Umhlaza wesibeleko-03

UNksz K, ibhinqa elineminyaka engama-55 ubudala elinobunewunewu obuthile elahlala phesheya, ngokungalindelekanga lajongana nomhlaza. Kwiminyaka emithathu eyadlulayo, lafumana ukungakhululeki kunye nokudumba esiswini salo esisezantsi, kunye nokuncipha kokutya. Emva kokuhlolwa kwisibhedlele sangaphandle, lafunyaniswa ukuba linomhlaza wesibeleko sesigaba sesi-4. Ngenxa yesigaba esiphambili kunye neethumba ezininzi ezifunyenwe xa kuvulwa isisu, ukususwa ngotyando kwakungenakwenzeka, kwashiya i-chemotherapy njengokhetho olulodwa.

Emva kotyando, uphawu lwe-tumor CA125 kwi-serum yakhe lwanda ukusuka kwi-1800 U/mL ukuya kwi-5000 U/mL. I-chemotherapy eqhubekayo yabonisa ukusebenza okuncinci, i-CA125 yanda kwakhona yaya kwi-8000 U/mL emva kweenyanga ezintandathu. Oogqirha bazise usapho lwakhe ukuba ixesha lakhe eliseleyo lilinganiselwe baza babacebisa ukuba balungiselele ngengqondo. Nangona befunde ubunzima bemeko yakhe, uNksz K akazange abonise zimpawu zokuphelelwa lithemba. Ngaphambi kokuba alahle ithemba, wayefuna ukuzama unyango lwe-immunotherapy.

Kunyaka ophelileyo, uNksz. K wenza utyando lwakhe lokuqala ukuze athathwe iisampulu. Emva kweenyanga ezimbini zokwandiswa kwe-ex vivo, ii-TIL zaphinda zafakwa emzimbeni wakhe. Waba nomkhuhlane ngomhla wokufakwa, owathi wehla ngosuku olulandelayo, waza waziva engcono kakhulu ngokubanzi. Ngoku, emva kweenyanga ezintandathu zonyango, amanqanaba akhe e-CA125 ahlala engaphantsi kwe-18 U/mL. Uthelekiso lwe-PET-CT imaging lubonisa ukuba kwii-tumor zokuqala ezingama-24 ezisasazeka emzimbeni wakhe, kusele enye kuphela. NgoMatshi walo nyaka, uNksz. K wenza utyando lwesibini ukuze athathwe iisampulu.