I-Metastatic melanoma-04

Isiguli uMnu. Li, owesilisa oneminyaka engu-45 ubudala, waqala ukuzwa ubuhlungu besisu obuqhubekayo kanye nokwehla kwesisindo ekuqaleni kukaMashi 2022. Ukuhlolwa okulandelayo esibhedlela sendawo kwaholela ekuxilongweni kwakhe ngo-Ephreli 2022 ene-melanoma esakazekile. Naphezu kokuzama izindlela eziningana zokwelapha ezivamile, okuhlanganisa ukuhlinzwa, ukwelashwa ngemisebe, kanye ne-chemotherapy, isimo sakhe saqhubeka nokuba sibi, kanti izimila zasakazekela esibindini nasemaphashini akhe.

Ngemva kwemizamo engaphumelelanga ngemithi yokwelapha ejwayelekile, uMnu. Li wafuna ezinye izindlela zokwelapha ngoDisemba 2022 ngeseluleko sezokwelapha. Ngemva kokubonisana kabanzi nokucwaninga, wanquma ukuzama indlela entsha yokwelapha nge-immunotherapy ebizwa ngokuthi i-Tumor-Infiltrating Lymphocyte (TILs).

Inqubo Yokwelapha ye-TILs:

1. Ukukhishwa Kwesampula Yesimila: NgoJanuwari 2023, uMnu. Li wahlinzwa kancane ukuze kukhishwe ingxenye yezicubu zesimila.

2. Ukwanda Kwe-Lymphocyte: Elabhorethri, abacwaningi bahlukanise ama-Lymphocyte Angena Emathunjini (ama-TIL) esampula yesimila esikhishwe. Lawa ma-lymphocyte anwetshwa izikhathi eziningi ngaphakathi kwe-vitro ukuze afinyelele inani elidingekayo lokwelashwa.

3. Ukulungiswa Kwe-Chemotherapy: Ngaphambi kokufakwa kwamaseli e-TIL, uMnu. Li wenziwa i-chemotherapy isikhathi esithile ukuze kuncishiswe inani lama-lymphocyte akhona emzimbeni wakhe, okwenza kube nendawo yamaseli e-TIL asanda kufakwa.

4. Ukufuthwa Kwamaseli e-TIL: NgoMashi 2023, amaseli e-TIL anwetshiwe aphinde afakwa emzimbeni kaMnu. Li ngokufuthwa ngemithambo yegazi.

5. Ukwelashwa Okusekelayo: Ukuze kuthuthukiswe umsebenzi we-TILs, uMnu. Li uphinde wathola imijovo eminingana ye-Interleukin-2 (IL-2).

Ezinyangeni ezalandela ukwelashwa, isimo sikaMnu. Li sathuthuka kakhulu. Izimila zancipha kakhulu, futhi izilonda ezasakazeka emzimbeni zabonisa ukukhululeka okuyingxenye. Ukulandelela ngoJuni 2023 kwembula ukuthi izimila esibindini nasemaphashini zazinyamalele cishe ngokuphelele. Impilo kaMnu. Li iyonke yaqala ukujwayela kancane kancane, isisindo sakhe sabuya, futhi ubuhlungu besisu sakhe bancipha.

"Lapho ngizwa ngesimo sami, kwaba sengathi umhlaba wonke uyawa. Ngemva kokuthola ukwelashwa okuningi okungasebenzi kahle, ngase ngicishe ngilahlekelwe yithemba. Ngenhlanhla, ngihlangane nokwelashwa kwe-TIL, okungagcinanga ngokusindisa impilo yami kodwa futhi kwabuyisela ithemba lami ngekusasa. Ngibonga bonke odokotela nabacwaningi abangisizile. Yimizamo yenu enginike ithuba elisha empilweni. Ngiyethemba ukuthi lokhu kwelashwa kungasiza iziguli eziningi ezinjengami ukuba zinqobe umdlavuza futhi zamukele impilo enempilo futhi."