Nā nīnau i nīnau pinepine ʻia-Lapaʻau

Q.
He aha ke ʻano o ka hoʻoili koko a me ka iwi iwi (BMT)?

A.

ʻO ke kāpili koko a me ka iwi he ʻano lapaʻau kūikawā no ka poʻe me kekahi mau ʻano maʻi kanesa a i ʻole nā maʻi iwi ʻē aʻe. I loko o kahi kāpili koko a me ka iwi, lawe ʻia nā pūnaewele i loaʻa maʻamau i loko o ka iwi, hoʻomākaukau ʻia a hāʻawi ʻia i ka mea maʻi a i ʻole kekahi kanaka ʻē aʻe. ʻO ka pahuhopu o kahi kāpili koko a me ka iwi, ʻo ia ke hāʻawi i kahi kanaka i nā pūnaewele iwi olakino ma hope o ka wehe ʻia ʻana o ko lākou iwi ponoʻī.

Ua hoʻohana pono ʻia nā hoʻoili koko a me ka iwi mai ka makahiki 1968 e mālama i nā maʻi e like me ka leukemia, lymphoma, anemia aplastic, nā maʻi immunodeficiency a me kekahi mau maʻi ʻaʻai puʻupuʻu paʻa.
Q.
He aha ka lōʻihi o ka noho ʻana ma ka haukapila i manaʻo ʻia no BMT?

A.
No ka hoʻoili iwi iwi, ua manaʻo ʻia ka noho ʻana ma ka haukapila ma kahi o 4-6 mau pule. Eia nō naʻe, pono ʻoe e noho i loko o ke kūlanakauhale no ka liʻiliʻi he 6 mau mahina no ka mea he pono ka nānā pinepine ʻana ma hope o ka BMT.
Q.
ʻO wai ka mea hiki ke pōmaikaʻi mai ka hoʻoili koko a me ka iwi iwi (BMT)?

A.
ʻO nā maʻi ma lalo nei ka mea maʻamau e loaʻa ai ka pōmaikaʻi mai ke koko a i ʻole ka iwi iwi:

- Nā maʻi leukemia

- Anemia aplastic koʻikoʻi

- Nā Lymphoma

- Myeloma lehulehu

- Nā maʻi pale ʻole
Q.
He aha ka lāʻau lapaʻau CAR-T?

A.
ʻO ka lāʻau lapaʻau cell Chimeric antigen receptor T (CAR-T) kahi lāʻau hou no nā ʻano maʻi kanesa like ʻole. ʻO ka manaʻo, ʻo ia ka wehe ʻana i nā cell T o ka mea maʻi a hoʻololi i ke ʻano genetic iā lākou e hōʻike i kahi chimeric antigen receptor (CAR) e ʻike ana i kahi antigen pili i ka tumor (TAA). ʻO ka hopena, ke hoʻokomo hou ʻia nā CAR-expressing T-cell i loko o ke kino o ka mea maʻi, e kuhikuhi lākou a hoʻopau i nā TAA-expressing tumor cell.
Q.
ʻO wai nā maʻi e pōmaikaʻi ana mai CAR-T?

A.
ʻO ka hoʻokolohua lapaʻau CAR-T no nā poʻe maʻi me ka B-cell acute lymphoblastic leukemia (B-ALL), B-cell lymphoma a me ka myeloma multiple i hoʻi hou a i ʻole kūʻē i ka chemotherapy.
Q.
ʻEhia ka lōʻihi e noho ai mākou ma ka haukapila no CAR-T?

A.

ʻO ka manawa o ka hoʻokolohua lapaʻau CAR-T ma kahi o 6-8 mau pule, ma muli ia o ke kūlana o kēlā me kēia mea maʻi.
Q.
He aha ke kaʻina hana no ka mālama ʻana iā CAR-T?

A.
Q.
ʻEhia mau CAR-T āu i hana ai?

A.
Mai ka makahiki 2015, ua hoʻopau mākou ma kahi o 300 mau hoʻokolohua lapaʻau CAR-T no ka B-ALL i hoʻihoʻi ʻia me ka maʻi paʻakikī, ka lymphoma B-cell a me ka myeloma maha me nā hopena maikaʻi loa. Ua hōʻuluʻulu mākou i nā hihia mua he 51 a paʻi iā lākou ma ka Journal of Leukemia i ka makahiki 2017.
Q.
He aha kāu helu kūleʻa CAR-T?

A.
ʻOi aku ka nui o ka hoʻōla piha ʻana ma mua o 90%.
Q.
He aha ka pōmaikaʻi o ka loaʻa ʻana o kahi hoʻoili iwi iwi (BMT) ma hope o CAR-T?

A.
ʻOiai ke kiʻekiʻe nei ka helu hoʻomaha piha (CR) o ka mālama ʻana iā CAR-T, aia nō ka pilikia o ka hoʻi hou ʻana. Ua hōʻike ʻia nā haʻawina e hiki i ka hoʻopili ʻana iā BMT ma hope o CAR-T no B-ALL ke hoʻonui hou aku i ka helu ho'ōla.
Q.
Pehea e loaʻa ai iaʻu kahi manawa?

A.
Hiki iā ʻoe ke loaʻa kahi manawa i hoʻonohonoho ʻia ma o kā mākou mau ʻelele o ka ʻoihana honua.
Q.
He aha nā palapala e pono iaʻu e lawe pū me aʻu?

A.
He mea nui loa ia i ka wā e huakaʻi ana e loaʻa iā ʻoe nā palapala pili āpau me ʻoe e komo pū ana me ke kope paʻa o nā hōʻike lapaʻau āpau, nā hōʻike pathology e like me nā paheʻe aniani a me nā poloka paraffin e pono ai no ka loiloi ʻana, nā hopena kiʻi o CT, MRI, PET-CT scan, ka hana koko, ka histochemistry immune, ka hoʻāʻo genetic, nā hopena chromosome inā loaʻa.
Q.
ʻO wai ka mea nāna e mālama i kaʻu mau manawa i hoʻopaʻa ʻia a me ka hoʻonohonoho ʻana i koʻu wā ma ka haukapila?

A.
E hoʻonohonoho kā mākou hui honua i nā manawa a hoʻonohonoho i nā hālāwai nānā no ʻoe ʻoiai ʻoe ma ka haukapila.
Q.
He aha ke kaʻina hana no nā maʻi e ʻimi ai i ka ʻōlelo aʻo lapaʻau?

A.
ʻO ka pahuhopu o kā mākou limahana o ke Kikowaena Honua e hāʻawi i ke komo maʻalahi a me ka mālama pilikino no kā mākou mau maʻi o ka honua. E mākaukau kā mākou limahana e kōkua i nā maʻi āpau i nā pae āpau o kā lākou mālama.
Q.
Hiki iaʻu ke kiʻi i kaʻu hōʻike hihia ma hope o ka mālama ʻia ʻana?

A.
ʻAe, ma hope o ka mālama ʻia ʻana, e unuhi mākou i kāu hōʻike hihia a hāʻawi iā ʻoe i kahi hōʻike hihia ma ka ʻōlelo Pelekania a me ka ʻōlelo Kina i hiki iā ʻoe ke hoʻihoʻi mai i kou ʻāina.
Q.
E kōkua mai anei kekahi iaʻu e hele i ke kahua mokulele ke hoʻi au i ka home ma hope o ka mālama ʻana?

A.
ʻAe, e hoʻopaʻa kā mākou limahana o ke Kikowaena Honua i ke kaʻa a kōkua iā ʻoe e kau i kāu ukana i loko o ke kaʻa a lawe iā ʻoe i ke kahua mokulele.