Ka maʻi ʻaʻai ovarian-03

ʻO Ms. K, he wahine 55 makahiki me kahi kūlana waiwai i noho ma waho, ua kū koke ʻo ia i ka maʻi kanesa. ʻEkolu mau makahiki i hala aku nei, ua ʻike ʻo ia i ka ʻeha a me ka pehu ʻana ma kona ʻōpū lalo, me ka emi ʻana o ka makemake e ʻai. I ka nānā ʻana ma kahi haukapila haole, ua ʻike ʻia ʻo ia he maʻi kanesa ovarian pae IV. Ma muli o ke kahua holomua a me nā ʻōpū he nui i loaʻa i ka wehe ʻana i ka ʻōpū, ʻaʻole hiki ke wehe ʻia ke ʻoki ʻana, waiho wale ʻia ka chemotherapy ma ke ʻano he koho.

Ma hope o ke ʻoki ʻana, ua piʻi ka māka tumor CA125 i loko o kāna serum mai 1800 U/mL a i ʻoi aku ma mua o 5000 U/mL. Ua hōʻike ka chemotherapy hoʻomau i ka liʻiliʻi o ka hopena, me ka piʻi hou ʻana o CA125 a i ʻoi aku ma mua o 8000 U/mL ʻeono mahina ma hope. Ua hoʻomaopopo nā kauka i kona ʻohana ua kaupalena ʻia kona manawa i koe a ua aʻo aku iā lākou e hoʻomākaukau noʻonoʻo. ʻOiai ke aʻo ʻana i ke koʻikoʻi o kona kūlana, ʻaʻole i hōʻike ʻo Ms. K i nā hōʻailona o ka manaʻolana ʻole. Ma mua o ka haʻalele ʻana i ka manaʻolana, makemake ʻo ia e hoʻāʻo i ka immunotherapy.

I ka makahiki i hala, ua hana ʻia ʻo Ms. K i kāna ʻoki kino mua no ka laʻana. Ma hope o ʻelua mahina o ka hoʻonui ʻana ex vivo, ua hoʻokomo hou ʻia nā TIL i loko o kona kino. Ua loaʻa iā ia ke kuni i ka lā o ka hoʻokomo ʻana, a ua emi iho ia i ka lā aʻe, a ua ʻoi aku ka maikaʻi o kona manaʻo ma ke ʻano holoʻokoʻa. I kēia manawa, ma hope o ʻeono mahina o ka mālama ʻana, ua noho mau kāna mau pae CA125 ma lalo o 18 U/mL. Hōʻike nā hoʻohālikelike kiʻi PET-CT ʻaʻole i koe kekahi o nā puʻupuʻu metastatic mua he 24 ma kona kino holoʻokoʻa. I Malaki o kēia makahiki, ua hana ʻia ʻo Ms. K i kahi ʻoki kino ʻelua no ka laʻana.