Chithandizo cha CAR-T cha Neuroblastoma Yobwerera M'mbuyo/Yosasinthika

Chithandizo cha GD2 CAR-TNdi njira yatsopano yochiritsira matenda yomwe imasintha majini a maselo a T a wodwala kuti azindikire ndikuukira maselo a neuroblastoma omwe akuwonetsa antigen ya GD2. Mankhwalawa adapangidwira makamaka odwala omwe ali ndi neuroblastoma yobwereranso kapena yokana ndipo yawonetsa zotsatira zabwino zachipatala m'mayesero.

• Mkhalidwe wa Matenda: Matenda a neuroblastoma omwe ali pachiwopsezo chachikulu omwe ali ndi matenda osatha, obwereranso, kapena omwe amapitirirabe pambuyo pa chithandizo choyamba.

• Zinthu ZinaMatenda a Metastatic, MYCN yowonjezera, kapena kukana mankhwala ochiritsira.

Masitepe Ofunika

1. Kukonzekera koyambiriraKuchepa kwa lymphocyte musanayambe kumwa mankhwala.

2. Kulowetsedwa: Kuyeza molondola maselo a GD2-CAR-T (koyenera: maselo a T omwe ali ndi CAR-positive 10×10^6/kg).

3. Londola: Kujambula zithunzi nthawi zonse (PET/CT, MRI) ndi kuwunika kwa mafupa pambuyo popatsidwa mankhwala.

Zotsatira Zachipatala

• Chiwerengero cha Mayankho: 33% adapeza chikhululukiro chonse (CR), ndi chiŵerengero chonse cha mayankho (CR+PR) cha 63%.

• Kupulumuka: Kupulumuka konse kwa zaka zitatu (OS) kwa 60% ndi kupulumuka kopanda zochitika (EFS) kwa 36% pa mlingo woyenera.

• Mbiri Yachitetezo: Zovuta zomwe zimafala kwambiri zinali matenda otha kuchiritsidwa a cytokine release syndrome a Giredi 1-2 (74%).

Ubwino Wathu

• Galimoto ya m'badwo wachitatu: Magawo awiri olimbikitsa thupi (CD28 + 4-1BB) amawonjezera mphamvu ya maselo a T komanso kupirira kwawo.

• Chosinthira Chotetezeka: Jini yolumikizidwa ya iC9 imalola kuwongolera mwachangu poizoni ngati pakufunika.

• Mbiri Yotsimikizika: Anawonetsa kupambana mu mayeso azachipatala ndi deta yolondola ya nthawi yayitali.