Amakuru

Gukurikirana nyuma yo guterwa uturemangingo tw’amaraso ni ingenzi cyane ku barwayi baterwa uturemangingo tw’amaraso (HSCT). Gusuzuma buri gihe bifasha mu kumenya ibibazo nk'ubwandu, indwara ya graft-versus-host (GVHD), no kongera gusubira inyuma, bigatuma habaho ubufasha hakiri kare kandi umusaruro ukarushaho kuba mwiza.

Ubushakashatsi bushya bwerekana ko ubuvuzi bwa CAR-T bushobora kunoza imiterere y’indwara ku barwayi ba lymphoma yo mu rwego rwo hejuru ya B (HGBL), ubwoko bwa lymphoma nini ya B, ndetse no mu nzira zo kuvurwa nyuma, bigatanga icyizere gishya kuri izi ndwara zikomeye.

Inyigo yakozwe ku buryo bwo gusuzuma uburwayi bwa CAR-T hakiri kare ugereranyije n’ubuvuzi bwa nyuma ku barwayi ba lymphoma nini ya B igaragaza ko kuvurwa hakiri kare bishobora gutuma habaho ubuvuzi bwiza kandi ingaruka mbi zikaba nke, bishyigikira ikoreshwa ryayo nk’ubuvuzi bw’icyiciro cya kabiri.

Ubushakashatsi buherutse gusohoka muri Indwara ya Lancet Rheumatology bigaragaza ko uburyo bwo kuvura uturemangingo twa CAR-T bufite umutekano kandi bufite akamaro mu kuvura lymphoma n'abarwayi benshi ba myeloma bafite indwara ziterwa n'ubwiyongere bw'umubiri cyangwa indwara ziterwa n'ububyimbirwe, ibyo bikaba bitanga ibimenyetso bifatika by'uko bukoreshwa mu buryo bwagutse.

Isuzuma ryuzuye muri Amaraso igaragaza iterambere riherutse guterwa mu gusobanukirwa ubwoko bw'uturemangingo twa B-cell Acute Lymphoblastic Leukemia (B-ALL) ku bantu bakuru. Ubushakashatsi bugamije gusuzuma itandukaniro ry'ibinyabuzima, ingaruka z'ubuvuzi, n'akamaro k'ubuvuzi bunoze mu kunoza umusaruro w'abarwayi.

Igerageza ryakorewe mu Bushinwa mu byiciro byinshi ryagaragaje umutekano n'ubushobozi bwa prizlon-cel, uburyo bwo kuvura CD19/CD20 CAR-T bugizweho ingaruka ebyiri, butanga icyizere gishya ku barwayi barwaye lymphoma ya B-cell non-Hodgkin (r/r B-NHL) yasubiwemo/isubira inyuma.

Ubushakashatsi buherutse gusohoka muri Amaraso igaragaza urugero rwa BCMA (sBCMA) rushongeshwa hamwe n'ingano y'utubyimba tw'umubiri (MTV) nk'ibipimo bishobora guhanura ibisubizo by'ubuvuzi bwa CAR-T ku barwayi ba myeloma nyinshi (RRMM) basubiye inyuma kandi badashobora kuvura, bityo bigatanga inzira yo kuvura ku giti cyabo.

Ubuvuzi bwa CAR-T, bwabanje kuba intambwe ikomeye ku ndwara za kanseri zo mu bwoko bwa B-cell, burimo kugaragaza icyizere mu kuvura kanseri zo mu bwoko bwa T-cell na kanseri yo mu bwoko bwa T-cell acute lymphoblastic leukemia (T-ALL). Ubu buvuzi bugenda butera imbere buhura n'imbogamizi zidasanzwe ariko igeragezwa riherutse gukorwa mu buvuzi ritanga icyizere cy'uburyo bushya bwo kuvura kanseri zo mu bwoko bwa T-cell.

Itsinda ry’abaganga rya Lu Daopei ryageze ku ntambwe ikomeye mu kuvura kanseri y’imitsi itera kanseri y’imitsi itera kanseri (AML) binyuze mu bushakashatsi bwabo ku buvuzi bwa CD7 CAR-T bushingiye ku mubiri, bwasohotse mu kinyamakuru cy’icyamamare. Amaraso.

Iterambere riherutse gukorwa mu kuvura indwara ya Menin ritanga uburyo bwiza bwo kuvura kanseri y’imitsi itera ...