Ho Laola Litla-morao tsa Kalafo ea Lisele tsa CAR-T: Lintlha tsa Bohlokoa tse tsoang Lipatlisisong tsa Haufinyane
Phuputso ea morao tjena e phatlalalitsoeng ho Oncology ea Hematologicale fana ka leseli mabapi le taolo ea chefo e amanang le phekolo ea lisele tsa T tsa Chimeric Antigen Receptor (CAR), e leng phekolo e ncha bakeng sa Lymphoma ea Lisele tsa Bs. Leha phekolo ea CAR-T e bontšitse katleho e ikhethang ho phekoleng lymphoma e kholo ea B-cell e khutlileng kapa e sa laoleheng, e boetse e tlisa liphephetso tse kholo ka lebaka la litla-morao tse tebileng.
Phuputso ena, e etelletsoeng pele ke Ngaka S. Neelapu, e shebana le chefo e 'meli e tloaelehileng haholo e bonoang ka phekolo ea CAR-T: cytokine release syndrome (CRS) le immune effector cell-associated neurotoxicity syndrome (ICANS). Chefo ena hangata e hlaha kapele ka mor'a ho kenngoa ha CAR-T 'me e hloka taolo ea hang-hang ho thibela mathata a tebileng. CRS hangata e hlahisa feberu, khatello e tlase ea mali le mathata a ho hema, ha ICANS e ka lebisa pherekanong, ho tšoaroa ke sethoathoa, 'me maemong a boima, ho ba le koma.
Sengoloa sena se totobatsa bohlokoa ba ho lemoha le ho lekanya chefo ena esale pele ho etsa maano a nepahetseng a kalafo. Se boetse se bua ka tšebeliso ea mekhoa ea phekolo e kang tocilizumab bakeng sa CRS le corticosteroids bakeng sa ICANS, tse ipakile li sebetsa ho fokotsa liketso tsena tse ka behang bophelo kotsing.
Ho feta moo, tlaleho e hlahloba chefo ea nako e telele, ho kenyeletsoa le cytopenia e telele (phokotso ea palo ea lisele tsa mali) le litlamorao tse tobileng, tse seng tsa hlahala, tse hlokang tlhokomelo le taolo e tsoelang pele. Phuputso e totobatsa hore, leha phekolo ea CAR-T e na le bokhoni bo boholo, bafani ba tlhokomelo ea bophelo ba tlameha ho hlomelloa ho sebetsana le litla-morao tsa eona tse ikhethang le tse tebileng.
Ka liteko tse tsoelang pele tsa bongaka le boqapi, lefapha lena le ntse le tsoela pele ho nts'etsapele maano a betere a ho laola chefo ena, e leng se lumellang phekolo ea CAR-T ho sebelisoa ka mokhoa o sireletsehileng le ka katleho.