I-Metastatic melanoma-04

Isigulana uMnu. Li, indoda eneminyaka engama-45 ubudala, waqala ukuba neentlungu zesisu ezingapheliyo kunye nokwehla kobunzima ekuqaleni kukaMatshi 2022. Uvavanyo olulandelayo kwisibhedlele sasekuhlaleni lwakhokelela ekuxilongweni kwakhe ngo-Epreli 2022 ene-metastatic melanoma. Nangona wayezama unyango oluqhelekileyo, oluquka utyando, unyango ngemitha, kunye ne-chemotherapy, imeko yakhe yaqhubeka nokuba mandundu, kunye neethumba ezisasazeka esibindini nasemaphaphu.

Emva kwemizamo engaphumelelanga yonyango oluqhelekileyo, uMnu. Li wafuna ezinye iindlela zonyango ngoDisemba ka-2022 emva kokufumana ingcebiso kagqirha. Emva kokubonisana kakhulu nophando, wagqiba ekubeni azame unyango olutsha olubizwa ngokuba yiTumor-Infiltrating Lymphocyte (TILs).

Inkqubo yoNyango lweTILs:

1. Ukukhutshwa kweSampulu yeTumor: NgoJanuwari 2023, uMnu. Li wenziwa utyando oluncinci ukuze kukhutshwe inxalenye yezicubu zetumor.

2. Ukwanda kweLymphocyte: Kwilabhoratri, abaphandi bahlukanise iiLymphocyte eziNgcwala iiTumor (iiTIL) kwisampulu yethumba ekhutshiweyo. Ezi lymphocyte zandiswa izihlandlo ezininzi kwi-vitro ukuze zifikelele kubungakanani obufunekayo bonyango.

3. Ukulungiswa kweKhemotherapy: Ngaphambi kokufakwa kweeseli zeTIL, uMnu. Li wenziwa ikhemotherapy kangangexesha elithile ukuze kuncitshiswe inani lee-lymphocytes ezikhoyo emzimbeni wakhe, nto leyo eyenza indawo yeeseli zeTILs ezisandula ukufakwa.

4. Ukufakwa kweeseli zeTILs: NgoMatshi 2023, iiseli zeTILs ezandisiweyo zabuyiselwa emzimbeni kaMnu. Li ngokufakwa ngemithambo yegazi.

5. Unyango oluxhasayo: Ukuphucula umsebenzi wee-TILs, uMnu. Li wafumana neenaliti ezininzi ze-Interleukin-2 (IL-2).

Kwiinyanga ezalandela unyango, imeko kaMnu. Li yaphucuka kakhulu. Iithumba zancipha kakhulu, kwaye izilonda ezasasazekayo zabonisa ukukhululeka okuncinci. Ukulandelelana ngoJuni ka-2023 kwatyhila ukuba iithumba esibindini nasemiphungeni zazinyamalale phantse ngokupheleleyo. Impilo kaMnu. Li iyonke yaqala ukuba yesiqhelo kancinci kancinci, ubunzima bakhe babuya, kwaye intlungu yesisu sakhe yaphela.

"Xa ndafumanisa ngemeko yam, ndaziva ngathi ihlabathi liphela liyawa. Emva kokufumana unyango oluninzi olungasebenziyo, ndandisele ndiphantse ndaphelelwa lithemba. Ngethamsanqa, ndidibene nonyango lwe-TILs, olungasindisanga ubomi bam kuphela kodwa nolubuyisele nethemba lam lekamva. Ndiyabulela kubo bonke oogqirha nabaphandi abandincedileyo. Yimizamo yenu endinike ithuba elitsha ebomini. Ndiyathemba ukuba olu nyango lunokunceda izigulane ezininzi ezifana nam ukuba zoyise umhlaza kwaye zamkele ubomi obusempilweni kwakhona."