I-melanoma yeliso (ekuqaleni), ilandelwe zii-metastatic liver tumors-02

Ngowama-2021, uNksz Y ngequbuliso wabona into engaqhelekanga ekuboneni kweliso lakhe lasekunene. Uvavanyo olupheleleyo lwatyhila ukuba wayene-melanoma yeliso. Ngethamsanqa, yafunyanwa kwangethuba yaza yahlelwa njengenqanaba 1A, inethuba le-2% kuphela lokusasazeka kwesifo. Emva kokufumana unyango lwe-radiotherapy, wayengenaso isifo somhlaza okwethutyana, nangona ixabiso yayikukungaboni okungapheliyo kweliso elichaphazelekayo.

Nangona kunjalo, ngelishwa, ithumba labuya kunyaka olandelayo laza laqala ukukhula ngokukhawuleza. Uvavanyo lwabonisa ukuba isibindi sakhe sasisele sineethumba ezingaphezu kweshumi ezinobukhulu obahlukeneyo. Ngenxa yoko, iingcali zamcebisa ukuba athathe inxaxheba kuvavanyo lweklinikhi lwe-TIL (tumor-infiltrating lymphocyte).

Utata kaNksz Y nomyeni wakhe baqokelele iirekhodi zakhe zonyango baza baqhagamshelana noogqirha kulo lonke ilizwe ukuze bafumane uvavanyo olufanelekileyo lweklinikhi, ekugqibeleni bafumana inkqubo yethu. Le ndlela isebenzisa iiseli zomzimba zokulwa nomhlaza.

Oogqirha basusa inxalenye yethumba kwisibindi sikaNkosazana Y, baza bahlula iiseli ze-T ezibulalayo kuso, baza bandisa inani lazo ukuya kwi-10 ukuya kwi-150 yeebhiliyoni, benza umkhosi weeseli ze-clone. Lo mkhosi mkhulu weeseli emva koko wabuyiselwa emzimbeni wakhe ukuze anike uhlaselo oluchanekileyo, olunamandla, noluqhubekayo kwiiseli zomhlaza.

Ukulima iiseli zeTIL kuthathe malunga neeveki ezintathu kwaye kwafuna iseshoni yonyango enye kuphela. NgoSeptemba 2023, uNksz Y wenziwa iveki yechemotherapy, i-TIL infusion, kunye ne-IL-2. Olu nyango luqatha lubangele iziphumo ebezingalindelekanga, kubandakanya iintlungu zamalungu, uxinzelelo lokuphefumla, iimpawu zesisu, ukurhawuzelela, kunye nentloko ebuhlungu kakhulu.

Nangona kunjalo, emva kokuba ezi ziphumo bezingalindelekanga ziphelile, kwenzeka ummangaliso. Unyango lwe-TIL lubonakalise ukusebenza kakuhle kakhulu. Kungaphelanga nonyaka, phantse zonke iithumba zikaNks. Y zanyamalala okanye zancipha, kwasala enye kuphela. Ngo-2024, oogqirha basusa phantse isiqingatha sesibindi sakhe, kuquka nethumba lokugqibela. Akuba evukile, waxelelwa ukuba akukho zimpawu zesifo ezisele emzimbeni wakhe.