Amakuru

Ubushakashatsi bw’ingenzi bwagaragaje akamaro gakomeye k’ubuvuzi bwa CAR-T mu kuvura kanseri y’amaraso ya B-cell Acute Lymphoblastic Leukemia (B-ALL). Ubushakashatsi, bufatanyije na BIOOCUS n’ibitaro bya Lu Daopei, bwerekanye iterambere rikomeye, bugaragaza ko ubwo buvuzi ari uburyo bw’ingenzi bwo kuvura.

Abashakashatsi bo mu bitaro bya Lu Daopei n'abafatanyabikorwa mpuzamahanga basesengura uburyo bugezweho bwo kuvura uturemangingo twa CAR-T, batanga icyizere ku barwayi ba kanseri y'uturemangingo twa B. Ubu bushakashatsi bugaragaza iterambere mu miterere n'ikoreshwa ryabwo, bugaragaza umusaruro mwiza n'ubushobozi bwo guhanga udushya mu gihe kizaza.

Ubushakashatsi buherutse gukorwa ku buvuzi bwerekanye ko uturemangingo twa CD19 CAR-T dushingiye kuri 4-1BB tugaragaza ubushobozi bwo kurwanya kanseri ugereranije n’uturemangingo twa CAR-T dushingiye kuri CD28 mu kuvura kanseri y’amaraso ya B selile yasubiwemo cyangwa idashobora kuvura kanseri (r/r B-ALL).

Ubushakashatsi buherutse gukorwa mu bitaro bya Lu Daopei bwerekanye ko uburyo bwo kuvura CD19 CAR-T cells ku gipimo gito ari bwiza kandi bufite umutekano mu kuvura abarwayi ba B-ALL barwaye kanseri y’uruhu itera indwara idakira cyangwa yasubitse kurwara kanseri y’uruhu (B-ALL). Ubushakashatsi bwakozwe n’abarwayi 51 bwagaragaje ko bakize cyane kandi ko ingaruka mbi ari nke cyane.

Ibitaro bya Lu Daopei na Hebei Senlang Biotechnology batangaje ibyavuye mu bushakashatsi bwabo buherutse ku birebana n'umutekano n'akamaro k'ubuvuzi bwa CAR-T mu kuvura kanseri y'amaraso yo mu bwoko bwa B. Ubu bufatanye bugaragaza ubushobozi bw'imiterere mishya y'uturemangingo twa CAR-T mu kunoza umusaruro w'abarwayi.

Ubushakashatsi bushya bwayobowe na Dr. Zhi-tao Ying wo mu bitaro bya kaminuza ya Peking Cancer bwagaragaje umutekano n'ubushobozi bwa IM19 CAR-T selile therapy mu kuvura kanseri y'amaraso ya B selile yasubiwemo kandi idashobora kugaragara. Byasohotse mu kinyamakuru Ikinyamakuru cy'Abashinwa cy'Imiti Mishya, ubushakashatsi buvuga ko abarwayi 11 kuri 12 bakize burundu nta ngaruka mbi zikomeye bahuye nazo, bigaragaza ko ubushobozi bwa IM19 ari uburyo bwiza bwo kuvura abarwayi bafite ubundi buryo buke.

Mu myaka mirongo itanu ishize, ubushakashatsi ku turemangingo tw’umubiri twica ubudahangarwa (NK) bwahinduye imyumvire yacu ku budahangarwa bw’umubiri, butanga uburyo bushya bwiza bwo kuvura kanseri n’udukoko.

Amahugurwa ngarukamwaka ya 2024 ku bijyanye no gucunga amaraso mu buvuzi no kuyatera mu ikoranabuhanga mu Mujyi wa Sanhe yabereye neza mu bitaro bya Yanda Ludaopei. Iki gikorwa kigamije kunoza uburyo bwo kuyakoresha mu buvuzi no kuyatera mu buryo burambye binyuze mu mahugurwa yuzuye yitabiriwe n'inzobere mu by'ubuvuzi zirenga 100 ziturutse mu bigo bitandukanye by'ubuvuzi.

Ubushakashatsi bwakozwe ku bitaro bya Kaminuza ya Erlangen bwavuje neza umukobwa w’imyaka 16 wari ufite indwara ikomeye ya lupus erythematosus (SLE) hakoreshejwe uburyo bwa CAR-T cell therapy. Ubu ni bwo buryo bwa mbere bwo kuvura lupus mu bana, butanga icyizere gishya ku bana bafite indwara ziterwa n’ubwiyongere bw’umubiri.

Ubushakashatsi buherutse gukorwa muri Nature Communications bwagaragaje ibitekerezo by'ingenzi ku nzira z'ubuhanga mu gutanga ibimenyetso zihindura imikorere y'igabanuka rya poroteyine hifashishijwe PROTACs. Ubu buvumbuzi bushobora gutanga inzira yo kuvura kanseri n'izindi ndwara neza kurushaho.

Kugira ngo abarwayi ba kanseri y'amaraso bavurwe neza kandi neza, bisaba kwita ku buzima bwabo bwa buri munsi, harimo isuku ku bidukikije, isuku y'umubiri, imirire myiza, n'imyitozo ngororamubiri ikwiye. Iyi nyandiko itanga inama z'ingenzi zo kwita ku buzima bwa buri munsi mu buryo bwiza kugira ngo bakire.

Ubushakashatsi buherutse gukorwa bwerekana akamaro n'umutekano wa NS7CAR-T therapy mu kuvura kanseri y'amaraso ya T-cell acute lymphoblastic leukemia (R/R T-ALL) yasubiwemo cyangwa itarakira (R/R T-ALL) na kanseri ya T-cell lymphoblastic (R/R T-LBL). Ubu buvuzi butanga icyizere gishya ku barwayi bafite ubwo bwoko bwa kanseri bukabije.