Ngā Pūrongo Ahumahi
Ka wikitoria te rongoā CAR-T i te matapae kino i roto i te Lymphoma pūtau-B taumata teitei
E whakaatu ana tētahi rangahau hou ka taea e te rongoā CAR-T te whakapai ake i te putanga mō ngā tūroro e pangia ana e te lymphoma pūtau-B teitei (HGBL), he momo lymphoma pūtau-B nui, ahakoa i roto i ngā momo maimoatanga o muri mai, e tuku ana i te tumanako hou mō ēnei take uaua.
Te Whakahaere i ngā Āhuatanga Roa o te Whakaora CAR-T: Ngā Tirohanga mai i te Taiao Mate Pukupuku
He rangahau hou i whakaputaina i roto i Matepukupuku Taiao e whakaatu ana i ngā raruraru roa o te rongoā pūtau CAR-T, e arotahi ana ki ngā mōrearea o ngā mate urutā me ngā mate pukupuku tuarua, ā, e tuku ana i ngā rautaki hei whakapai ake i ngā putanga mō ngā tūroro.
Te wikitoria i ngā wero i roto i te rongoā CAR-T mō ngā matepukupuku toto pūtau-T
Ahakoa kua hurihia e te rongoā CAR-T te rongoā mō ngā mate pukupuku pūtau-B, kei te mau tonu ngā wero nui i roto i te rongoā i ngā mate pukupuku pūtau-T. E tūhuratia ana i roto i tētahi arotake tata nei ngā uauatanga o te rongoā CAR-T i roto i ngā mate pukupuku toto pūtau-T me ngā otinga pea hei whakakore i ēnei arai.
Te Mārama ki te Thalassemia: He Aratohu Whānui ki ngā Āhua Alpha me Beta
He maha ngā mate o te thalassemia. E tūhuratia ana i roto i tēnei aratohu te alpha me te beta thalassemia, ō rāua take, ō rāua tohu, me ngā kōwhiringa maimoatanga hou e wātea ana i te BIOOCUS International Medical Center.
He whakapainga nui te whakaora pūtau NK me te kano ārai mate DC i roto i te mate pukupuku ate i te wāhanga mutunga
Kua puta he whanaketanga hou i roto i te rongoā i te mate pukupuku ate kua pāngia e te mate pukupuku ate kua horapa haere mā te whakakotahitanga o te rongoā pūtau NK, te kano kano DC, me te Nivolumab. I whakaatu tēnei whakakotahitanga o te rongoā ārai mate i te angitu whakamiharo, ā, i hua ake ai te whakaiti nui i te pukupuku me te whakapai ake i te mahi ate i roto noa i ngā wiki e ono mō tētahi tūroro e pangia ana e te mate pukupuku ate kua tata te mutunga.
He Huarahi Hou te Whakaora i te Mate Pūtau Hāri me te Thalassemia nā te Whakaora Ira Hou
I roto i tētahi kēhi haumanu hou, i angitu te wikitoria o tētahi tūroro 21-tau te pakeke i ngā wero o te thalassemia mā te whakamahi i tētahi rongoā ira matatau e hangai ana ki te CRISPR. He tohu nui tēnei huarahi auaha i roto i te rongoā i ngā mate toto kino pērā i te mate pūtau toto marino (SCD) me te thalassemia.
Te Whakahaere i ngā Pānga Taha o te Whakaora Pūtau CAR-T: Ngā Māramatanga Matua mai i ngā Rangahau Tata Nei
E whakaatu ana tēnei tuhinga pūrongo i ngā rangahau hou mō te whakahaere i ngā paitini o te rongoā pūtau CAR-T mō ngā lymphoma pūtau-B. E aro nui ana te rangahau ki ngā rautaki hei whakahaere i ngā pānga taha noa pēnei i te cytokine release syndrome (CRS) me te neurotoxicity (ICANS), kia pai ake ai te whakamahinga o tēnei rongoā hou.
Te Whai Huatanga Roa o te Whakaora Pūtau-T CD19 CAR ki te Maimoa i te Leukemia Lymphoblastic Whakapeka/Whakakeke
E whakaatu ana tētahi rangahau hou i te angitu roa o te rongoā pūtau-T CD19 CAR i roto i te rongoā i ngā tūroro e pāngia ana e te mate pukupuku toto lymphoblastic acute (ALL) whai muri i te whakawhitinga pūtau take hematopoietic allogeneic, ā, he tumanako hou tēnei i roto i te hematology.
Ngā Whakatairanga Hou i roto i ngā Pūtau Kaikōhuru Taiao (NK) Neke atu i te 50 Tau
I roto i ngā tekau tau e rima kua pahure ake nei, kua hurihia e ngā rangahau mō ngā pūtau Kaikōhuru Taiao (NK) tō tātou māramatanga ki te ārai mate ā-roto, ā, kua tukuna mai he huarahi hou hei whakatairanga mō te mate pukupuku me te whakaora huaketo.
He Huarahi Hou i roto i te Mate Pūnaha Ārai Mate o ngā Tamariki: Ka Whakaora te Maimoatanga Pūtau CAR-T i te Tūroro Lupus
I angitu te rongoā a tētahi rangahau matua i te Hōhipera o te Whare Wānanga o Erlangen i tētahi kōtiro 16-tau te pakeke he mate lupus erythematosus (SLE) kino mā te whakamahi i te rongoā pūtau CAR-T. Koinei te whakamahinga tuatahi o tēnei rongoā mō te lupus tamariki, e tuku ana i te tumanako hou mō ngā tamariki he mate pūnaha ārai mate.
Te Whakapai Ake i te Whai Huatanga o PROTAC: He Rangahau Hou
E whakaatu ana tētahi rangahau hou i roto i te Nature Communications i ngā māramatanga matua ki ngā ara tohu ā-roto e whakarerekē ana i te whai huatanga o te whakapōrearea pūmua kua arotahihia mā te whakamahi i ngā PROTAC. Mā tēnei kitenga ka taea te whakatakoto huarahi mō ngā maimoatanga whai hua ake mō te mate pukupuku me ētahi atu mate.
Te Whakatairanga i te Hauora me te Whakaora: Te Tiaki i ia Rā mō ngā Tūroro Leukemia
Ko te whakarite i tētahi wheako maimoatanga haumaru, whakamarie hoki mō ngā tūroro leukemia me whai wāhi ki te tiaki i ia rā, tae atu ki te akuaku taiao, te akuaku whaiaro, te kai totika, me te whakakori tinana tika. Kei roto i tēnei aratohu ngā tohutohu nui mō te tiaki whai hua o ia rā hei tautoko i te whakaora.