Murume akatsunga wekuIndia anorwisa kenza yemudumbu

Kune murume akashinga anonzi Thirandas Shiva Prasad. Ane makore makumi matatu nemaviri ekuberekwa, uye anobva kuIndia. Sei tichiratidza kutsunga kwake? Heino nyaya yake inoshamisa.

Thirandas akaonekwa aine kenza yemudumbu muna 2023, achiratidza kurwadziwa mudumbu uye akasimbiswa kuti aive ne signet ring cell adenocarcinoma. Akaitwa chemotherapy ye neoadjuvant neFLOT regimen, zvichiteverwa nekuvhiyiwa kusanganisira subtotal gastrectomy. Pasinei nekurapwa mushure mekuvhiyiwa, kenza yakadzokazve ne metastases muchiuno, zvichikonzera matambudziko akadai se hydronephrosis, mabundu, uye obstructions. Akatsungirira kupindira kwakawanda, kusanganisira dialysis, stenting, uye mamwe chemotherapy ne nab-paclitaxel, nivolumab, irinotecan, nezvimwewo. Pakazosvika 2025, PET-CT scans yakaratidza kufambira mberi nekuwedzera kwemaronda emudumbu uye ascites, zvichimusiya achida dzimwe nzira itsva.

Achitsvaga rubatsiro rwepamusoro, Thirandas akatendeukira kuBIOOCUS. Chikwata chedu chenyanzvi chakapa ongororo yekutanga yemahara, vachiongorora nhoroondo yake yakakura uye vachikurudzira kurapwa kwemasero eCLDN18.2 CAR-T, kwakagadzirirwa chimiro chebundu rake. Mushure mekugadziriswa, kuiswa kwemushonga kwakaitwa zvakanaka muchipatara chedu chepamusoro. Pasinei nematambudziko ekutanga akadai sefivha uye hutachiona hunogona kuitika, timu yedu yehunyanzvi hwakasiyana-siyana yakakwanisa kubata zviratidzo zvinobudirira nemishonga inorwisa mabhakitiriya uye rubatsiro rwekutsigira, ichiva nechokwadi chekuti hapana CRS yakanyanya. Maitiro akadai sekubuda kwemvura mudumbu uye kugadziriswa kwestent kwakaitwa nemazvo, zvichikonzera kuderedzwa kwezviratidzo uye mhedzisiro yakanaka yezvirwere mushure mekurapwa.

BIOOCUS inonyatsozivikanwa nebasa rayo repamusoro uye zvigadzirwa zvitsva. Kurapa kwedu kweCAR-T, kwakanangana neCLDN18.2, kunorwisa masero ekenza zvakananga, kazhinji kunobudirira apo mishonga yechinyakare inokundikana. Basa revarwere rinobudirira mukubatanidza kufamba kwenyika dzakasiyana-siyana, kupa kunzwisiswa kwetsika, uye kupa kuteverwa kwakazara, zvese pasina mutoro wekuwedzera. Thirandas anokoshesa vashandi vane tsitsi uye maitiro anoshanda zvakanaka akashandura chiitiko chinotyisa kuita tariro.