- Unyango
- Ubungqina
- I-Neuroblastoma
- Ithumba Eliqinileyo
- Ubungqina
- Ii-TILS
- Unyango lweeSeli zeNK
- I-Myasthenia Gravis (MG)
- I-Acute Lymphoblastic Leukemia (B-ALL)
- I-Systemic Lupus Erythematosus (SLE)
- I-Acute Lymphoblastic Leukemia (T-ALL)
- I-NonHodgkin Lymphoma (NHL)
- I-Multiple Myeloma（MM）
- Ukusasaza i-B-cell Lymphom enkulu
- I-B-lymphocytic Leukemia
- I-Myeloma
I-CAR-T yeGlioblastoma
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Iseli ye-CAR-T
Unyango lwe-CAR-T (iChimeric Antigen Receptor T-cell) lumele uhlobo oluphambili lwe-immunotherapy. Lubandakanya ukuguqula ii-T cells zakho—uhlobo lweseli yomzimba—ukuze ziqaphele kwaye zihlasele iiseli zomhlaza ezibonisa iimpawu ezithile. Kwi-glioblastoma, olu nyango lujolise ekuboneleleni ngonyango olunokwandisa ukusinda nokunciphisa iimpawu, ingakumbi xa ludityaniswe nezinye iindlela.
Iithagethi kwi-CAR-T Therapy yeGlioblastoma
Kwi-glioblastoma, iiproteni ezithile kumphezulu weeseli zethumba zisebenza njengezona zinto zifanelekileyo zonyango lwe-CAR-T ngenxa yokubonakaliswa kwazo kakhulu kwiiseli zomhlaza kunye nokuba khona kwazo okuncinci kwizicubu ezisempilweni. KwiBioocus, sigxila kwiinjongo ezimbini eziphambili:
- GD2: Le yi-glycolipid antigen efumaneka rhoqo kwiiseli ze-glioblastoma, kunye nezinye iithumba zobuchopho ezifana ne-diffuse midline gliomas. I-GD2 ibandakanyeka ekudluliseleni imiyalezo kwiiseli kwaye ibonakaliswa kakhulu kwiithumba ezihlaselayo, nto leyo eyenza ukuba ibe luphawu oluthembisayo lokujonga amajoni omzimba.
- B7-H3: Ekwaziwa ngokuba yi-CD276, le protein yokujonga amajoni omzimba ifumaneka kakhulu kwi-glioblastoma kwaye inegalelo ekuphepheni ithumba kwinkqubo yomzimba yokuzikhusela. Idlala indima ekukhuthazeni ukukhula komhlaza kunye nokuthintela iimpendulo zomzimba, nto leyo eyenza ukuba ibe yindawo efanelekileyo yokuphucula uhlaselo lweeseli ze-T.
Ngokwenza iiseli ze-CAR-T zikwazi ukubona i-GD2 okanye i-B7-H3, unyango lukhokelela ekuhlaselweni okujoliswe kwiiseli zethumba ngelixa lunciphisa umonakalo kwizicubu eziqhelekileyo zobuchopho.
Indlela Unyango lwe-CAR-T Olusebenza Ngayo: Indlela Yokusebenza
Unyango lwe-CAR-T luqala ngokuqokelela isampuli yeeseli zakho ze-T ngenkqubo efana nokunikezelwa kwegazi. Ezi seli emva koko ziguqulwa ngokwemfuza kwilebhu ukuze ziveze i-chimeric antigen receptor (CAR)—i-receptor eyenzelwe wena esebenza njengesixhobo "sokuhlalisa" iiseli zomhlaza.
- Ukuqatshelwa: I-CAR kwiiseli ze-T ibopha ngokukodwa kwi-GD2 okanye kwi-B7-H3 kwiiseli ze-glioblastoma, njengesitshixo nesitshixo.
- Ukuvuselelwa: Nje ukuba ibotshelelwe, i-CAR ivuselela ii-T cells ukuba zisebenze, ziphindaphindeke, kwaye zikhuphe iimolekyuli ezibonisa ukuba ezinye iiseli zomzimba ziyabandakanyeka ekulweni.
- Intshabalalo: Iiseli ze-T ezisebenzayo zihlasela ngokuthe ngqo kwaye zibulale iiseli zomhlaza ekujoliswe kuzo, nto leyo enokubangela ukuncitshiswa kwethumba kunye nokunciphisa umthwalo wesifo.
Le nkqubo idla ngokubandakanya ukuphinda ufake ii-T cells eziguquliweyo emzimbeni wakho, rhoqo ngeendlela zokuhambisa ngemithambo okanye ezijoliswe ekufikeleleni engqondweni. Injongo kukudala impendulo yomzimba eqhubekayo eqhubeka nokujonga nokususa iiseli zomhlaza eziseleyo ngokuhamba kwexesha.
Unyango lwethu lwe-CAR-T lujolise kakhulu GD2 kwaye B7-H3 ngenxa I-Glioblastomabonisa ukusebenza okuthembisayo kwizilingo zeklinikhi.
Kwi-GD2 CAR-T, uphando lwezigulane ezingama-37 ezine-gliomas ezibuyela umva okanye ezinganyangekiyo lubonise ukuba Izinga lokuphendula ngokungakhethi cala elingama-72%, kunye Ama-42% afumana uxolelo olupheleleyo kwiiveki ezi-6 kwaye ama-56% ayigcina kwiminyaka eli-1.7 yokulandelelana.
Kwi-B7-H3 CAR-T, uvavanyo lwabantu abadala abangama-39 abane-glioblastoma ephindaphindayo lubike ukuba Izinga lokuphendula eliyi-30–40% kwaye Izinga lokulawula izifo ngama-60–70%, kunye ukusinda okuphakathi kweenyanga ezili-11 (i-monotherapy) kunye neenyanga ezili-13.6 (indibaniselwano), kudlula idatha yembali.
Zombini iindlela zonyango zikhuselekile, zineziphumo ebezingalindelekanga ezibuthathaka nezilawulekayo. I-Bioocus izinikele ekuphuculeni olu nyango lutsha ukuphucula iziphumo zezigulane ze-glioblastoma.
Unyango lweMisebe
Unyango lwe-radiotherapy olusebenzisa i-stereotactic (SRT) okanye unyango lomzimba olusebenzisa i-stereotactic radiotherapy (SBRT) ingadityaniswa ne-CAR-T ukujolisa ngqo kwiindawo ezinethumba, ukunciphisa ubungakanani kunye nokuphucula ukufikelela kwiiseli zomzimba. Le ndlela ichanekileyo inciphisa umonakalo kwizicubu ezisempilweni kwaye inokuphucula ukungena kwe-CAR-T.
Iinkqubo zokungenelela
Ukufakelwa kwamasuntswana kubandakanya ukubeka amasuntswana ane-radioactive ngqo kwi-tumor ukuze kufumaneke i-radiation yendawo, okuhambelana ne-CAR-T ngokwenza buthathaka iiseli zomhlaza kwangaphambili. Ukuze kufikelelwe kubuchopho, Ichibi lase-Ommaya Ukubekwa kwayo kuvumela ukuhanjiswa kweyeza ngqo kulwelo lwe-cerebrospinal, nto leyo enokunyusa ukusasazwa kwe-CAR-T.
Idama le-Ommaya
Esi sixhobo sikhethekileyo, sibekwe phantsi kwentloko ngotyando, ivumela ukuhanjiswa ngokuthe ngqo kwamayeza kulwelo lwe-cerebrospinal nge-catheter ukuya kwi-ventricles yobuchophoKwizigulane ze-glioblastoma, ingakumbi abo bane-leptomeningeal spread, i-Ommaya reservoir ivumela ukulawulwa ngokuchanekileyo kweeseli ze-CAR-T okanye ezinye iindlela zonyango, ukuqinisekisa ukuba amayeza aphezulu kwinkqubo yemithambo-luvo ephakathi kwaye akukho ntlungu ingako xa kuthelekiswa nokugqobhoka kwe-lumbar.
Esi sicwangciso seendlela ezininzi sijolise ekuphuhliseni ukwandisa ukulawula isifo ngelixa uxhasa ukuchacha kwakho kunye nempilo-ntle yakho.
Imibuzo ebuzwa qho
- Ngaba ndiyafaneleka ukufumana unyango lwe-CAR-T?Ukufaneleka kuxhomekeke kwizinto ezifana nohlobo lwethumba, unyango lwangaphambili, kunye nempilo iyonke. Ukubonisana neengcali zethu kunokukunceda ubone ukuba kufanelekile na kuwe.
- Zithini iziphumo ebezingalindelekanga ezinokubakho?Eziqhelekileyo ziquka ukudinwa, iimpawu ezinxulumene nokudumba, kunye neempendulo zomzimba, ezijongwa kwaye zilawulwa ngokusondeleyo.
- Ithatha ixesha elingakanani le nkqubo?Ukususela ekuqokeleleni iiseli ukuya ekufakweni, kudla ngokuthatha iiveki ezininzi, kunye nonyango olulandelayo oluqhubekayo.
Ukuba ucinga Unyango lwe-CAR-T ngenxa i-glioblastoma, silapha ukukuxhasa ngenkathalo enovelwano nesekelwe kubungqina. Nxibelelana neqela lethu eBioocus ukuze ucwangcise intlanganiso yokubonisana nokufunda indlela le ndlela intsha enokungena ngayo kwisicwangciso sakho sonyango. Impilo yakho nethemba lakho zibalulekile kuthi—makhe sihlolisise iindlela kunye.
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