Ukulawula Iziphumo Ezingalindelekanga Zonyango Lweeseli ZeCAR-T: Iingcamango Eziphambili Ezivela Kuphando Lwakutshanje
Uphononongo lwakutshanje olupapashwe kwi I-Hematological Oncologyicacisa ngolawulo lwezinto ezinobungozi ezinxulumene nonyango lweeseli ze-T zeChimeric Antigen Receptor (CAR), unyango oluguqula izinto I-B-Cell LymphomaNangona unyango lwe-CAR-T lubonise impumelelo ephawulekayo ekunyangeni i-relapse okanye i-refractory large B-cell lymphoma, lukwazisa nemingeni ebalulekileyo ngenxa yeziphumo ebezingalindelekanga ezinzulu.
Olu phononongo, olukhokelwa nguGqr. S. Neelapu, lugxile kwizinto ezimbini ezinobungozi ezibonwa ngonyango lwe-CAR-T: i-cytokine release syndrome (CRS) kunye ne-immune effector cell-associated neurotoxicity syndrome (ICANS). Ezi zinto zinobungozi zihlala zenzeka emva nje kokufakwa kwe-CAR-T kwaye zifuna ulawulo olukhawulezileyo ukuthintela iingxaki ezinzima. I-CRS idla ngokubonisa umkhuhlane, uxinzelelo lwegazi oluphantsi, kunye nobunzima bokuphefumla, ngelixa i-ICANS inokukhokelela ekudidekeni, ekuxhuzuleni, kwaye kwiimeko ezinzima, kwi-coma.
Eli nqaku ligxininisa ukubaluleka kokuchongwa kwangethuba kunye nokubekwa ngokwamanqanaba kwezi zinto zinobungozi ukuze kulungiselelwe amaqhinga afanelekileyo okunyanga. Likwaxoxa ngokusetyenziswa kwezonyango ezifana ne-tocilizumab ye-CRS kunye ne-corticosteroids ye-ICANS, eziye zabonakala zisebenza ekunciphiseni ezi mpendulo zinokuba yingozi ebomini.
Ngaphezu koko, le ngxelo ihlola izinto ezinobungozi ezihlala ixesha elide, kuquka i-cytopenia ende (ukwehla kwenani leeseli zegazi) kunye nemiphumo ejoliswe kuyo, engeyoye-tumor, efuna ukujongwa nokulawulwa okuqhubekayo. Olu phononongo lugxininisa ukuba, nangona unyango lwe-CAR-T lunamandla amakhulu, ababoneleli beenkonzo zempilo kufuneka baxhotyiswe ukuze bajongane nemiphumo yalo eyahlukileyo neyingozi.
Ngezilingo zeklinikhi eziqhubekayo kunye nezinto ezintsha, eli candelo liyaqhubeka nokuphuhlisa amaqhinga angcono okulawula ezi zinto zinobungozi, okuvumela unyango lwe-CAR-T ukuba lusetyenziswe ngokukhuselekileyo nangokufanelekileyo.