Kev Kho Mob CAR-T Cell Tshiab Hloov Kev Kho Mob B Cell Malignancies
Hauv kev tshuaj xyuas tsis ntev los no uas tau luam tawm hauv Journal of the National Cancer Center, cov kws tshaj lij los ntawm Lu Daopei Tsev Kho Mob, coj los ntawm Dr. Peihua Lu, nrog rau cov neeg koom tes los ntawm University of Texas MD Anderson Cancer Center, tau qhia txog kev nce qib tshiab hauv kev kho mob CAR-T cell rau kev kho mob B-cell malignancies. Kev tshuaj xyuas no tham txog ntau txoj hauv kev tshiab, suav nrog kev hloov pauv ntawm CAR-T cell tsim thiab kev koom ua ke ntawm kev kho mob adoptive cell, los txhim kho kev ua haujlwm thiab kev nyab xeeb ntawm kev kho mob rau cov kab mob xws li non-Hodgkin's lymphoma (NHL) thiab acute lymphoblastic leukemia (ALL).
Cov kab mob qog nqaij hlav B-cell ua rau muaj teeb meem loj vim lawv nyiam rov qab mob dua thiab tsis kam kho cov tshuaj kho mob ib txwm muaj. Kev qhia txog cov hlwb chimeric antigen receptor (CAR) T tau hloov pauv txoj kev kho mob, muab kev cia siab tshiab rau cov neeg mob uas ntsib cov kab mob qog nqaij hlav no. Kev tshawb fawb qhia txog yuav ua li cas CAR T cell tuaj yeem tsim nrog ntau tiam neeg tsim, suav nrog cov yam ntxwv siab heev xws li bispecific receptors thiab costimulatory domains, kom tsom mus rau cov hlwb qog nqaij hlav zoo dua thiab txo qhov yuav rov qab mob dua.
Tsev Kho Mob Lu Daopei tau nyob rau pem hauv ntej ntawm kev tshawb fawb txog CAR-T cell thiab kev siv hauv kev kho mob, qhia txog kev vam meej zoo kawg nkaus hauv kev ua kom cov neeg mob rov zoo mus sij hawm ntev. Kev koom tes ntawm tsev kho mob hauv txoj haujlwm tseem ceeb no qhia txog nws txoj kev cog lus rau kev nce qib Kev Kho Mob Cancer thiab muab kev saib xyuas zoo tshaj plaws. Daim ntawv tshuaj xyuas kuj tshawb nrhiav txog lub peev xwm ntawm kev sib txuas CAR-T kev kho mob nrog lwm yam kev kho mob, xws li kev tiv thaiv kab mob thiab kev kho mob tsom mus rau tus neeg mob, los kov yeej cov txheej txheem tiv thaiv thiab txhim kho cov txiaj ntsig ntawm tus neeg mob.
Tsab ntawv tshaj tawm no yog ib qho pov thawj rau kev sib koom tes ntawm cov kws tshawb fawb thoob ntiaj teb thiab cov kws kho mob hauv kev thawb cov ciam teb ntawm kev kho mob qog noj ntshav. Cov kev tshawb pom no muab kev pom rau yav tom ntej ntawm kev kho mob qog noj ntshav, qhov twg kev kho mob tus kheej thiab kev kho tshiab tuaj yeem hloov pauv lub neej ntawm cov neeg mob uas tawm tsam B cell malignancies. Lu Daopei Tsev Kho Mob cov kev koom tes rau hauv daim teb no yog lub teeb ntawm kev cia siab, tsav tsheb txoj kev tsim cov kev kho mob qog noj ntshav uas muaj kev nyab xeeb dua thiab zoo dua.