Iindaba zeShishini
Unyango lwe-CAR-T Loyisa Ukuqikelela Okubi kwi-B-Cell Lymphoma ePhakamileyo
Uphononongo olutsha lubonisa ukuba unyango lwe-CAR-T lunokuphucula ukubikezela kwangaphambili kwesifo kwizigulane ezine-B-cell lymphoma (HGBL) ekumgangatho ophezulu, uhlobo lwe-B-cell lymphoma enkulu, kwanakwimigca yonyango lwamva nje, nto leyo enika ithemba elitsha kwezi meko zinzima.
Ukulawula Iingxaki Zexesha Elide Zonyango lweCAR-T: Ingcaciso Evela Kumhlaza Wendalo
Uphononongo lwakutshanje olupapashwe kwi Umhlaza wendalo igxininisa iingxaki zexesha elide zonyango lweeseli zeCAR-T, igxile kwimingcipheko yosulelo kunye nezifo zesibini zomhlaza, kwaye inika amaqhinga okuphucula iziphumo zesigulana.
Ukoyisa Imingeni kwi-CAR-T Therapy ye-T-Cell Blood Cancers
Nangona unyango lwe-CAR-T lutshintshe unyango lomhlaza weeseli ze-B, imingeni ebalulekileyo isekhona ekunyangeni umhlaza weeseli ze-T. Uphononongo lwakutshanje luhlola ubunzima bonyango lwe-CAR-T kumhlaza wegazi weeseli ze-T kunye nezisombululo ezinokubakho zokoyisa le miqobo.
Ukuqonda iThalassemia: Isikhokelo esipheleleyo kwiifom zeAlfa kunye neBeta
I-Thalassemia sisifo esingaphezulu kwesinye. Esi sikhokelo sihlola zombini i-alpha kunye ne-beta thalassemia, izizathu zazo, iimpawu, kunye neendlela zonyango zamva nje ezifumaneka kwi-BIOOCUS International Medical Center.
Unyango lweSeli ye-NK oludityaniswe ne-DC Vaccine lubonisa ukuphucuka okukhulu kumhlaza wesibindi okwinqanaba lokugqibela
Impumelelo enkulu kunyango lomhlaza wesibindi ophucukileyo ivele ngokudibanisa okutsha kwe-NK cell therapy, i-DC vaccine, kunye ne-Nivolumab. Olu nyango oludibeneyo lwe-immunotherapy lubonise impumelelo emangalisayo, nto leyo ekhokelele ekunciphiseni okukhulu kwethumba kunye nokuphucula ukusebenza kwesibindi kwiiveki ezintandathu kuphela kwisigulana esine-hepatocellular carcinoma esekwinqanaba lokugqibela.
Unyango olutsha lwe-Gene lufezekisa impumelelo ekunyangeni isifo se-Sickle Cell kunye ne-Thalassemia
Kwimeko yeklinikhi evunyiweyo, isigulane esineminyaka engama-21 ubudala soyise ngempumelelo imingeni ye-thalassemia ngokusebenzisa unyango lwe-gene olusekelwe kwi-CRISPR. Le ndlela intsha iphawula inqanaba elibalulekileyo kunyango lweengxaki zegazi ezinzima ezifana nesifo se-sickle cell (SCD) kunye ne-thalassemia.
Ukulawula Iziphumo Ezingalindelekanga Zonyango Lweeseli ZeCAR-T: Iingcamango Eziphambili Ezivela Kuphando Lwakutshanje
Eli nqaku leendaba ligxininisa uphando lwakutshanje malunga nokulawula ubuthi be-CAR-T cell therapy kwi-B-cell lymphomas. Olu phononongo lugxininisa amaqhinga okujongana neziphumo ebezingalindelekanga ezifana ne-cytokine release syndrome (CRS) kunye ne-neurotoxicity (ICANS), ukuqinisekisa ukusetyenziswa okukhuselekileyo kolu nyango luphambili.
Ukusebenza kwexesha elide koNyango lwe-CD19 CAR T-Cell ekunyangeni i-Relapsed/Refractory Acute Lymphoblastic Leukemia
Uphononongo oluphambili lubonisa impumelelo yexesha elide yonyango lwe-CD19 CAR T-cell ekunyangeni izigulana ezine-relapse/refractory acute lymphoblastic leukemia (ALL) emva kokufakelwa kweeseli ze-hematopoietic stem, nto leyo enika ithemba elitsha kwi-hematology.
Inkqubela phambili kwiNatural Killer (NK) Cells Kwiminyaka engaphezu kwama-50
Kwiminyaka engamashumi amahlanu edlulileyo, uphando ngeeseli zeNatural Killer (NK) luye lwaguqula indlela esiqonda ngayo ukuzikhusela komzimba, nto leyo esinika iindlela ezintsha ezithembisayo zonyango lomhlaza kunye nentsholongwane.
Uphuhliso kwiSifo se-Autoimmune sabantwana: Unyango lweeSeli ze-CAR-T luphilisa iSigulana seLupus
Uphononongo oluphambili kwiSibhedlele saseYunivesithi yase-Erlangen lwanyanga ngempumelelo intombazana eneminyaka eli-16 ubudala ene-systemic lupus erythematosus (SLE) enzima kusetyenziswa unyango lweeseli ze-CAR-T. Oku kuphawula ukusetyenziswa kokuqala kolu nyango lwe-lupus yabantwana, okunika ithemba elitsha kubantwana abanezifo zokuzikhusela komzimba.
Ukuphucula ukusebenza kakuhle kwePROTAC: Uphononongo oluQhubayo
Uphononongo lwakutshanje kwi-Nature Communications lutyhila ulwazi oluphambili malunga neendlela zokubonisa ezingaphakathi ezilawula ukusebenza kakuhle kokuwohloka kweeproteni ezijoliswe kuzo kusetyenziswa ii-PROTACs. Olu fumaniso lunokuvula indlela yonyango olusebenzayo ngakumbi lomhlaza nezinye izifo.
Ukukhuthaza Impilo Nokuchacha: Ukhathalelo Lwemihla Ngemihla Lwezigulane EzineLeukemia
Ukuqinisekisa amava onyango olukhuselekileyo nolukhululekileyo kwizigulane ezine-leukemia kubandakanya ukhathalelo olucokisekileyo lwemihla ngemihla, kubandakanya ucoceko lokusingqongileyo, ucoceko lomntu, ukutya okunempilo, kunye nokuzilolonga okufanelekileyo. Esi sikhokelo sinika iingcebiso ezibalulekileyo zokhathalelo olusebenzayo lwemihla ngemihla ukuxhasa ukuchacha.