ʻO ka lāʻau lapaʻau CAR-T no ka Lymphoma Non-Hodgkin (NHL)

ʻO ka Non-Hodgkin Lymphoma (NHL) kahi hui like ʻole o nā maʻi kanesa koko e hoʻomaka ana i loko o ka ʻōnaehana lymphatic, me nā ʻano ʻano like ʻole, me nā lymphomas B-cell a me T-cell. Ma waena o kēia mau mea, ʻO ka Lymphoma B-Cell Nui i hoʻolaha ʻia (DLBCL) ʻo ia ke ʻano maʻamau a me ka huhū o ka NHL B-cell. ʻOiai ka holomua ʻana i ka chemotherapy a me ka immunotherapy, nui nā maʻi me ka NHL relapsed a refractory paha e hakakā nei me nā koho lapaʻau palena. Ka lāʻau lapaʻau CAR-T hāʻawi i kahi ala holomua, e hāʻawi ana i ka manaʻolana no nā poʻe maʻi i pane ʻole ʻia kā lākou lymphoma i nā lāʻau lapaʻau kuʻuna.

ʻO ka lāʻau lapaʻau CAR-T (Chimeric Antigen Receptor T-cell) he immunotherapy kipi e pili ana i ka hoʻololi ʻana i nā T-cell o ka mea maʻi e hōʻike i kahi receptor e kuhikuhi ana i nā cell cancerous. No NHL, kuhikuhi nui ka lāʻau lapaʻau CAR-T CD19 a me CD20 nā antigens ma nā pūnaewele B, i loaʻa pinepine ʻia ma nā pūnaewele lymphoma malignant. Ma ka hoʻonui ʻana i ka hiki o nā pūnaewele T ke ʻike a hoʻouka i kēia mau pūnaewele kanesa, hāʻawi ka lāʻau lapaʻau CAR-T i kahi koho lapaʻau kūpono no nā poʻe maʻi me ka lymphoma relapsed a refractory paha.

• Kūpono no ka NHL Relapsed a me RefractoryUa hōʻike ʻo CAR-T i ka hopena maikaʻi loa i nā poʻe maʻi me DLBCL a me nā ʻano ʻē aʻe o B-cell NHL i pane ʻole i nā laina lapaʻau he nui.
• Pololei i Hoʻolālā ʻiaHoʻopili ka lāʻau lapaʻau i nā cell-B maʻi kanesa me ka ʻole o ka hōʻeha ʻana i nā cell olakino, e hōʻemi ana i nā hopena ʻaoʻao e pili pinepine ʻia me nā lāʻau lapaʻau kuʻuna.
• Lapaʻau pilikinoHoʻohana ka lāʻau lapaʻau CAR-T i nā pūnaewele T ponoʻī o ka mea maʻi, e hāʻawi ana i kahi ʻano lapaʻau maʻamau i hoʻopilikino ʻia i ke kūlana kikoʻī o kēlā me kēia kanaka.
• Ka hiki ke kala ʻia no ka wā lōʻihiUa loaʻa i nā maʻi he nui ke kala piha a hapa paha ma hope o ka lāʻau lapaʻau CAR-T, me kekahi e mālama nei i ke ola lōʻihi, ʻoiai ma hope o nā manawa he nui o ka chemotherapy.

• Hōʻiliʻili kelepona-TʻOhi ʻia nā pūnaewele T mai ke koko o ka mea maʻi ma o ke kaʻina hana i kapa ʻia ʻo leukapheresis, e like me ka hāʻawi koko.
• Ke hana ʻenekinia ʻana i nā pūnaewele TMa ka hale hana, ua hoʻololi ʻia nā pūnaewele T i hōʻiliʻili ʻia i ka genetically e hōʻike i nā mea loaʻa e kuhikuhi ana i nā antigens kikoʻī e like me CD19 a i ʻole CD20 i loaʻa ma nā pūnaewele lymphoma.
• Hoʻokomo ʻia ʻo CAR-TKe hoʻonui ʻia a hoʻololi ʻia nā pūnaewele T, hoʻihoʻi ʻia lākou i loko o ke kahe koko o ka mea maʻi e hoʻouka i nā pūnaewele lymphoma.
• Ka Nānā ʻana a me ka Hoʻōla ʻanaMa hope o ke kāwili ʻana, nānā ʻia nā mea maʻi no nā hopena ʻaoʻao, e like me ka cytokine release syndrome (CRS) a me ka neurotoxicity, hiki ke mālama ʻia nā mea ʻelua me ke kōkua lapaʻau kūpono.

• ʻEnehana CAR-T Hou LoaHoʻohana ʻo BIOOCUS i ka ʻenehana CAR-T holomua loa e hāʻawi i ka lāʻau lapaʻau holomua loa a maikaʻi hoʻi no NHL, me ka hoʻohana ʻana i ka noiʻi hou loa e hōʻoia i nā hopena maikaʻi loa.
• ʻO ka hui Hematology akamaiHana pū kā mākou hui multidisciplinary o nā hematologists, oncologists, a me nā loea immunotherapy e hāʻawi i nā hoʻolālā lapaʻau pilikino no kēlā me kēia maʻi.
• Ua hōʻoia ʻia ka holomua i ka mālama ʻana iā DLBCLUa mālama ʻo BIOOCUS i nā maʻi NHL he nui me ka lāʻau lapaʻau CAR-T, a ua hoʻokō i nā pane kupaianaha, me ke kala piha ʻana a me ke ola mau loa, ʻoi aku hoʻi i nā maʻi me ka DLBCL relapsed a refractory paha.
• Kākoʻo Maʻi HoloʻokoʻaMai ke kūkākūkā mua ʻana a hiki i ka mālama ma hope o ka mālama ʻana, hāʻawi ʻo BIOOCUS i ke kākoʻo piha i nā poʻe maʻi o ka honua, e hōʻoiaʻiʻo ana i kahi huakaʻi maʻalahi a kākoʻo hoʻi i kā lākou kaʻina hana lapaʻau.

• Ua hōʻike ka lāʻau lapaʻau CAR-T no NHL, ʻoi aku hoʻi no DLBCL, i nā hopena kupaianaha i nā hoʻokolohua lapaʻau a me nā noi honua maoli. No nā poʻe maʻi i loaʻa i nā laina he nui o ka lāʻau lapaʻau me ka holomua ʻole, ua hōʻoia ʻia ka lāʻau lapaʻau CAR-T he koho hoʻōla ola.

  • Ka Moʻolelo o ka Mea Maʻi: Diffuse Large B-Cell Lymphoma (DLBCL)—He Hoʻōla Kupaianaha Ma hope o ka Lapaʻau CAR-T
  • Holomua Lapaʻau: CAR-T Therapy no ka DLBCL Relapsed—He Ala e Hoʻopau Loa ai i ke Kala ʻana
  • DLBCL Palekana Multi-Line: He Haʻawina Hihia o ka Pono o ka CAR-T Therapy ma ka Lymphoma Kiʻekiʻe

  Hōʻike kēia mau haʻawina hihia i ka hiki ke hoʻololi i ka lāʻau lapaʻau CAR-T no nā poʻe maʻi me NHL, ʻoiai ka poʻe me ka DLBCL kū'ē i ka maʻi a me ka multi-line. Ua loaʻa i nā poʻe maʻi he nui ke kala ʻana no ka manawa lōʻihi a ua loaʻa hou ke ʻano o ke ola ma hope o ka mālama ʻana.

Nā hōʻailona no CD19+20CAR-T:Nā maʻi me ka lymphoma B-cell non Hodgkin

Nā hōʻailona no CD19+22CAR-T:Ka mālama ʻana i nā maʻi leukemia B-lymphocytic acute i hoʻihoʻi ʻia mai ka CD19 a me ka refractory

Nā hōʻailona no BCMACAR-T:Ka mālama ʻana i ka myeloma maha relapsed a me ka refractory