Umurwayi wo muri Ositaraliya yakiriye neza cyane akoresheje uburyo bwa BIOOCUS Medical Group bwo kuvura indwara ya DLBCL yasubitse ku barwayi bayo.
Rodney Charles Monger, umugabo w'imyaka 68 ukomoka muri Ositaraliya, yasanzwemo indwara ya diffuse large Lymphoma y'uturemangingo twa B (DLBCL) imyaka itatu mbere yaho. Yashakaga ubuvuzi buhanitse, yiyambaje BIOOCUS Medical Group muri Kanama 2025. Isuzuma rya lymph node yo mu mura ryemeza ko lymphoma ya B-cell lymphoma ikomoka ku mibare y’uturemangingo. Immunohistochemistry yagaragaje neza ko CD20, CD19, na CD10 zagaragaye cyane, hamwe n’ubwiyongere bwa Bcl-6, Bcl-2 (70%+), na c-MYC (60%+). Isuzuma rya gene ryagaragaje ko BCL2 yasubiwemo na FISH na mutations muri EZH2, KMT2D, TNFRSF14, NRAS, na TPMT—ibimenyetso bigaragaza ko hari imiterere ikomeye kandi ishobora gutera ibyago byinshi.
Nyuma yo guhabwa pola ivanze n'umuti ugabanya ubukana bwa BTK na lenalidomide, hagakurikiraho imiti ya FC lymphodepletion chemotherapy, indwara ya Bwana Monger yakomeje kuba iyoroheje. Itsinda rya BIOOCUS Medical Group ryatanze inama ku buryo bushya bwo kuvura CD19/CD20 CAR-T cell cells mu buryo bubiri.
Ku ya 8 Nzeri 2025, Bwana Monger yahawe selile za CAR-T za autologous CD19/CD20. Igitangaje ni uko nta cytokine release syndrome (CRS) yigeze agira ndetse nta n'indwara y'ubudahangarwa bw'umubiri (ICANS), bituma agenda neza nyuma yo guhabwa selile, bituma agumana icyizere kuva ku munsi wa mbere.
Gukurikirana amaraso mu nkengero z'umuyoboro byagaragaje ko uturemangingo twa CAR-T twagutse cyane, byemeza ko twashyizwemo neza kandi turushaho kwiyongera. Ku munsi wa 4 nyuma yo guterwa, uturemangingo twa CAR19+ twari 0.50% by'uturemangingo twa CD3+ T (agaciro kabyo ni 6.04 × 10⁷/L) na CAR20+ twari 0.41% (4.96 × 10⁷/L). Ku munsi wa 7, CAR19+ yazamutse igera kuri 1.68% (1.40 × 10⁷/L) na CAR20+ igera kuri 1.63% (1.36 × 10⁷/L). Ku munsi wa 10, CAR19+ yageze kuri 31.43% by'uturemangingo twa CD3+ T (agaciro kabyo ni 3.13 × 10⁸/L) na CAR20+ igera kuri 32.74% (agaciro kabyo ni 3.26 × 10⁸/L). Isuzuma ry’uburyo amaraso akwirakwira mu mubiri ryagaragaje ko ubwiyongere bw’amaraso mu buryo buringaniye mu miterere ya CD4+ na CD8+ bufite imikorere ibiri ikomeye ya CAR, bigaragaza ubushobozi bw’ubu buvuzi bwo gutuma habaho gukomeza no kwiyongera kw’amaraso mu mubiri.
Mu ikurikiranwa rya nyuma (umunsi wa 10), Bwana Monger akomeje kumererwa neza mu buvuzi. Ari ku miti ikoreshwa mu kunyobwa ikubiyemo acyclovir, sulfamethoxazole, orelabrutinib, lenalidomide, n'imiti ifasha, akurikiranwa buri gihe mu maraso, imikorere y'umwijima n'impyiko, ndetse n'ibimenyetso by'ububyimbirwe.
Itsinda rya BIOOCUS Medical Group ryatanze ubufasha bwuzuye kandi bugamije abarwayi muri icyo gihe cyose, harimo icumbi ryiza, amafunguro afite intungamubiri, ubufasha mu gutwara abantu n'ibintu, ndetse n'ubujyanama mu by'imitekerereze ya Bwana Monger n'umuryango we. Ubu buryo buhuriweho bwamufashije kwibanda ku gukira byuzuye.
Urubanza rwa Bwana Monger rugaragaza ubushobozi bwo guhindura uburyo bwo kuvura bwa BIOOCUS Medical Group bwa CD19/CD20 CAR-T ku barwayi bafite DLBCL yongeye kurwara cyangwa idafite uburozi bukabije. Kwaguka vuba kandi gukomeye kw'uturemangingo twa CAR-T tudafite uburozi bukabije bigaragaza umutekano mwiza w'uyu muti n'imikorere ikomeye yo kurwanya ikibyimba - ndetse no ku murwayi ukuze ufite imiterere y'uturemangingo ishobora gutera ibyago byinshi.