Ka hurihia e ngā rongoā pūtau CAR-T auaha te maimoatanga o ngā mate pukupuku pūtau-B
I roto i tētahi arotake tata nei i whakaputaina ki te Journal of the National Cancer Center, i whakamāramahia e ngā tohunga o te Hōhipera o Lu Daopei, i arahina e Tākuta Peihua Lu, me ngā hoa mahi mai i te Whare Wānanga o Texas MD Anderson Cancer Center, ngā whanaketanga hou o ngā maimoatanga pūtau CAR-T mō te rongoā i ngā mate pukupuku pūtau-B. E matapakihia ana e tēnei arotake whānui ētahi huarahi auaha, tae atu ki te whanaketanga o te hoahoa pūtau CAR-T me te whakaurunga o ngā maimoatanga pūtau whāngai, hei whakapai ake i te whai huatanga me te haumaru o ngā maimoatanga mō ngā mate pēnei i te lymphoma kore-Hodgkin (NHL) me te leukemia lymphoblastic acute (ALL).
He nui ngā wero mō ngā mate pukupuku pūtau-B nā te mea ka hoki anō te mate, ka ātete hoki ki ngā maimoatanga tuku iho. Nā te whakaurunga mai o ngā pūtau-T chimeric antigen receptor (CAR) kua hurihia te ao rongoā, ā, kua tukuna he tumanako hou ki ngā tūroro e pāngia ana e ēnei mate pukupuku kaha. E whakaatu ana te rangahau me pēhea te hanga i ngā pūtau-T CAR me ngā whakatupuranga maha o te hoahoa, me te whakauru i ngā āhuatanga matatau pērā i ngā kaiwhakawhiwhi bispecific me ngā rohe costimulatory, kia pai ake ai te aro atu ki ngā pūtau pukupuku me te whakaiti i te tūponotanga o te hoki anō.
Kei mua tonu te Hōhipera o Lu Daopei i te rangahau pūtau CAR-T me te tono haumanu, e whakaatu ana i te angitu whakamiharo ki te whakaoho i ngā murunga roa. Ko te whai wāhi a te hōhipera ki tēnei mahi paionia e whakaatu ana i tana whakapau kaha ki te whakatairanga Te Maimoatanga Matepukupuku me te whakarato i te tiaki hou. Ka tūhuratia hoki e te arotake te kaha o te whakakotahi i ngā maimoatanga CAR-T me ētahi atu maimoatanga, pērā i te immunotherapy me ngā maimoatanga kua arotahihia, hei wikitoria i ngā tikanga ātete me te whakapai ake i ngā putanga o ngā tūroro.
He tohu tēnei pukapuka i ngā mahi tahi a ngā kairangahau me ngā tākuta o te ao ki te pana i ngā rohe o te maimoatanga mate pukupuku. Mā ngā kitenga ka kitea te heke mai o te oncology tika, ka taea e ngā maimoatanga whaiaro me te auaha te whakarerekē i te oranga o ngā tūroro e whawhai ana ki ngā mate pukupuku pūtau-B. Ko ngā takoha a te Hōhipera o Lu Daopei ki tēnei mara he tohu o te tumanako, e akiaki ana i te whanaketanga o ngā maimoatanga mate pukupuku haumaru ake, whai hua ake hoki.