He tangata pakari nō Īnia e whawhai ana ki te mate pukupuku puku

Tērā tētahi tangata manawanui, ko Thirandas Shiva Prasad tōna ingoa. E 32 ōna tau, ā, nō Īnia ia. He aha tātou ka whakanui ai i tōna ngākau nui? Anei tana kōrero whakamiharo.

I te tau 2023 i kitea te mate pukupuku puku o Thirandas, ā, i puta mai he mamae puku, ā, i whakaūtia ko te adenocarcinoma pūtau mowhiti tohu iti te taumata. I whai ia i te chemotherapy neoadjuvant me te tikanga FLOT, ā, i muri mai ka pokanga tae atu ki te tango gastrectomy iti. Ahakoa ngā maimoatanga i muri i te pokanga, i hoki mai te mate pukupuku me te horapa ki te pelvis, ka puta he raruraru pēnei i te hydronephrosis, te abscess, me te aukati. He maha ngā wawaotanga i pā ki a ia, tae atu ki te dialysis, te stenting, me te chemotherapy anō me te nab-paclitaxel, nivolumab, irinotecan, me ētahi atu. I te tau 2025, i whakaatuhia e ngā matawai PET-CT te haere whakamua me te pikinga o ngā whara puku me te ascites, ka waiho ia me hiahia ki ngā kōwhiringa auaha.

I a ia e rapu ana i te tiaki matatau, ka tahuri a Thirandas ki a BIOOCUS. I tukuna e tā mātou tīma tohunga he aromatawai tuatahi kore utu, i arotake i tana hītori whānui, ā, i tūtohu kia whakamahia te rongoā pūtau CLDN18.2 CAR-T, i whakaritea kia rite ki te āhua o tana pukupuku. I muri i te whakatikatika i mua, i whakahaerea pai te werohanga i roto i tā mātou whare matatau. Ahakoa ngā wero tuatahi pērā i te kirika me te mate pea, i whakahaere pai tā mātou tīma maha-mātauranga i ngā tohu me ngā paturopi me te tiaki tautoko, me te whakarite kia kore he CRS kino. I whakahaerea ngā tikanga pērā i te tango i te wai i roto i te puku me ngā whakatikatika stent me te tika, ā, i hua ake ai te whakaora i ngā tohu me ngā hua pai o te pathology i muri i te maimoatanga.

E tū motuhake ana a BIOOCUS mō āna ratonga tino pai me āna hua auaha. Ko tā mātou rongoā CAR-T, e aro ana ki te CLDN18.2, ka whakarato i tētahi whakaekenga arotahi ki ngā pūtau matepukupuku, ā, he maha ngā wā ka angitu i ngā wā e kore ai e angitu ngā rongoā tuku iho. He tino pai ngā ratonga tūroro ki te whakarite i ngā haerenga ki tāwāhi, ki te whakarato i te aro ki ngā ahurea, me te tuku i te aroturuki whānui, me te kore he taumahatanga tāpiri. E mihi ana a Thirandas ki ngā kaimahi aroha me ngā tukanga whai hua i huri i tētahi wheako whakamataku hei wheako tumanako.