Ukunqoba i-Diffuse Large B-Cell Lymphoma nge-Bioocus Dual CAR-T Therapy

Isizinda Sesiguli

URodney, umuntu oqinile ovela phesheya, watholakala ene-Diffuse Large B-Cell Lymphoma (DLBCL), uhlobo olunamandla lwe-non-Hodgkin lymphoma. Eneminyaka engu-68 ubudala, wafuna izindlela zokwelapha ezithuthukisiwe ngemuva kokuba ukwelashwa okuvamile kungaphumelelanga. Ethunyelwe esikhungweni esibambisene nathi eSibhedlela Somdlavuza saseTianjin, uRodney wabhalisa kwiphrothokholi yokwelapha ye-Bioocus ye-dual CAR-T ngaphansi kwenombolo yokwelashwa P1549. Lokhu kwelashwa kuhlose kokubili ama-antigen e-CD19 kanye ne-CD20 kumaseli omdlavuza, okunikeza ukuhlaselwa okunezinhlangothi ezimbili ukuthuthukisa ukusebenza kahle nokunciphisa ingozi yokubuyela emuva.

Uhambo Lokwelapha

Ukwelashwa kukaRodney kwaqala ngoSepthemba 2025 ngokufakwa kwamaseli e-CAR-T e-autologous aklanyelwe ukuveza ama-receptor e-chimeric antigen e-CD19 kanye ne-CD20. Inqubo yayihilela ukuqoqa isampula yakhe yegazi elingaphandle (i-PB), ukuyicubungula ukuze kudalwe amaseli e-CAR-T enziwe ngokwezifiso, kanye nokufaka umthamo ofanela izidingo zakhe. Ngemva kokufakwa, intuthuko yakhe yaqashelwa eduze ngokuhlolwa kwegazi okulandelanayo ezinsukwini ezibalulekile zokulandelela: Usuku 4 (D4), Usuku 7 (D7), kanye noSuku 10 (D10).

• D4 (Septhemba 12, 2025):Ukutholwa kokuqala kubonise ukuba khona kwamaseli e-CAR-T okulinganiselwe, namaseli e-CD19+ CAR-T ku-0.50% wamaseli e-CD3+ T (inani eliphelele: 6.04 × 10^6/L) kanye namaseli e-CD20+ CAR-T ku-0.41% (inani eliphelele: 4.96 × 10^6/L). Lesi sigaba sokuqala sibonise ukufakelwa okuphumelelayo.
• D7 (Septhemba 15, 2025):Ukwanda kwasheshiswa, ngamaseli e-CD19+ CAR-T akhuphuka afinyelela ku-1.68% (inani eliphelele: 1.40 × 10^7/L) kanye namaseli e-CD20+ CAR-T afinyelela ku-1.63% (inani eliphelele: 1.36 × 10^7/L), okubonisa ukwanda okuqinile.
• D10 (Septhemba 18, 2025):Kubonwe ukwanda okukhulu kakhulu, lapho amaseli e-CD19+ CAR-T efinyelela ku-31.43% wamaseli e-CD3+ T (inani eliphelele: 3.13 × 10^8/L) kanye namaseli e-CD20+ CAR-T ku-32.74% (inani eliphelele: 3.26 × 10^8/L). Ukuhlaziywa kwesethi encane kwembule ukusatshalaliswa okulinganiselayo kuwo wonke amaseli e-CD4+ kanye ne-CD8+ T, kanye nokubalwa kwamaseli e-T ku-2.9 × 10^9/L, kufaka phakathi amaseli e-CD3+ T angu-34.35%.

Kuyo yonke inqubo yokuqapha, iphrofayili yomzimba kaRodney ibonise ushintsho oluhle, njengamaseli e-T anamandla aphezulu (i-CD3+CD8+ ku-69.56%), okuqinisekisa ikhono lokwelapha lokuvuselela amasosha omzimba wakhe ngokumelene ne-lymphoma.

Imiphumela Evelele

Ngo-D10, ukukhula okukhulu kwamaseli e-CAR-T—okungaphezu kokwanda okuphindwe ka-500 kokubala okuphelele okuvela ku-D4—kwaqokomisa umsebenzi onamandla wokulwa nomdlavuza wokwelapha. Lokhu kwanda okusheshayo kuwuphawu lokwelashwa kwe-CAR-T okuphumelelayo, okuvame ukuhambisana nokukhululwa okujulile nokuhlala isikhathi eside ezigulini ze-DLBCL. URodney wabekezelela kahle ukwelashwa, ngaphandle kwezinkinga ezinkulu ezibikiwe esigabeni sokuqapha. Icala lakhe libonisa indlela ye-Bioocus ye-CAR-T ephindwe kabili, efinyelele izinga eliphezulu lokuphendula okuphelele (CR) kanye namazinga okuphendula jikelele (ORR) kulo lonke iqembu lethu leziguli zomhlaba wonke.