Ngā Tohu Koiora Hou e Matapae ana i ngā Putanga Whakaora CAR-T i roto i te Maimoatanga Myeloma Maha

Kua puta ake te rongoā pūtau CAR-T hei maimoatanga hou mō te mate pūkahukahu me te uaua ki te aro. Myeloma maha (RRMM), e tuku ana i te tumanako ki ngā tūroro he iti noa ngā kōwhiringa maimoatanga. Heoi, he wero tonu te arotau i ngā rautaki maimoatanga i te mea kei te puta tonu mai ngā maimoatanga hou, pērā i ngā paturopi takirua. He mea nui te tautuhi i ngā tohu koiora ka taea te matapae i te whai huatanga o te rongoā CAR-T mō te whakarite maimoatanga me te whakapai ake i ngā putanga o ngā tūroro.

I whakahaerehia tētahi rangahau tata nei e ngā kairangahau mai i te Moffitt Cancer Center, ā, i whakaputaina ki roto i Toto i tūhuratia te uara matapae o ngā taumata o te antigen maturation pūtau-B soluble (sBCMA) me te rahinga pukupuku metabolic (MTV) i roto i ngā tūroro RRMM e whiwhi ana i te rongoā CAR-T. I whakaurua ki te rangahau whakamuri 183 ngā tūroro i whiwhi i te iti rawa e whā ngā raina maimoatanga o mua, ā, he raraunga kei a rātou mō ngā taumata sBCMA i mua i te maimoatanga (i mua i te chemotherapy lymphodepletion) me/ranei MTV (mā te PET-CT). I kitea e te rangahau ko te reiti oranga whānui mō te tau kotahi mō ēnei tūroro he 78%.

I whakaatuhia e te rangahau he hononga ngā taumata tiketike o te sBCMA i mua i te maimoatanga ki ētahi atu tohu taumaha pukupuku (pēnei i ngā pūtau plasma hinu wheua, β2-microglobulin) me te mumura (pēnei i te ferritin). He mea nui, he rerekē ngā taumata sBCMA i waenga i ngā kaiwhakautu me ngā kāore i whakautu, me ngā taumata teitei ake i kitea i roto i ngā tūroro uaua tuatahi. I kitea he taumata sBCMA o te 97.1 ng/mL hei tohu i te pikinga o te paitini e pā ana ki te rongoā CAR-T me te kino ake o te oranga kore-haere whakamua (PFS).

I tua atu, ko te MTV teitei, me te tapahi o te 6.3 mL, i honoa ki te PFS poto ake me te oranga whānui ngoikore (OS). Heoi, he ngoikore te hononga i waenga i te sBCMA me te MTV, e kī ana ko te tātaritanga ngātahi o ngā tohu koiora e rua ka āwhina pea ki te aromatawai i ngā tūroro me ngā hua koretake. Hei tauira, ko ngā tūroro he iti te sBCMA me te iti o te MTV i whakaatu i te matapae pai rawa atu, ko te hunga he iti te sBCMA me te nui o te MTV i nui ake te mōrearea o te korenga o te maimoatanga nā te iti o te BCMA, te BCMA-kino rānei o ngā pūtau plasma.

E whakanui ana te rangahau i te kaha o te sBCMA me te MTV hei tohu koiora mō te whakawhaiaro i te rongoā CAR-T i roto i te RRMM, kia pai ake ai te whakahaere i ngā tūroro e hiahia ana ki ngā maimoatanga e arohia ana ki te BCMA. He mea nui, ko te haurua-ora o te sBCMA (24-36 hāora) he poto ake i ētahi atu tohu taumaha pukupuku, pērā i te IgG, IgA, me ngā mekameka mārama κ/λ, ā, he tohu tere ake, he tohu pono ake hoki mō te aromatawai i ngā pānga maimoatanga me te taumaha pukupuku toenga.

E matapaetia ana ka whai wāhi nui ēnei kitenga ki te whakapai ake i ngā rautaki whakaora CAR-T me te whakapai ake i ngā putanga mō ngā tūroro RRMM, me te whakaatu i te hiranga o ngā huarahi maimoatanga whaiaro, e arahina ana e ngā tohu koiora.