Uburyo bwo kuvura indwara ya CAR-T ku ndwara ya Neuroblastoma yasubitse/yasubitse

Ubuvuzi bwa GD2 CAR-Tni uburyo bushya bwo kuvura indwara ziterwa n’umubiri buhindura uturemangingo twa T tw’umurwayi kugira ngo tumenye kandi twibasire uturemangingo twa neuroblastoma tugaragaza antigen ya GD2. Ubu buryo bwagenewe by’umwihariko abarwayi ba neuroblastoma yasubiwemo cyangwa yasubitswe ifite ibyago byinshi kandi bwagaragaje ibisubizo byiza mu igeragezwa.

• Imiterere y'indwara: Neuroblastoma ifite ibyago byinshi hamwe n'indwara idakira, yongeye kugaruka, cyangwa indwara ikomeza kwiyongera nyuma yo kuvurwa ku rwego rwa mbere.

• Ibindi bintu: Indwara ya Metastatic, MYCN yongerewe, cyangwa kudakurikiza uburyo busanzwe bwo kuvura.

Intambwe z'ingenzi

1. Gutegura mbere y'igihe: Kugabanuka k'amaraso mu mitsi mbere yo kuyitera.

2. Guteramo: Gupima neza uturemangingo twa GD2-CAR-T (byasabwe: uturemangingo twa T twa 10×10^6 twa CAR-positive/kg).

3. Gukurikirana: Gusuzuma buri gihe (PET / CT, MRI) no gusuzuma umwongo w'amagufwa nyuma yo guterwa.

Ibisubizo by'ubuvuzi

• Igipimo cy'ibisubizo: 33% bagezeho kugabanya burundu ingaruka (CR), hamwe n'igipimo rusange cy'ingaruka (CR + PR) cya 63%.

• Kurokoka: imyaka 3 yo kubaho muri rusange (OS) ya 60% naho EFS (EFS) ya 36% ku gipimo cyagenwe.

• Umwirondoro w'umutekano: Indwara mbi zakunze kugaragara ni indwara yo mu cyiciro cya 1-2 cytokine release syndrome (74%) ishobora gukemuka.

Ibyiza byacu

• CAR yo mu gisekuru cya gatatu: Dual co-stimulatory domains (CD28 + 4-1BB) yongera imbaraga za T-cells no gukomeza.

• Umutekano w'Umutekano: Injene ya iC9 ihuriweho ituma uburozi bugenzurwa vuba iyo bibaye ngombwa.

• Amateka yemejwe: Yagaragaje ko yatsinze mu igeragezwa ry’ubuvuzi hamwe n’amakuru afatika y’ikurikirana ry’igihe kirekire.