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Kev Kho Mob CAR-T Ua Ntej Hauv B-cell Acute Lymphoblastic Leukemia Qhia Txog Kev Ua Haujlwm Zoo Tshaj Plaws
Ib txoj kev tshawb fawb tshiab qhia txog qhov ua tau zoo ntawm CAR-T cell therapy hauv kev kho mob B-cell Acute Lymphoblastic Leukemia (B-ALL). Kev tshawb fawb, uas muaj kev koom tes nrog BIOOCUS thiab Lu Daopei Hospital, qhia txog kev nce qib tseem ceeb, tsim kom muaj kev kho mob ua ib qho kev xaiv kho mob tseem ceeb.
Kev Kho Mob CAR-T Cell Tshiab Hloov Kev Kho Mob B Cell Malignancies
Cov kws tshawb fawb los ntawm Lu Daopei Tsev Kho Mob thiab cov neeg koom tes thoob ntiaj teb tshawb nrhiav cov kev kho mob CAR-T cell tshiab, muab kev cia siab rau cov neeg mob uas muaj kab mob B cell malignancies. Txoj kev tshawb fawb no qhia txog kev nce qib hauv kev tsim qauv thiab kev siv, qhia txog cov txiaj ntsig zoo thiab lub peev xwm rau kev tsim kho tshiab yav tom ntej.
Kev Ua Haujlwm Zoo Dua ntawm 4-1BB-Based CD19 CAR-T Cells hauv Kev Kho B-ALL
Cov kev tshawb fawb kho mob tsis ntev los no qhia tau tias cov hlwb CD19 CAR-T uas ua raws li 4-1BB qhia tau tias muaj txiaj ntsig zoo dua li cov hlwb CAR-T uas ua raws li CD28 hauv kev kho cov kab mob B cell uas rov qab los lossis tsis kho tau (r/r B-ALL).
Kev Kho Mob CD19 CAR-T Qis Qis ntawm Lu Daopei Tsev Kho Mob Qhia Txog Cov Txiaj Ntsig Zoo rau Cov Neeg Mob B-ALL
Tsis ntev los no, kev tshawb fawb ntawm Lu Daopei Tsev Kho Mob tau qhia txog kev siv tshuaj CD19 CAR-T cell tsawg tsawg los kho cov neeg mob uas tsis kho tau lossis rov qab mob dua los ntawm B acute lymphoblastic leukemia (B-ALL). Cov kev tshawb fawb no, uas muaj 51 tus neeg mob, tau qhia txog tus nqi zoo kawg nkaus uas tsis muaj mob dab tsi thiab muaj kev phiv tsawg heev.
Txoj Kev Txhawb Nqa Tshiab Txhim Kho Kev Nyab Xeeb thiab Kev Ua Haujlwm Zoo ntawm CAR-T Kev Kho Mob hauv Acute B Cell Leukemia
Tsev Kho Mob Lu Daopei thiab Hebei Senlang Biotechnology tau tshaj tawm cov kev tshawb pom zoo los ntawm lawv txoj kev tshawb fawb tsis ntev los no txog kev nyab xeeb thiab kev ua tau zoo ntawm kev kho mob CAR-T rau cov kab mob B cell leukemia mob hnyav. Kev koom tes no qhia txog lub peev xwm ntawm cov qauv tsim tshiab ntawm CAR-T cell los txhim kho cov txiaj ntsig ntawm tus neeg mob.
Kev Tshawb Fawb Txog Kev Tshawb Fawb Qhia Txog Kev Nyab Xeeb thiab Kev Ua Haujlwm Zoo ntawm CAR-T Therapy hauv Kev Kho Mob B-Cell Malignancies
Ib txoj kev tshawb fawb tshiab uas Dr. Zhi-tao Ying los ntawm Peking University Cancer Hospital coj tau qhia txog kev nyab xeeb thiab kev ua tau zoo ntawm IM19 CAR-T cell therapy hauv kev kho cov kab mob B-cell hematologic malignancies uas rov qab los thiab tsis kho tau. Luam tawm hauv Phau Ntawv Xov Xwm Suav Txog Cov Tshuaj Tshiab, txoj kev tshawb fawb qhia tias 11 ntawm 12 tus neeg mob tau zoo tag nrho yam tsis muaj kev phiv loj heev, qhia txog lub peev xwm ntawm IM19 ua ib txoj kev kho mob zoo rau cov neeg mob uas muaj lwm txoj kev xaiv tsawg.
Kev Txhim Kho Tshiab hauv Cov Qog Tua Neeg Ntuj (NK) Tshaj 50 Xyoo
Tau tsib xyoo dhau los no, kev tshawb fawb txog cov hlwb tua neeg ntuj (NK) tau hloov pauv peb txoj kev nkag siab txog kev tiv thaiv kab mob, muab cov kev cia siab tshiab rau kev kho mob qog noj ntshav thiab kab mob viral.
Kev Kawm Txuj Ci Txog Kev Tswj Xyuas Ntshav thiab Kev Hloov Ntshav Txhua Xyoo Muaj Nyob Rau Hauv Tsev Kho Mob Yanda Ludaopei
Xyoo 2024 Kev Kawm Txuj Ci Txog Kev Tswj Ntshav Hauv Tsev Kho Mob thiab Kev Siv Tshuab Hloov Ntshav hauv Sanhe City tau muaj nyob rau ntawm Tsev Kho Mob Yanda Ludaopei. Lub hom phiaj ntawm qhov kev tshwm sim no yog los txhim kho kev tswj ntshav hauv tsev kho mob thiab kev nyab xeeb ntawm kev hloov ntshav los ntawm kev cob qhia ntau yam uas muaj ntau tshaj 100 tus kws kho mob los ntawm ntau lub tsev kho mob koom nrog.
Kev Tshawb Fawb Tshiab hauv Kab Mob Autoimmune Rau Menyuam Yaus: CAR-T Cell Therapy Kho Tau Tus Neeg Mob Lupus
Ib txoj kev tshawb fawb thawj zaug ntawm Erlangen University Hospital tau kho tau ib tug ntxhais hnub nyoog 16 xyoo uas muaj mob hnyav hu ua systemic lupus erythematosus (SLE) siv CAR-T cell therapy. Qhov no yog thawj zaug siv txoj kev kho mob no rau cov menyuam yaus uas muaj mob lupus, thiab muab kev cia siab tshiab rau cov menyuam yaus uas muaj cov kab mob autoimmune.
Kev Txhim Kho Kev Ua Haujlwm Zoo ntawm PROTAC: Kev Tshawb Fawb Tshiab
Tsis ntev los no, kev tshawb fawb hauv Nature Communications tau qhia txog cov kev nkag siab tseem ceeb txog cov kev taw qhia intrinsic uas hloov kho qhov ua tau zoo ntawm kev rhuav tshem cov protein siv PROTACs. Qhov kev tshawb pom no tuaj yeem ua rau muaj kev kho mob zoo dua rau mob qog noj ntshav thiab lwm yam kab mob.
Kev Txhawb Kev Noj Qab Haus Huv thiab Kev Rov Zoo: Kev Saib Xyuas Txhua Hnub rau Cov Neeg Mob Leukemia
Kev ua kom muaj kev kho mob zoo thiab muaj kev nyab xeeb rau cov neeg mob leukemia yuav tsum tau saib xyuas txhua hnub, suav nrog kev tu cev ib puag ncig, kev tu cev tus kheej, kev noj zaub mov zoo, thiab kev tawm dag zog kom zoo. Phau ntawv qhia no muab cov lus qhia tseem ceeb rau kev saib xyuas txhua hnub kom zoo los txhawb kev rov zoo.
NS7CAR-T Cell Therapy Qhia Txog Kev Cog Lus Rau Kev Kho Mob R/R T-ALL/LBL
Tsis ntev los no, kev tshawb fawb qhia txog qhov ua tau zoo thiab kev nyab xeeb ntawm kev kho mob NS7CAR-T cell hauv kev kho mob T-cell acute lymphoblastic leukemia (R/R T-ALL) thiab T-cell lymphoblastic lymphoma (R/R T-LBL) uas rov qab mob dua lossis tsis kho tau. Kev kho mob no muab kev cia siab tshiab rau cov neeg mob uas muaj cov mob qog noj ntshav no.