Ka Lanakila o Madhavan: Ke Lanakila ʻana i ka Glioma o ka Lolo me ka Bioocus B7H3 CAR-T Therapy

Ka Moʻolelo o ka Mea Maʻi

Ua ʻike ʻia ʻo Madhavan me ka glioma o ka lolo, kahi puʻupuʻu ʻino i ʻike ʻia no kona komo ʻana a me ka prognosis maikaʻi ʻole. I ka makahiki 58, ma hope o ka hāʻule ʻana o nā lāʻau lapaʻau maʻamau e like me ke ʻoki ʻana a me ka radiation, ua huli ʻo ia iā Bioocus no nā koho holomua. Ua kuhikuhi ʻia i ka Halemai Tumor Tianjin ʻo Konggang Hospital, ua kākau inoa ʻo ia i kā mākou papahana B7H3 CAR-T ma lalo o ka helu lāʻau P001. Hōʻike nui ʻia ʻo B7H3 ma nā pūnaewele glioma, e lilo ia i pahuhopu kūpono no nā pūnaewele T i hana ʻia ma o ka wai cerebrospinal (CSF) e hoʻouka pololei i ka puʻupuʻu.

Ka Huakaʻi Lapaʻau

ʻO ka lāʻau lapaʻau a Madhavan i pili i ka hoʻokomo ʻana i nā pūnaewele CAR-T autologous i loko o ka CSF, me ka nānā ʻana ma o nā loiloi CSF serial mai ka Lā 2 (D2) a i ka Lā 28 (D28).

• D2 (ʻAukake 8, 2025):Loaʻa mua ka ikaika me B7H3 CAR-T ma 54.44% o nā pūnaewele CD3+ T.
• D4 (ʻAukake 11, 2025):52%, e hōʻike ana i nā dinamika mua.
• D7 (ʻAukake 14, 2025):Ua piʻi aʻe i ka 59.51%.
• D10 (ʻAukake 17, 2025):12%.
• D14 (ʻAukake 21, 2025):19%.
• D21 (ʻAukake 28, 2025):Ua piʻi i ka 89.69%, e hōʻike ana i ka hoʻonui kupaianaha.
• D28 (Kepakemapa 6, 2025):Hoʻopaʻa ʻia ma 13.58% o nā pūnaewele CD3+ T, me 11.90% ma CD4+ a me 14.28% ma nā ʻāpana CD8+. Ma keʻano holoʻokoʻa, ua lanakila nā pūnaewele CD3+ T ma 95.34%, me ke kiʻekiʻe o ka CD8+ (66.74%) e hōʻike ana i ka cytotoxicity ikaika.

Ua hōʻike nā kiʻi hoʻonui i ka neʻe ʻana akā paʻa mau ka hoʻomau ʻana o CAR-T, he mea nui no ka kaohi mau ʻana o ka maʻi puʻupuʻu i loko o ka CNS.

Nā Hopena Koʻikoʻi

ʻO ka hoʻonui kiʻekiʻe o ka piko ma D21 e pili ana me ka emi ʻana o ka puʻupuʻu ma MRI, e alakaʻi ana i kahi pane hapa e D28 a me ka hoʻomaikaʻi mau ʻana. Hoʻemi kēia lawe ʻana intrathecal i nā hopena ʻaoʻao systemic me ka hoʻonui ʻana i ka pono e kūʻē i nā gliomas, me kā mākou ʻikepili e hōʻike ana i ka hoʻomaikaʻi ʻana i ke ola ʻana me ka ʻole o ka holomua. Ua hōʻike ʻo Madhavan i nā hōʻailona hiki ke hoʻokele ʻia a ʻaʻohe neurotoxicity koʻikoʻi.