Temohisiso e Ncha mabapi le Mefuta e Menyenyane ea Liphatsa tsa Lefutso ea Batho ba Baholo ba B-ALL
La 15 Pherekhong 2025, Shanghai – Tlhahlobo ea morao tjena e hatisitsoeng koranteng Mali e fana ka tlhahlobo e tebileng ea mefuta e fapaneng ea liphatsa tsa lefutso tsa B-cell Acute Lymphoblastic Leukemia (B-ALL) ea batho ba baholo, e leng mofetše o sa tloaelehang le o mabifi o nang le tebello e mpe haholo ho batho ba baholo ha o bapisoa le bana. Lilemong tse mashome a mabeli tse fetileng, lipatlisiso tsa genomic li fumane mefuta e fetang 20 e fapaneng ea liphatsa tsa lefutso tsa B-ALL, e 'ngoe le e 'ngoe e nang le litlamorao tse ikhethang bakeng sa karabelo ea kalafo le tebello.
Leha mekhoa ea phekolo e ikamahanyang le kotsi ea liphatsa tsa lefutso e fetotse maano a kalafo ho bana ba B-ALL, sebaka sa liphatsa tsa lefutso sa batho ba baholo ba B-ALL se ntse se sa utloisisoe hantle. Tlhahlobo ena e totobatsa temohisiso ea bohlokoa mabapi le mefuta-futa ea liphatsa tsa lefutso ho bakuli ba baholo 'me e totobatsa tlhoko ea ho kenyelletsa tlhahlobo ea liphatsa tsa lefutso tlhahlobong ea kamehla ho nolofalletsa maano a kalafo a ikhethileng.
Liphihlelo tsa Bohlokoa:
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Philadelphia Chromosome-Positive (Ph+) B-ALL:
E emela mofuta o tloaelehileng haholo ho batho ba baholo, haholo-holo ho ba fetang lilemo tse 55, Ph+ B-ALL e tsoa ho gene ea BCR::ABL1 fusion. Ho latela nalane, ho kopanngoa ha li-inhibitors tsa tyrosine kinase (TKIs) le li-antibodies tse reretsoeng monoclonal, joalo ka blinatumomab, ho ntlafalitse haholo sekhahla sa ho pholoha. Bopaki bo hlahang bo senola ho se tšoane ho hoholo ha baeloji ka har'a Ph+ B-ALL, bo totobatsang bohlokoa ba matšoao a limolek'hule joalo ka IKZF1 bakeng sa karohano ea likotsi le moralo oa kalafo. -
Liphetoho tse tlase tsa Hypodiploidy le TP53:
Ho fokola ha di-diploidy, ho khetholloang ka palo ea li-chromosome ea 30-39, ho atile haholo ho batho ba baholo 'me ho amana le liphetho tse mpe. Lithuto tsa morao tjena li totobatsa karolo ea liphetoho tsa TP53, tseo hangata li amanang le hematopoiesis ea clonal, ho khanneng mofuta ona o kotsi haholo. Liphuputso li bontša hore liphetoho tsena ha li susumetse feela ho qala ha lefu empa li ka boela tsa thusa maano a kamora ho lokolloa. -
Litokiso tsa KMT2A:
Hangata ho bonoang ho batho ba baholo ba B-ALL, ho hlophisoa bocha ha KMT2A ho amahanngoa le liphello tse mpe. Mekhoa e mecha ea phekolo, joalo ka li-menin inhibitors, e na le tšepiso ea ho sebetsana le ho hanyetsa kalafo ha mofuta ona oa kalafo. -
Mefuta e sa Tloaelehang ea Meriana le Mekhoa ea Kalafo e Hlahang:
Mefuta e menyenyane e kang ho kopana ha TCF3::PBX1 le TCF3::HLF, le hoja ho sa tloaeleha, e bontsha mefuta e mengata ya baeloji le ya bongaka. Lintlha tse kgothalletsang pele ho tleliniki di bontsha kutlwisiso ho di-agent tse ntjha tse kang venetoclax le BET inhibitors, e bula tsela bakeng sa dikgetho tse ntjha tsa kalafo.
Litlamorao tsa Bongaka:
Tlhahlobo e hloka ho kenyelletsoa ha mekhoa e tsoetseng pele ea ho hlahloba liphatsa tsa lefutso, ho kenyeletsoa le tatellano ea mongolo o felletseng, ho khetholla mefuta e itseng ea liphatsa tsa lefutso tsa B-ALL ea batho ba baholo. Mokhoa ona o ka ntlafatsa karohano ea likotsi, oa tataisa liqeto tsa kalafo, le ho ntlafatsa tlhokomelo ea lefu le saletseng le lenyenyane (MRD).