He Rangahau Hou e Whakaū ana i te Haumaru me te Whai Huatanga o te Whakaora CD19/CD20 CAR-T mō te r/r B-NHL

He rangahau hou i whakaputaina i roto i Totoe whakaatu ana i te angitu o te whanaketanga o te prizloncabtagene autoloucel (prizlon-cel), he rongoā hou mō ngā pūtau CAR-T e aro ana ki te CD19/CD20, hei rongoā i ngā pūtau-B kua hoki whakamuri/uaua hoki. Lymphoma Kore-Hodgkin (r/r B-NHL). Ko te whakamātautau, he rangahau tuwhera-tapanga wāhanga 1, maha-pokapū, i whakahaerehia i Haina, e tuku ana i ngā raraunga whai hua mō te haumaru me te whai huatanga o tēnei huarahi arotahi-rua.

I raro i te arataki a tētahi rōpū kairangahau rongonui mai i ngā whare wānanga tae atu ki te Hōhipera Hononga Tuatahi o Te Whare Wānanga o Zhejiang me Te Whare Wānanga o Tongji, i whakaurua e te rangahau he 48 ngā tūroro me te r/r B-NHL, ko te nuinga he nui Lymphoma Pūtau-B (LBCL). I mua, kua toru ngā momo rongoā kua tukuna ki ngā tūroro. I whiwhi ngā kaiuru i te werohanga kotahi o te prizlon-cel i muri i te rongoā lymphodepleting, me ngā horopeta e toru ngā taumata (DL1, DL2, me te DL3).

Ngā Kitenga Matua:

• Kōtaha Haumaru: Kāore i kitea he paitini whakawhāiti horopeta (DLT), ā, i whakaatuhia e te rongoā he pānga taha ka taea te whakahaere. I puta te mate tukunga cytokine (CRS) i roto i te 93.8% o ngā tūroro, ko te nuinga he reanga 1–2, me te kotahi anake te reanga 3. He onge, he ngawari hoki te mate paitini io e pā ana ki ngā pūtau ārai mate (ICANS), kāore he pānga reanga 3, neke atu rānei.
• Whai huatanga: I tutuki te reiti urupare whānui (ORR) o te 91.5%, me te reiti urupare katoa (CR) o te 85.1%. I roto i ngā tūroro LBCL, ko ngā reiti ORR me te CR he 90.7% me te 86.0%, ia. He mea whakamiharo, 48.9% o ngā tūroro i mau tonu te CR i te arotakenga whakamutunga, me ētahi urupare neke atu i te toru tau.
• Ngā Hua Ora: I whakaatuhia e ngā whakatau tata a Kaplan-Meier ko te roanga o te urupare (DOR) mō ngā tau e rua, te oranga kore-haere whakamua (PFS), me ngā reiti oranga whānui (OS) he 66.0%, 62.6%, me te 76.5%, ia. Mō ngā tūroro CR, he teitei ake ēnei reiti.

I whakaatu a Prizlon-cel i te kaha o te horapa me te pumau mō te wā roa, me te wā whakaora pūtau-B toharite o te 185 rā. Ko tana hoahoa takirua-aronga e aro ana ki te mawhiti o te antigen, he tikanga ātete noa i roto i ngā maimoatanga CAR-T.