Indwara ya Sickle Cell na Thalassemia

Muri BIOOCUS International Treatment Center, twishimiye kumenyekanisha Hemo-seli, uburyo bushya bwo kuvura ingirabuzima fatizo butanga icyizere gishya ku barwayi barwaye indwara y'uturemangingo tw'umusemburo (SCD) na thalassemia iterwa no guterwa amaraso (TDT)Hemo-selisi yagenewe gukemura impamvu nyamukuru y’izi ndwara, itanga ubuvuzi bushobora kuvura rimwe gusa.

Hemo-cel ni iki?

Hemo-cel ni uburyo bugezweho bwo kuvura bukoresha uturemangingo tw’amaraso n’uturemangingo tw’umurwayi (HSPCs), twahinduwe mu buryo bw’uturemangingo kugira ngo tubone hemoglobine nziza. Mu gukosora gene itera ikibazo cy’amaraso, Hemo-cel ishobora kunoza cyane ubuzima bw’abarwayi, ishobora gukuraho gukenera guterwa amaraso buri gihe no gutanga igisubizo cy’ubuzima bwabo bwose.

Hemo-cell ikora ite?

Uburyo bwo kuvura butangirana no gukusanya HSPCs mu maraso y'umurwayi. Izi selile zikongerwa hanze y'umubiri hakoreshejwe vector ya lentiviral izana gene ya β-globin yahinduwe. Iyo selile zimaze kwitegura, zisubizwa mu murwayi, aho zitangira gukora selile zitukura zifite ubuzima bwiza zishobora gukora hemoglobine ikora neza. Iyi gahunda igarura uburinganire hagati y'urunigi rwa α-globin na β-globin mu maraso, ikagabanya neza ibimenyetso by'amaraso make kandi igatuma umurwayi ashobora kugera ku ntego ze. kwigenga mu gutera amaraso.

Ibisubizo byagaragaye

Igeragezwa rya Hemo-cell mu buvuzi ryagaragaje intsinzi itangaje:

• 100% by'abarwayi mu igeragezwa yabashije gutera umwongo w'amagufwa neza.
• Abarwayi benshi babaye bidashingiye ku guterwa amaraso mu byumweru bike nyuma yo kuvurwa.
• Umurwayi umwe amaze hafi imyaka igera kuri ibiri adaterwa amaraso imyaka ine nta ngaruka zikomeye zigaragara.
• Ubu buvuzi bufasha kandi kugabanya ubucucike bwinshi mu byuma, ikibazo gikunze kugaragara ku barwayi ba TDT baterwa amaraso buri gihe.

Ubundi buryo butekanye kurushaho

Bitandukanye n'uburyo busanzwe bwo kuvura nko gutera utunyangingo tw'amaraso mu maraso (HSCT), bisaba umuntu utanga utwo tunyangingo kandi bikaba bifite ibyago nko kuba indwara ya graft-versus-host (GVHD), Hemo-cell ikoresha uturemangingo tw'umurwayi ubwe, kwirinda izi ngorane. Ibi bituma ubuvuzi umutekano kandi bikaba byoroshye ku barwayi benshi, hatabayeho ubuvuzi bw'igihe kirekire bugabanya ubudahangarwa bw'umubiri.

Kwaguka kwacu ku Isi

Nyuma yo kugera ku ntsinzi ikomeye mu Bushinwa, ubu turimo kwagura uburyo Hemo-cel iboneka ku isi hose. Hamwe n'ubufatanye mu buvuzi muri Arabiya Sawudite, Tayilande, Maleziya, n'ibindi byinshi, twiyemeje gutuma ubu buvuzi bushya bugera ku barwayi ku isi yose.

Ahazaza hatabayeho guterwa amaraso

Hemo-cell itanga ahazaza heza ku bantu barwaye SCD na beta-thalassemia. Tekereza ubuzima buzira guterwa amaraso buri gihe, bufite ubushobozi bwo gukira burundu. Muri BIOOCUS, twiyemeje gushyira iki cyerekezo mu bikorwa binyuze mu buryo bugezweho bwo kuvura imiterere y’uturemangingo nka Hemo-cell.

Twandikire uyu munsi kugira ngo umenye byinshi ku buryo Hemo-cell ishobora guhindura urugendo rwawe rwo kuvurwa no gutanga ejo hazaza heza kandi hafite ubuzima bwiza.