Indoda ezimisele evela eNdiya ilwa nomdlavuza wesisu

Kukhona indoda eqinile egama linguThirandas Shiva Prasad. Ineminyaka engu-32 ubudala, futhi ivela eNdiya. Kungani sigcizelela ukuzimisela kwayo? Nansi indaba yayo emangalisayo.

UThirandas watholakala enomdlavuza wesisu ngo-2023, eveza ubuhlungu besisu futhi kwaqinisekiswa ukuthi une-signet ring cell adenocarcinoma esezingeni eliphansi. Wenziwa i-neoadjuvant chemotherapy nge-FLOT regimen, kwalandela ukuhlinzwa okuhlanganisa nokuhlinzwa kwesisu okungaphansi. Naphezu kokwelashwa ngemva kokuhlinzwa, umdlavuza waphinde wavela nokuguqulwa kwezicubu ethangeni, okwabangela izinkinga ezifana ne-hydronephrosis, amathumba, kanye nokuvinjelwa. Wabhekana nokungenelela okuningi, okuhlanganisa i-dialysis, i-stenting, kanye ne-chemo eyengeziwe nge-nab-paclitaxel, i-nivolumab, i-irinotecan, nabanye. Ngo-2025, ukuskena kwe-PET-CT kwabonisa ukuqhubeka nokwanda kwezilonda zesisu kanye nama-ascites, okwamshiya edinga izinketho ezintsha.

Efuna ukunakekelwa okusezingeni eliphezulu, uThirandas waphendukela ku-BIOOCUS. Ithimba lethu lochwepheshe linikeze ukuhlolwa kokuqala kwamahhala, libukeza umlando wakhe obanzi futhi lincoma ukwelashwa kwamaseli e-CLDN18.2 CAR-T, okwenzelwe ukubonakaliswa kwesimila sakhe. Ngemva kokulungiswa kusengaphambili, ukufakwa kwenziwa kahle esikhungweni sethu esithuthukile. Naphezu kwezinselele zokuqala njengomkhuhlane kanye nokutheleleka okungenzeka, ithimba lethu lezifundo eziningi laphatha izimpawu ngempumelelo ngama-antibiotic kanye nokunakekelwa okusekelayo, ukuqinisekisa ukuthi akukho CRS enzima. Izinqubo ezifana nokuphuma kwamanzi esiswini kanye nokulungiswa kwe-stent zaphathwa ngokunemba, okwaholela ekunciphiseni izimpawu kanye nemiphumela emihle ye-pathology ngemuva kokwelashwa.

I-BIOOCUS ivelele ngenkonzo yayo esezingeni eliphezulu kanye nemikhiqizo emisha. Ukwelashwa kwethu kwe-CAR-T, okuhlose i-CLDN18.2, kunikeza ukuhlaselwa okuqondiwe kumaseli omdlavuza, okuvame ukuphumelela lapho ukwelashwa okuvamile kwehluleka khona. Izinsizakalo zeziguli zivelele ekuhlanganiseni ukuhamba kwamanye amazwe, ukuhlinzeka ngokuzwela kwamasiko, kanye nokunikeza ukulandelwa okuphelele, konke ngaphandle komthwalo owengeziwe. I-Thirandas iyazisa abasebenzi abanozwela kanye nezinqubo ezisebenzayo eziguqule isipiliyoni esesabekayo saba yithemba.