emva konyango, siza kuyiguqulela ingxelo yetyala lakho size sikunike ingxelo yetyala ngesiNgesi nangesiTshayina ukuze ukwazi ukuyibuyisela kwilizwe lakho.
Umbuzo.
Ngaba kukho umntu oza kundinceda ndiye kwisikhululo seenqwelo-moya xa ndibuya ekhaya emva konyango?

A.
Ewe, abasebenzi bethu beZiko leeHlabathi baya kubhukisha imoto baze bakuncede ufake imithwalo yakho emotweni baze bakuse kwisikhululo seenqwelo-moya.