Kugonjetsa Lymphoma Yaikulu ya B-Cell ndi Bioocus Dual CAR-T Therapy

Mbiri ya Odwala

Rodney, munthu wotha kupirira wochokera kunja, anapezeka ndi matenda a Diffuse Large B-Cell Lymphoma (DLBCL), mtundu woopsa wa non-Hodgkin lymphoma. Ali ndi zaka 68, anafunafuna njira zina zochiritsira zapamwamba pambuyo poti njira zochiritsira zachilendo sizinali zokwanira. Atatumizidwa ku chipatala chathu chogwirizana ku Tianjin Cancer Hospital, Rodney adalembetsa mu Bioocus's dual CAR-T therapy protocol pansi pa chithandizo nambala P1549. Chithandizochi chimayang'ana ma antigen a CD19 ndi CD20 pamaselo a khansa, zomwe zimapangitsa kuti matendawa akhale ndi mbali ziwiri kuti athandize komanso kuchepetsa chiopsezo chobwereranso.

Ulendo wa Chithandizo

Chithandizo cha Rodney chinayamba mu Seputembala 2025 ndi kulowetsedwa kwa maselo a autologous CAR-T omwe adapangidwa kuti azitha kutulutsa ma receptor a chimeric antigen a CD19 ndi CD20. Njirayi idaphatikizapo kusonkhanitsa chitsanzo cha magazi ake am'magazi (PB), kuchikonza kuti apange maselo a CAR-T omwe ali ndi makonda ake, ndikupatsa mlingo wogwirizana ndi zosowa zake. Pambuyo polowetsedwa, kupita patsogolo kwake kunayang'aniridwa mosamala kudzera mu mayeso a magazi otsatizana pamasiku ofunikira otsatira: Tsiku 4 (D4), Tsiku 7 (D7), ndi Tsiku 10 (D10).

• D4 (Seputembala 12, 2025):Kuzindikira koyamba kunawonetsa kupezeka pang'ono kwa maselo a CAR-T, ndi maselo a CD19+ CAR-T pa 0.50% ya maselo a CD3+ T (mtengo wake wonse: 6.04 × 10^6/L) ndi maselo a CD20+ CAR-T pa 0.41% (mtengo wake wonse: 4.96 × 10^6/L). Gawo loyambirira ili linasonyeza kuti kulumikizidwa kwa maselowo kunayenda bwino.
• D7 (Seputembala 15, 2025):Kufalikira kwawonjezeka, ndipo maselo a CD19+ CAR-T akukwera kufika pa 1.68% (mtengo wake wonse: 1.40 × 10^7/L) ndi maselo a CD20+ CAR-T kufika pa 1.63% (mtengo wake wonse: 1.36 × 10^7/L), zomwe zikusonyeza kuchulukana kwamphamvu.
• D10 (Seputembala 18, 2025):Kuwonjezeka kwakukulu kunawonedwa, ndi maselo a CD19+ CAR-T kufika pa 31.43% ya maselo a CD3+ T (mtengo wake wonse: 3.13 × 10^8/L) ndi maselo a CD20+ CAR-T pa 32.74% (mtengo wake wonse: 3.26 × 10^8/L). Kusanthula kwa subset kunawonetsa kugawa koyenera pakati pa maselo a CD4+ ndi CD8+ T, ndi kuchuluka kwa maselo a T pa 2.9 × 10^9/L, kuphatikiza maselo a CD3+ T 34.35%.

Pa nthawi yonse yowunikira, chitetezo cha mthupi cha Rodney chinawonetsa kusintha kwabwino, monga kuchuluka kwa maselo a T omwe ali ndi poizoni (CD3+CD8+ pa 69.56%), zomwe zikusonyeza kuti chithandizochi chingathandize chitetezo chake cha mthupi kulimbana ndi lymphoma.

Zotsatira Zabwino Kwambiri

Pofika pa D10, kukula kwakukulu kwa maselo a CAR-T—kuwonjezeka kopitilira nthawi 500 kwa chiwerengero chonse cha D4—kunawonetsa mphamvu ya mankhwala oletsa chotupa. Kukula mwachangu kumeneku ndi chizindikiro cha chithandizo cha CAR-T chopambana, nthawi zambiri chimagwirizana ndi kuchira kwakukulu komanso kolimba kwa odwala a DLBCL. Rodney anapirira bwino chithandizochi, popanda zovuta zazikulu zomwe zinanenedwa mu gawo loyang'anira. Nkhani yake ikuwonetsa njira ya Bioocus ya CAR-T iwiri, yomwe yapeza mayankho apamwamba (CR) ndi kuchuluka kwa mayankho (ORR) padziko lonse lapansi.