Matepukupuku ovarian-03

Ko Whaea K, he wahine 55 tau te pakeke, he tangata whai rawa, i noho ki tāwāhi, ā, i pāngia e te mate pukupuku. E toru tau ki muri, i pāngia ia e te mamae me te pupuhi i roto i tōna puku o raro, me te heke o te hiahia kai. I te tirotiro i tētahi hōhipera o tāwāhi, i kitea he mate pukupuku whatukuhu wāhanga tuawhā tōna. Nā te mea kua tino matatau te wāhanga me te maha o ngā pukupuku i kitea i te whakatuwheratanga o te puku, kāore i taea te tango pokanga, ko te chemotherapy anake te huarahi.

I muri i te pokanga, i piki ake te tohu pukupuku CA125 i roto i tana serum mai i te 1800 U/mL ki te neke atu i te 5000 U/mL. I whakaatu te haere tonu o te chemotherapy i te iti o te whai huatanga, ā, i piki anō te CA125 ki te neke atu i te 8000 U/mL i muri i ngā marama e ono. I whakamōhio ngā tākuta ki tōna whānau he iti noa te wā e toe ana ki a ia, ā, i tohutohu rātou kia rite te hinengaro. Ahakoa te mōhio ki te kaha o tōna āhua, kāore a Whaea K i whakaatu i ngā tohu o te ngakau pouri. I mua i tana tukunga i te tumanako, i hiahia ia ki te whakamātau i te immunotherapy.

I te tau kua hipa, i pokanga tuatahi a Whaea K mō te tango tauira. I muri i ngā marama e rua o te whakawhānui ex vivo, ka whakaurua anō ngā TIL ki roto i tōna tinana. I pāngia ia e te kirika i te rā i werohia ai, ā, i heke iho i te rā i muri mai, ā, kua pai ake ia i te nuinga. Ināianei, i muri i ngā marama e ono o te maimoatanga, kua noho tonu ōna taumata CA125 ki raro iho i te 18 U/mL. E whakaatu ana ngā whakataurite whakaahua PET-CT, kotahi anake te toenga o ngā pukupuku 24 taketake kua horapa puta noa i tōna tinana. I te marama o Poutū-te-rangi o tēnei tau, i pokanga tuarua a Whaea K mō te tango tauira.