He urupare wawe whakamiharo tā te tūroro o Ahitereiria mā te rongoā CD19/CD20 CAR-T takirua a te BIOOCUS Medical Group mō te DLBCL kua hoki whakamuri.

I kitea he mate pukupuku nui horapa a Rodney Charles Monger, he tāne 68-tau te pakeke nō Ahitereiria. Lymphoma Pūtau-B (DLBCL) e toru tau ki muri. I tana rapunga i te tiaki matatau, ka tahuri ia ki te BIOOCUS Medical Group i te marama o Ākuhata 2025. I whakaūtia e te koiora o te kōpū lymph o te kaki te lymphoma pūtau-B whakaeke mai i te pokapū germinal. He tino pai te immunohistochemistry mō te CD20, CD19, me te CD10, me te nui o te whakaaturanga o Bcl-6, Bcl-2 (70%+), me te c-MYC (60%+). I whakaatuhia e te whakamātautau ira te whakaritenga anō o te BCL2 e FISH me ngā whakarerekētanga ira i roto i ngā ira EZH2, KMT2D, TNFRSF14, NRAS, me te TPMT—he tohu mārama o te kōtaha kaha, mōrearea nui.

I muri i te whiwhinga o te pola i honoa ki te aukati BTK me te lenalidomide, ā, i muri mai ko te chemotherapy lymphodepletion FC, i noho pakari tonu te mate a Mr. Monger. I tūtohu te tīma i BIOOCUS Medical Group i tā rātou rongoā auaha mō ngā pūtau CD19/CD20 CAR-T arotahi-rua.

I te 8 o Hepetema, 2025, i whiwhi a Mr. Monger i te werohanga o ngā pūtau CD19/CD20 CAR-T autologous. He mea whakamiharo, kāore ia i pāngia e te cytokine release syndrome (CRS) me te immunotoxicity syndrome (ICANS), ā, i hua ake he maeneene te tukanga i muri i te werohanga, ā, i noho pūmau, i hihiri hoki ia mai i te rā tuatahi.

I roto i te aroturuki toto ā-taha, i kitea te whānui whakamiharo o ngā pūtau CAR-T, ā, i whakaū i te pai o te whakaurunga me te tipu. I te rā 4 i muri i te werohanga, ko ngā pūtau CAR19+ he 0.50% o ngā pūtau CD3+ T (uara tino 6.04 × 10⁷/L) me ngā pūtau CAR20+ he 0.41% (4.96 × 10⁷/L). I te rā 7, i piki ake te CAR19+ ki te 1.68% (1.40 × 10⁷/L) me te CAR20+ ki te 1.63% (1.36 × 10⁷/L). I te rā 10, i eke te CAR19+ ki te 31.43% o ngā pūtau CD3+ T (uara tino 3.13 × 10⁸/L) ā, i eke te CAR20+ ki te 32.74% (uara tino 3.26 × 10⁸/L). I whakaatuhia anō e te flow cytometry te tohatoha taurite puta noa i ngā huinga CD4+ me CD8+ me te kaha o te whakaaturanga CAR takirua, e whakaatu ana i te kaha o te rongoā ki te whakatairanga i te pumau me te tipu kaha i roto i te ora tonu.

I te arotakenga hou (rā 10), kei te pai tonu te āhua o Mr. Monger i roto i te rongoā. Kei te tango ia i ngā rongoā ā-waha kua whakaritea mōna, tae atu ki te acyclovir, te sulfamethoxazole matū, te orelabrutinib, te lenalidomide, me ngā rongoā tautoko, me te aroturuki tonu i ngā tatauranga toto, te mahi ate me te whatukuhu, me ngā tohu mumura.

I whakarato te tīma Rōpū Hauora BIOOCUS i te tautoko whānui, arotahi ki te tūroro puta noa, tae atu ki te wāhi noho whakamarie, ngā kai totika, te āwhina kawe waka, me te tohutohu hinengaro mō Mr. Monger me tōna whānau. Nā tēnei huarahi whānui i taea ai e ia te aro katoa ki te whakaora.

Ko te take a Mr. Monger e whakaatu ana i te kaha whakarerekētanga o te rongoā CD19/CD20 CAR-T takirua a BIOOCUS Medical Group mō ngā tūroro he DLBCL kua hoki whakamuri/he uaua ki te rongoā. Ko te tere me te kaha o te horapa o ngā pūtau CAR-T me te kore he paitini nui e whakaatu ana i te āhua haumaru pai o te hua me te kaha ārai-pukupuku - ahakoa i roto i te tūroro pakeke ake he nui ngā āhuatanga ngota morearea.