Mokuli oa Australia o Finyella Karabelo e Hlollang ea Pele ka Phekolo ea BIOOCUS Medical Group ea Dual CD19/CD20 CAR-T bakeng sa DLBCL e Khutlileng
Rodney Charles Monger, monna ea lilemo li 68 ea tsoang Australia, o ile a fumanoa a e-na le lefu la ho ruruha ha letlalo le lenyenyane. Lymphoma ea Lisele tsa B (DLBCL) dilemo tse tharo tse fetileng. Ha a batla tlhokomelo e tswetseng pele, o ile a retelehela ho BIOOCUS Medical Group ka Phato 2025. Tlhahlobo ya lymph node ya molomo wa popelo e netefaditse hore lymphoma ya B-cell e hlaselang e simolohile bohareng ba dikokwana-hloko. Immunohistochemistry e ne e le ntle haholo bakeng sa CD20, CD19, le CD10, ka tlhahiso e phahameng ya Bcl-6, Bcl-2 (70%+), le c-MYC (60%+). Diteko tsa lefutso di senotse ho hlophiswa botjha ha BCL2 ke FISH le diphetoho diphatseng tsa lefutso tsa EZH2, KMT2D, TNFRSF14, NRAS, le TPMT—matshwao a hlakileng a boemo bo mabifi le bo kotsing e kgolo.
Kamora ho fumana pola e kopantsoeng le BTK inhibitor le lenalidomide, e lateloe ke chemotherapy ea FC lymphodepletion, lefu la Monghali Monger le ile la lula le sa sebetse hantle. Sehlopha sa BIOOCUS Medical Group se khothalelitse phekolo ea bona e ncha ea lisele tsa CD19/CD20 CAR-T tse nang le sepheo se habeli.
Ka la 8 Loetse 2025, Monghadi Monger o ile a fumana pheko ya disele tsa CD19/CD20 CAR-T tsa autologous. Ho makatsang ke hore ha a ka a ba le pheko ya cytokine release syndrome (CRS) le pheko ya immune effect cell-associated neurotoxicity syndrome (ICANS), e leng se ileng sa fella ka tsela e boreleli ya kamora pheko e ileng ya mo boloka a tsitsitse a bile a na le tshepo ho tloha letsatsing la pele.
Tlhokomelo ea mali a ka thoko e bontšitse katoloso e tsotehang ea lisele tsa CAR-T, e tiisang ho kenngoa le ho ata ho hoholo ha tsona. Letsatsing la 4 kamora ho kenngoa, lisele tsa CAR19+ e ne e le 0.50% ea lisele tsa CD3+ T (boleng bo felletseng 6.04 × 10⁷/L) le lisele tsa CAR20+ 0.41% (4.96 × 10⁷/L). Letsatsing la 7, CAR19+ e nyolohetse ho 1.68% (1.40 × 10⁷/L) le CAR20+ ho ea ho 1.63% (1.36 × 10⁷/L). Letsatsing la 10, CAR19+ e fihlile ho 31.43% ea lisele tsa CD3+ T (boleng bo felletseng 3.13 × 10⁸/L) le CAR20+ e fihlile ho 32.74% (boleng bo felletseng 3.26 × 10⁸/L). Potoloho ea phallo ea mali e boetse e bontšitse kabo e leka-lekaneng ho pholletsa le li-subset tsa CD4+ le CD8+ tse nang le tlhahiso e matla ea CAR e habeli, e bonts'ang bokhoni ba phekolo ea ho khothaletsa ho phehella ho matla ha 'mele le ho ata ha oona.
Nakong ea tlhahlobo ea morao-rao (letsatsi la 10), Monghali Monger o ntse a tsoela pele ho sebetsa hantle ka bongaka. O sebelisa meriana e nooang e etselitsoeng motho ka mong e kenyeletsang acyclovir, sulfamethoxazole e kopantsoeng, orelabrutinib, lenalidomide, le meriana e tšehetsang, ka ho beha leihlo khafetsa lipalo tsa mali, tšebetso ea sebete le liphio, le matšoao a ho ruruha.
Sehlopha sa BIOOCUS Medical Group se fane ka tšehetso e felletseng, e shebaneng le bakuli ho pholletsa le bophelo, ho kenyeletsoa le bolulo bo mabothobotho, lijo tse nang le phepo e nepahetseng, thuso ea lipalangoang le likeletso tsa kelello bakeng sa Monghali Monger le ba lelapa la hae. Mokhoa ona o akaretsang o ile oa mo lumella ho tsepamisa maikutlo ka botlalo ho foleng.
Nyeoe ea Monghali Monger e bontša bokhoni ba phetoho ba phekolo ea BIOOCUS Medical Group ea CD19/CD20 CAR-T bakeng sa bakuli ba nang le DLBCL e khutlelang morao/e sa sebetseng hantle. Katoloso e potlakileng le e matla ea lisele tsa CAR-T ntle le chefo e matla e totobatsa boemo bo botle ba polokeho ea sehlahisoa le ts'ebetso e matla ea ho loantša hlahala - esita le ho mokuli ea hōlileng ea nang le litšobotsi tse kotsi tsa limolek'hule.