He Hua Pai te Whakaora CD19/BCMA CAR-T Takirua a BIOOCUS Medical Group mō te Myasthenia Gravis Ātete: Te Haerenga a te Tūroro Taiohi

Ko te Myasthenia Gravis (MG) he mate pūkahukahu mau tonu e puta mai ana i ngā autoantibodies (ko ngā anti-acetylcholine receptor antibodies te nuinga, AchRAb) e whakararu ana i te hononga io-uaua, ka puta te ngoikore haere, te ptosis, te dysphagia, ā, i ngā wā kino ka mate pea te korenga o te manawa. Mō ngā tūroro he MG uaua-kore e aro ana ki te rongoā ārai mate, ki te IVIG, ki ngā aukati FcRn, ki ngā aukati tāpiringa rānei, he iti noa ngā kōwhiringa maimoatanga—tae noa ki tēnei wā.

Ko te rongoā takirua-whainga CD19/BCMA CAR-T a BIOOCUS Medical Group he rongoā pūtau-aunoa hou e whakakore tika ana i ngā pūtau-B pathogenic me ngā pūtau plasma e kawenga ana mō te hanga autoantibody. Mā tēnei huarahi takirua-whainga ka taea te murunga hohonu me te roa mā te aro atu ki ngā wāhanga pūtau me te humoral o te urupare ārai-aunoa.

E whakaatu ana tētahi tauira matua i te oati o te rongoā. I kitea he mate Myasthenia Gravis (CNGIIIa, AchRAb-positive) i tētahi tūroro wahine 20-tau te pakeke, e kiia nei ko LYN, me te mate Myasthenia Gravis uaua (CNGIIIa, AchRAb-positive) me te mate thymoma/thymic hyperplasia momo-B3 i muri i te pokanga. I pāngia anō hoki ia e ngā mate tāpiri tae atu ki te osteoporosis, te mate necrosis avascular o te pane femur rua me te mate necrosis avascular tibial proximal maui, me te anemia ngoikore-rino. Ahakoa ngā momo rongoā maha mai i te tau 2019 ki te 2025—tae atu ki ngā steroids horopeta teitei me te azathioprine, tacrolimus, cyclosporine, IVIG anō, efgartigimod, eculizumab me te telitacicept, me te rituximab (500 mg)—i noho tonu tōna āhua kāore i te taea te whakahaere.

I te Whiringa-ā-rangi 2025, i tīmatahia te tikanga CAR-T, ā, i whakamutua te cyclosporine. I kohia ngā pūtau toto mononuclear ā-rohe i te 1 o Hakihea, 2025. I te 15 o Hakihea, 2025, i werohia ia ki te CD19 CAR-T (0.5×10⁶/kg) me te BCMA CAR-T (1×10⁶/kg). Kāore i kitea he pānga kino i muri i te werohanga.

I te marama o Poutū-te-rangi 2026, i whakaatuhia e ngā aromatawai whai muri te tere o te horapa o te CAR-T in-vivo, me te tihi o te CD19 CAR-T i te rā 10 (7.62%, 4.622×10⁷/L) me te BCMA CAR-T i te rā 10 (17.17%, 1.0414×10⁸/L), i mau tonu tae noa ki te marama 3. Ko ngā whakapainga taiwhanga i uru atu ki te whakahekenga nui o ngā taumata AchRAb me te tapeke o ngā tau toto-B, me te pumau o ngā tau toto, te mahi ate me te whatukuhu. I roto i te haumanu, i tuhia ngā pikinga nui i roto i ngā kaute Quantitative Myasthenia Gravis (QMG) me ngā kaute Activities of Daily Living (ADL). Ko ngā tohu pēnei i te diplopia, te pakari o te kanohi, te dysarthria, me te ngenge o ngā peka i whakaatu i te whakaoranga, i te whakapainga nui rānei.

E whakaatu ana tēnei kēhi i te kaha whakarerekētanga o te rongoā CD19/BCMA CAR-T whainga-rua a BIOOCUS Medical Group ki te whakatutuki i te tautuhi anō i te ārai mate me te painga haumanu nui i roto i te MG uaua. He pai te manawanui ki te rongoā, kāore he CRS, he paitini roro rānei i kitea, ā, he oati mō te murunga mō te wā roa me te whakaiti i te hiahia mō te pehitanga ārai mate mau tonu.